Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity

PLoS Medicine

Volumn 5, Issue 11, 2008, Pages 1617-1628

  Okell, Lucy C ^a   Drakeley, Chris J ^a   Bousema, Teun ^b   Whitty, Christopher J M ^a   Ghani, Azra C ^c  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; PYRIMETHAMINE SULFADIAZINE; ANTIINFECTIVE AGENT; ARTEMISININ DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DRUG EFFICACY; GAMETOCYTE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MATHEMATICAL MODEL; PARASITE TRANSMISSION; PARASITEMIA; PLASMODIUM FALCIPARUM; PROPHYLAXIS; TANZANIA; ANIMAL; DISEASE TRANSMISSION; DRUG COMBINATION; FEMALE; MALE; MIDDLE AGED; NEWBORN; PARASITOLOGY; PRESCHOOL CHILD; THEORETICAL MODEL;

ADOLESCENT; ADULT; ANIMALS; ANTI-INFECTIVE AGENTS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; MODELS, THEORETICAL; TANZANIA; YOUNG ADULT;

EID: 56749164561     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0050226     Document Type: Article

References (68)

1. Bosman A, Mendis KN (2007) A major transition in malaria treatment: the adoption and deployment of artemisinin-based combination therapies. Am J Trop Med Hyg 77: 193-197.
2. Bjorkman A, Bhattarai A (2005) Public health impact of drug resistant Plasmodium falciparum malaria. Acta Trop 94: 163-169.
3. Bousema JT, Schneider P, Gouagna LC, Drakeley CJ, Tostmann A, et al. (2006) Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum. J Infect Dis 193: 1151-1159.
4. Drakeley CJ, Jawara M, Targett GA, Walraven G, Obisike U, et al. (2004) Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes. Trop Med Int Health 9: 53-61.
5. Sutherland CJ, Ord R, Dunyo S, Jawara M, Drakeley CJ, et al. (2005) Reduction of malaria transmission to anopheles mosquitoes with a six-dose regimen of co-artemether. PLoS Med 2: e92. doi:10.1371/journal.pmed.0020092
6. Targett G, Drakeley C, Jawara M, von Seidlein L, Coleman R, et al. (2001) Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae. J Infect Dis 183: 1254-1259.
7. WHO (2006) RBM factsheet 9: Facts on ACTs. Available: http://www.rbm.who.int/cmc_upload/0/000/015/364/RBMInfosheet_9.htm. Accesed 21 October 2008.
8. Feachem R, Sabot O (2008) A new global malaria eradication strategy. Lancet 371: 1633-1635.
9. Carrara VI, Sirilak S, Thonglairuam J, Rojanawatsirivet C, Proux S, et al. (2006) Deployment of early diagnosis and mefloquine-artesunate treatment of falciparum malaria in Thailand: The Tak Malaria Initiative. PLoS Med 3: e183. doi:10.1371/journal.pmed.0030183
10. Price RN, Nosten F, Luxemburger C, ter Kuile FO, Paiphun L, et al. (1996) Effects of artemisinin derivatives on malaria transmissibility. Lancet 347: 1654-1658.
11. Van Nam N, de Vries PJ, Van Toi L, Nagelkerke N (2005) Malaria control in Vietnam: The Binh Thuan experience. Trop Med Int Health 10: 357-365.
12. Sochantha T, Hewitt S, Nguon C, Okell L, Alexander N, et al. (2006) Insecticide-treated bednets for the prevention of Plasmodium falciparum malaria in Cambodia: A cluster-randomized trial. Trop Med Int Health 11: 1166-1177.
13. Barnes KI, Durrheim DN, Little F, Jackson A, Mehta U, et al. (2005) Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa. PLoS Med 2: e330. doi: 10.1371/journal.pmed.0020330
14. Bhattarai A, Ali AS, Kachur SP, Martensson A, Abbas AK, et al. (2007) Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. PLoS Med 4: e309. doi: 10.1371/journal.pmed.0040309
15. Lusingu JP, Vestergaard LS, Mmbando BP, Drakeley CJ, Jones C, et al. (2004) Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania. Malar J 3: 26.
16. Smith T, Beck HP, Kitua A, Mwankusye S, Felger I, et al. (1999) Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity. Trans R Soc Trop Med Hyg 93: 15-20.
17. Tediosi F, Maire N, Smith T, Hutton G, Utzinger J, et al. (2006) An approach to model the costs and effects of case management of Plasmodium falciparum malaria in sub-Saharan Africa. Am J Trop Med Hyg 75: 90-103.
18. Yeung S, Van Damme W, Socheat D, White NJ, Mills A (2008) Cost of increasing access to artemisinin combination therapy: The Cambodian experience. Malar J 7: 84.
19. Gelb MH (2007) Drug discovery for malaria: A very challenging and timely endeavor. Curr Opin Chem Biol 11: 440-445.
20. Kumar N, Zheng H (1990) Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. Parasitol Res 76: 214-218.
21. Bukirwa H, Critchley J (2006) Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria. Cochrane Database Syst Rev: CD004966. doi:10.1002/14651858.CD004966. pub2
22. Drakeley CJ, Carneiro I, Reyburn H, Malima R, Lusingu JP, et al. (2005) Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern Tanzania. J Infect Dis 191: 1589-1598.
23. Bodker R, Akida J, Shayo D, Kisinza W, Msangeni HA, et al. (2003) Relationship between altitude and intensity of malaria transmission in the Usambara Mountains, Tanzania. J Med Entomol 40: 706-717.
24. Chandler CI, Drakeley CJ, Reyburn H, Carneiro I (2006) The effect of altitude on parasite density case definitions for malaria in northeastern Tanzania. Trop Med Int Health 11: 1178-1184.
25. Pearce RJ, Drakeley C, Chandramohan D, Mosha F, Roper C (2003) Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania. Antimicrob Agents Chemother 47: 1347-1354.
26. Watkins WM, Mberu EK, Winstanley PA, Plowe CV (1997) The efficacy of antifolate antimalarial combinations in Africa: A predictive model based on pharmacodynamic and pharmacokinetic analyses. Parasitol Today 13: 459-464.
27. Collins WE, Jeffery GM (2003) A retrospective examination of mosquito infection on humans infected with Plasmodium falciparum. Am J Trop Med Hyg 68: 366-371.
28. Aron JL, May RM (1982) The population dynamics of malaria. In: Anderson RA editor. The population dynamics of infectious diseases: theory and applications. London: Chapman and Hall. pp. 139-179.
29. Collins WE, Jeffery GM (1999) A retrospective examination of sporozoite-and trophozoite-induced infections with Plasmodium falciparum: Development of parasitologic and clinical immunity during primary infection. Am J Trop Med Hyg 61: 4-19.
30. Missinou MA, Kun JF, Lell B, Kremsner PG (2001) Change in Plasmodium falciparum genotype during successive malaria episodes in Gabonese children. Parasitol Res 87: 1020-1023.
31. Woolhouse ME, Dye C, Etard JF, Smith T, Charlwood JD, et al. (1997) Heterogeneities in the transmission of infectious agents: Implications for the design of control programs. Proc Natl Acad Sci U S A 94: 338-342.
32. Smith T, Maire N, Dietz K, Killeen GF, Vounatsou P, et al. (2006) Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria. Am J Trop Med Hyg 75: 11-18.
33. Baird JK, Owusu Agyei S, Utz GC, Koram K, Barcus MJ, et al. (2002) Seasonal malaria attack rates in infants and young children in northern Ghana. Am J Trop Med Hyg 66: 280-286.
34. Owusu-Agyei S, Koram KA, Baird JK, Utz GC, Binka FN, et al. (2001) Incidence of symptomatic and asymptomatic Plasmodium falciparum infection following curative therapy in adult residents of northern Ghana. Am J Trop Med Hyg 65: 197-203.
35. Sama W, Owusu-Agyei S, Felger I, Dietz K, Smith T (2006) Age and seasonal variation in the transition rates and detectability of Plasmodium falciparum malaria. Parasitology 132: 13-21.
36. Bonnet S, Gouagna LC, Paul RE, Safeukui I, Meunier JY, et al. (2003) Estimation of malaria transmission from humans to mosquitoes in two neighbouring villages in south Cameroon: Evaluation and comparison of several indices. Trans R Soc Trop Med Hyg 97: 53-59.
37. Githeko AK, Brandling-Bennett AD, Beier M, Atieli F, Owaga M, et al. (1992) The reservoir of Plasmodium falciparum malaria in a holoendemic area of western Kenya. Trans R Soc Trop Med Hyg 86: 355-358.
38. Struik SS, Riley EM (2004) Does malaria suffer from lack of memory? Immunol Rev 201: 268-290.
39. Olliaro P, Pinoges L, Checchi F, Vaillant M, Guthmann JP (2008) Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment. Trop Med Int Health 13: 83-90.
40. Okell L, Drakeley C, Ghani AC, Bousema JT, Sutherland C (2008) Reduction of transmission from malaria patients by artemisinin combination therapies: A pooled analysis of six randomized trials. Malar J 7: 125.
41. Hay SI, Rogers DJ, Toomer JF, Snow RW (2000) Annual Plasmodium falciparum entomological inoculation rates (EIR) across Africa: Literature survey, Internet access and review. Trans R Soc Trop Med Hyg 94: 113-127.
42. White NJ, Pongtavornpinyo W (2003) The de novo selection of drug-resistant malaria parasites. Proc Biol Sci 270: 545-554.
43. Lengeler C (2004) Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Syst Rev: CD000363. doi:10.1002/14651858. CD000363.pub2
44. Smith DL, Dushoff J, Snow RW, Hay SI (2005) The entomological inoculation rate and Plasmodium falciparum infection in African children. Nature 438: 492-495.
45. Gosling RD, Drakeley CJ, Mwita A, Chandramohan D (2008) Presumptive treatment of fever cases as malaria: help or hindrance for malaria control? Malar J 7: 132.
46. Yeung S, White NJ (2005) How do patients use antimalarial drugs? A review of the evidence. Trop Med Int Health 10: 121-138.
47. WHO (2006) WHO guidelines for treatment of malaria. Geneva: WHO. Available: http://www.who.int/malaria/docs/TreatmentGuidelines2006.pdf. Accessed 21 October 2008.
48. White NJ (2008) How antimalarial drug resistance affects post-treatment prophylaxis. Malar J 7: 9.
49. Hastings IM, Watkins WM, White NJ (2002) The evolution of drug-resistant malaria: The role of drug elimination half-life. Philos Trans R Soc Lond B Biol Sci 357: 505-519.
50. Chen PQ, Li GQ, Guo XB, He KR, Fu YX, et al. (1994) The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinin. Chinese Med J 107: 709-711.
51. El-Sayed B, El-Zaki SE, Babiker H, Gadalla N, Ageep T, et al. (2007) A randomized open-label trial of artesunate-sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. PLoS ONE 2: e1311 doi:10.1371/journal.pone.0001311
52. Gardella F, Assi S, Simon F, Bogreau H, Eggelte T, et al. (2008) Antimalarial drug use in general populations of tropical Africa. Malar J 7: 124.
53. McCombie SC (2002) Self-treatment for malaria: the evidence and methodological issues. Health Policy Plan 17: 333-344.
54. National Bureau of Statistics of the United Republic of Tanzania (2003) Tanzania 2002 population and housing census.
55. Schellenberg D, Menendez C, Aponte J, Guinovart C, Mshinda H, et al. (2004) The changing epidemiology of malaria in Ifakara Town, southern Tanzania. Trop Med Int Health 9: 68-76.
56. Okiro EA, Hay SI, Gikandi PW, Sharif SK, Noor AM, et al. (2007) The decline in paediatric malaria admissions on the coast of Kenya. Malar J 6: 151.
57. [No authors listed] (2007) Is malaria eradication possible? Lancet 370: 1459.
58. Falk N, Maire N, Sama W, Owusu-Agyei S, Smith T, et al. (2006) Comparison of PCR-rflp and genescan-based genotyping for analyzing infection dynamics of Plasmodium falciparum. Am J Trop Med Hyg 74: 944-950.
59. Sama W, Dietz K, Smith T (2006) Distribution of survival times of deliberate Plasmodium falciparum infections in tertiary syphilis patients. Trans R Soc Trop Med Hyg 100: 811-816.
60. Eyles DE, Young MD (1951) The duration of untreated or inadequately treated Plasmodium falciparum infections in the human host. J Natl Malar Soc 10: 327-336.
61. Smith T, Charlwood JD, Takken W, Tanner M, Spiegelhalter DJ (1995) Mapping the densities of malaria vectors within a single village. Acta Trop 59: 1-18.
62. Miller MJ (1958) Observations on the natural history of malaria in the semi-resistant West African. Trans R Soc Trop Med Hyg 52: 152-168.
63. Bruce-Chwatt LJ (1963) A longitudinal survey of natural malaria infection in a group of West African adults. I. West Afr Med J 12: 141-173.
64. Jeffery GM, Eyles DE (1954) The duration in the human host of infections with a Panama strain of Plasmodium falciparum. Am J Trop Med Hyg 3: 219-224.
65. Ruebush TK, Kern MK, Campbell CC, Oloo AJ (1995) Self-treatment of malaria in a rural area of western Kenya. Bull World Health Organ 73: 229-236.
66. Espino F, Manderson L (2000) Treatment seeking for malaria in Morong, Bataan, the Philippines. Soc Sci Med 50: 1309-1316.
67. Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L, et al. (2008) Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand. Antimicrob Agents Chemother 52: 1052-1061.
68. Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ (2000) Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Antimicrob Agents Chemother 44: 697-704.