Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

Malaria Journal

Volumn 11, Issue , 2012, Pages

  White, Nicholas J ^a   Qiao, Li Guo ^b   Qi, Gao ^c   Luzzatto, Lucio ^d  

^a MAHIDOL UNIVERSITY   (Thailand)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^c JIANGSU INSTITUTE OF PARASITIC DISEASES   (China)

^d ISTITUTO TOSCANO TUMORI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; CHLOROQUINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEMOGLOBIN; PRIMAQUINE;

ABDOMINAL DISCOMFORT; ANOPHELES; ARTICLE; DISEASE SEVERITY; DISEASE TRANSMISSION; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; GAMETOCYTE; GENE LOCUS; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HEMOLYTIC ANEMIA; HUMAN; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM OVALE; PLASMODIUM OVALE MALARIA; PLASMODIUM VIVAX; PLASMODIUM VIVAX MALARIA; SINGLE DRUG DOSE;

ADULT; ANEMIA, HEMOLYTIC; ANIMALS; ANOPHELES; ANTIMALARIALS; ARTEMISININS; DRUG THERAPY, COMBINATION; FEMALE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HUMANS; INSECT VECTORS; MALARIA, FALCIPARUM; MALE; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIMAQUINE;

EID: 84870891528     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-418     Document Type: Article

References (53)

1. Glucose-6-phosphate dehydrogenase deficiency. Luzzatto L, Poggi V, Nathan & Oski's Hematology of Infancy and Chilhood Philadelphia: Saunders, Orkin S, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE, 2008 883 907 23316365
2. Glucose-6-phosphate dehydrogenase deficiency. Cappellini MD, Fiorelli G, Lancet 2008 371 64 74 10.1016/S0140-6736(08)60073-2 18177777
3. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. Howes RE, Piel FB, Patil AP, Nyangiri OA, Gething PW, Dewi M, Hogg MM, Battle KE, Padilla CD, Baird JK, Hay SI, PLoS Med 2012 9 1001339 10.1371/journal.pmed.1001339 23152723
4. World Health Organization, Guidelines for the Treatment of Malaria Geneva: World Health Organization 2010
5. World Health Organization Global Malaria programme, Global plan for artemisinin resistance containment (GPARC) Geneva: World Health Organization http://www.who.int/malaria/publications/atoz/artemisinin-resistance-containment- 2011.pdf (accessed Nov 1, 2012)
6. Effects of artemisinin derivatives on malaria transmissibility. Price RN, Nosten F, Luxemburger C, ter Kuile FO, Paiphun L, Chongsuphajaisiddhi T, White NJ, Lancet 1996 347 1654 1658 10.1016/S0140-6736(96)91488-9 8642959 (Pubitemid 26177386)
7. Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. Shekalaghe S, Drakeley C, Gosling R, Ndaro A, van Meegeren M, Enevold A, Alifrangis M, Mosha F, Sauerwein R, Bousema T, PLoS One 2007 2 1023 10.1371/journal.pone.0001023 17925871 (Pubitemid 351486737)
8. Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria. Pukrittayakamee S, Chotivanich K, Chantra A, Clemens R, Looareesuwan S, White NJ, Antimicrob Agents Chemother 2004 48 1329 1334 10.1128/AAC.48.4.1329-1334.2004 15047537 (Pubitemid 38405489)
9. Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes. Drakeley CJ, Jawara M, Targett GA, Walraven G, Obisike U, Coleman R, Pinder M, Sutherland CJ, Trop Med Int Health 2004 9 53 61 10.1046/j.1365-3156.2003.01169.x 14728607 (Pubitemid 38178012)
10. Transmission-blocking activities of quinine, primaquine, and artesunate. Chotivanich K, Sattabongkot J, Udomsangpetch R, Looareesuwan S, Day NP, Coleman RE, White NJ, Antimicrob Agents Chemother 2006 50 1927 1930 10.1128/AAC.01472-05 16723547 (Pubitemid 43807507)
11. A randomized open-label trial of artesunate-sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. El-Sayed B, El-Zaki SE, Babiker H, Gadalla N, Ageep T, Mansour F, Baraka O, Milligan P, Babiker A, PLoS One 2007 2 1311 10.1371/journal.pone.0001311 (Pubitemid 351802583)
12. Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. Okell LC, Drakeley CJ, Ghani AC, Bousema T, Sutherland CJ, Malar J 2008 7 125 10.1186/1475-2875-7-125
13. Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial. Smithuis F, Kyaw MK, Phe O, Win T, Aung PP, Oo AP, Naing AL, Nyo MY, Myint NZ, Imwong M, Ashley E, Lee SJ, White NJ, Lancet Infect Dis 2010 10 673 681 10.1016/S1473-3099(10)70187-0 20832366
14. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Bousema T, Drakeley C, Clin Microbiol Rev 2011 24 377 410 10.1128/CMR.00051-10 21482730
15. Primaquine to prevent transmission of falciparum malaria. White NJ, Lancet Infect Dis 2012 [Epub ahead of print]
16. Infectivity to mosquitoes of Plasmodium falciparum as related to gametocyte density and duration of infection. Jeffery GM, Eyles DE, Am J Trop Med Hyg 1955 4 781 789 13259002
17. Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum. Barnes KI, White NJ, Acta Trop 2005 94 230 240 10.1016/j.actatropica.2005.04.014 15878154 (Pubitemid 40720329)
18. Die behandlung der natuerlichen menschlichen malaria-infektionen mit Plasmochin. Mühlens P, Arch Schiffs Tropenhyg 1926 30 25 32
19. Die behandlung der natuerlichen menschlichen malaria-infektionen mit Plasmochin. Mühlens P, Fischer O, Arch Schiffs TropenHyg 1927 31 7 42
20. Malariatherpaie mit Plasmochin in Spanien. Roehl W, Arch Schiffs TropenHyg 1927 31 48 58
21. The viability of gametocytes in the blood of plasmochin-treated patients. Barber MA, Komp WHW, 16thAnn Rept Med Dept United Fruit Co 1927 60 62
22. The effect of small doses of plasmochin on the viability of gametocytes of malaria as measured by mosquito infection experiments. Barber MA, Komp WH, Newman BM, Pub Hlth Rep United Fruit Co 1929 44 1409 1420
23. L'azzione sterlizzante della plasmochina sui gametociti di parassiti malarigeni e sua importanza profilattica. Jerace F, Giovannola A, Riv Malariol 1933 12 457
24. Further observations on the effects of plasmochin and plasmochin-compound on the gametocytes of benign tertian and subtertian malaria. Manson-Bahr PH, Lancet 1928 214 25 26
25. Observations on the action of quinine, atebrin and plasmoquine on the gametocytes of Plasmodium falciparum. MacKerras MJ, Ercole QN, Trans R Soc Trop Med Hyg 1949 42 455 463 10.1016/0035-9203(49)90051-6 18118367
26. Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report. Edgecomb JH, Arnold J, Yount EH Jr, Alving AS, Eichelberger L, Jeffery GM, Eyles D, Young MD, J Natl Malar Soc 1950 9 285 292 14804087
27. The effect of small doses of primaquine upon malaria infections. Young MD, Ind J Malariol 1959 13 69 74
28. Li GQ, Chen PQ, Studies conducted in Xuan Loc Hospital, Dong Nai Province Cambodia: Vietnam, 1993-1996, and Kampong Speu Province Hospital 2003-2004
29. Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Stepniewska K, Price RN, Sutherland CJ, Drakeley CJ, von Seidlein L, Nosten F, White NJ, Malar J 2008 7 249 10.1186/1475-2875-7-249
30. Malaria: some considerations regarding parasite productivity. Rosenberg R, Trends Parasitol 2008 24 487 491 10.1016/j.pt.2008.07.009 18805735
31. Review: improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations. Myint HY, Berman J, Walker L, Pybus B, Melendez V, Baird JK, Ohrt C, AmJTrop Med Hyg 2011 85 1010 1014 10.4269/ajtmh.2011.11-0498
32. The hemolytic effects of primaquine and related compounds. Beutler E, Blood 1959 14 103 139 13618370
33. G6PD deficiency. Beutler E, Blood 1994 84 3613 3636 7949118 (Pubitemid 24362456)
34. Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug. Clyde DF, Bull World Health Organ 1981 59 391 395 6976846 (Pubitemid 11024762)
35. Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Plasmodium vivax by intermittent regimens of drug administration: a preliminary report. Alving AS, Johnson CF, Tarlov AR, Brewer GJ, Kellermeyer RW, Carson PE, Bull World Health Organ 1960 22 621 631 13793053
36. Hemolytic effect of therapeutic drugs. Clinical considerations of the primaquine-type hemolysis. Kellermeyer RW, Tarlov AR, Brewer GJ, Carson PE, Alving AS, JAMA 1962 180 388 394 10.1001/jama.1962.03050180034008a 14454972
37. The haemolytic effect of various regimens of primaquine with chloroquine in American Negroes with G6PD deficiency and the lack of an effect of various antimalarial suppressive agents on erythrocyte metabolism. Brewer GJ, Zarafonetis CJ, Bull World Health Organ 1967 36 303 308 4864652
38. Interactions among primaquine, malaria infection and other antimalarials in Thai subjects. Edwards G, McGrath CS, Ward SA, Supanaranond W, Pukrittayakamee S, Davis TM, White NJ, Br J Clin Pharmacol 1993 35 193 198 10.1111/j.1365-2125.1993.tb05685.x 8443039 (Pubitemid 23055323)
39. Recht J, Ashley EA, White NJ, A review of the safety of 8-aminoquinolines World Health Organization in press
40. Mass administration of an antimalarial drug combining 4-aminoquinoline and 8-aminoquinoline in Tanganyika. Clyde DF, Bull World Health Organ 1962 27 203 212 14021798
41. Widespread use of primaquine for control of Plasmodium vivax epidemics in a population with varying degrees of G6PD deficiency. Kondrashin AV, Baranova AM, Sergiev VP, Med Parazitol (Mosk) 2010 4 4 8
42. Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. Pamba A, Richardson ND, Carter N, Duparc S, Premji Z, Tiono AB, Luzzatto L, Blood 2012 120 4123 4133 10.1182/blood-2012-03-416032 22993389
43. Predictors of severe hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency following exposure to oxidant stresses. Al-Sweedan SA, Jdaitawi H, Khriesat WM, Khader YY, Al-Rimawi HS, Hematol Oncol Stem Cell Ther 2009 2 354 357 20118060
44. Acute intravascular haemolysis in Vanuatu following a single dose of primaquine in individuals with glucose-6-phosphate dehydrogenase deficiency. Reeve PA, Toaliu H, Kaneko A, Hall JJ, Ganczakowski M, J Trop Med Hyg 1992 95 349 351 1404560
45. The course of experimentally induced haemolytic anaemia in a primaquine sensitive Caucasian. Pannacciulli IM, Tizianello A, Ajmar F, Salvidio E, Blood 1965 25 92 90 14255977
46. Primaquine sensitivity in Caucasians: hemolytic reactions induced by primaquine in G-6-PD deficient subjects. George JN, Sears DA, McCurdy PR, Conrad ME, J Lab Clin Med 1967 70 80 93 6027097
47. Malaria Protecting against bad air. Luzzatto L, Notaro R, Science 2001 293 442 443 10.1126/science.1063292 11463901 (Pubitemid 32679060)
48. In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals. Shekalaghe SA, ter Braak R, Daou M, Kavishe R, van den Bijllaardt W, van den Bosch S, Koenderink JB, Luty AJ, Whitty CJ, Drakeley C, Sauerwein RW, Bousema T, Antimicrob Agents Chemother 2010 54 1762 1768 10.1128/AAC.01135-09 20194698
49. Artemisinin resistance in Plasmodium falciparum malaria. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegårdh N, Socheat D, White NJ, N Engl J Med 2009 361 455 467 10.1056/NEJMoa0808859 19641202
50. Emergence of artemisinin resistant malaria on the western border of Thailand. Phyo AP, Nkhoma S, Ashley E, Nair S, McGready R, Moo CL, Al-Saai S, Dondorp A, Lwin KM, Singhasivanon P, Day NPJ, White NJ, Anderson TJC, Nosten F, Lancet 2012 379 1960 1966 10.1016/S0140-6736(12)60484-X 22484134
51. World Health Organization Global Malaria Programme, Updated WHO policy recommendation (October 2012): single dose primaquine as a gametocytocide in Plasmodium falciparum malaria. http://www.who.int/malaria/diagnosis-treatment/ treatment/who-pq-policy-recommendation/en/ accessed 20 November 2012
52. Primaquine for reducing Plasmodium falciparum transmission. Graves PM, Gelband H, Garner P, Cochrane Database Syst Rev 2012 9 CD008152
53. White N.J., Artemisinin resistance - The clock is ticking, Lancet, 2010, 376, 2051-2052.