Managing malaria in the intensive care unit

British Journal of Anaesthesia

Volumn 113, Issue 6, 2014, Pages 910-921

  Marks, M ^a,b   Gupta Wright, A ^a,b   Doherty, J F ^a   Singer, M ^c   Walker, D ^c  

^a HOSPITAL FOR TROPICAL DISEASES   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

ARDS; ICU; Imported infections; Malaria

Indexed keywords

ANTIMALARIAL AGENT;

ACUTE KIDNEY FAILURE; ANEMIA; ANTIMALARIAL DRUG RESISTANCE; BLOOD CLOTTING DISORDER; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; EXCHANGE BLOOD TRANSFUSION; HEART FUNCTION; HUMAN; HYPOGLYCEMIA; INTENSIVE CARE UNIT; MALARIA; META ANALYSIS (TOPIC); MIXED INFECTION; NEUROLOGIC DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT INFECTION; REVIEW; RISK; STRATIFICATION; ALGORITHM; COMPLICATION; FLUID THERAPY; INTENSIVE CARE; MALARIA, FALCIPARUM; PROCEDURES; TRAVEL;

ALGORITHMS; ANTIMALARIALS; CRITICAL CARE; DIAGNOSIS, DIFFERENTIAL; EXCHANGE TRANSFUSION, WHOLE BLOOD; FLUID THERAPY; HUMANS; INTENSIVE CARE UNITS; MALARIA; MALARIA, FALCIPARUM; PROGNOSIS; TRAVEL;

EID: 84964312560     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu157     Document Type: Review

References (106)

1. United Nations World Tourism Organization (UNWTO). UNWTO Tourism Highlights, 2012 Edn. Madrid, Spain UNWTO, 2012
2. World Health Organization. World Malaria Report 2012. WHO. Geneva, 2012
3. Mali S, Kachur SP, Arguin PM. Malaria surveillance-United States, 2009. MMWR Surveill Summ 2012; 61: 1
4. OdoliniS, ParolaP, Gkrania-KlotsasE, et al. Travel-related imported infections in Europe, EuroTravNet 2009. Clin Microbiol Infect 2012; 18: 468-74
5. Leder K, Torresi J, Libman MD, et al. GeoSentinel surveillance of illness in returned travelers, 2007-2011. Ann Intern Med 2013; 158: 456-68
6. Baird JK Severe and fatal vivax malaria challenges 'benign tertian malaria' dogma. Ann Trop Paediatr 2009; 29: 251-2
7. Cox-Singh J, Hiu J, Lucas SB, et al. Severe malaria-a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. Malar J 2010; 9: 10
8. Checkley AM, Smith A, Smith V, et al. Risk factors for mortality from imported falciparumm alaria in the United Kingdom over 20 years: an observational study. Br Med J 2012; 344: e2116
9. European Centre for Disease Prevention and Control. Annual Epidemiological Report 2012: Reporting on 2010 Surveillance Data and 2011 Epidemic Intelligence Data. Stockholm. Available from http://www.ecdc.europa.eu/en/publications/-layouts/forms/Publication-DispForm.aspx?List=4f55ad51-4aed-4d32-b960-af70113dbb90&ID=753&RootFolder=%2Fen%2Fpublications%2FPublications&Web=270275b7-419a-4352-a8fb-f0c757d92e66
10. González A, Nicolás JM, Muñoz J, et al. Severe imported malaria in adults: retrospective study of 20 cases. Am J Trop Med Hyg 2009; 81: 595-9
11. Marks ME, Armstrong M, Suvari MM, et al. Severe imported falciparum malaria among adults requiring intensive care: a retrospective study at the hospital for tropical diseases, London. BMC Infect Dis 2013; 13: 118
12. Santos LC, Abreu CF, Xerinda SM, Tavares M, Lucas R, Sarmento AC. Severe imported malaria in an intensive care unit: a review of 59 cases. Malar J 2012; 11: 96
13. Smith AD, Bradley DJ, Smith V, et al. Imported malaria and high risk groups: observational study using UK surveillance data 1987-2006. Br Med J 2008; 337: a120-a120
14. Phillips A, Bassett P, Zeki S, Newman S, Pasvol G. Risk factors for severe disease in adults with falciparum malaria. Clin Infect Dis 2009; 48: 871-8
15. Ericsson CD, Hatz C, Leder K, et al. Illnessintravelers visiting friends and relatives: a review of the GeoSentinel surveillance network. Clin Infect Dis 2006; 43: 1185-93
16. Kain KC, Harrington MA, Tennyson S, Keystone JS. Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 1998; 27: 142-9
17. Warrell D, Gilles H. Essential Malariology, 4th Edn. London: Hodder Arnold, 2002
18. Daneshvar C, Davis TME, Cox-Singh J, et al. Clinical and laboratory features of human Plasmodium knowlesi infection. Clin Infect Dis 2009; 49: 852-60
19. Roberts C, Armstrong M, Zatyka E. Gametocyte carriage in Plasmodium falciparum-infected travellers. Malar J 2013; 12: 31
20. Bruneel F, Tubach F, Corne P, et al. Severe imported falciparum malaria: a cohort study in 400 critically ill adults. PLoS ONE 2010; 5: e13236
21. Flick K, Chen Q. var genes, PfEMP1 and the human host. Mol Biochem Parasit 2004; 134: 3-9
22. Berendt AR, Simmons DL, Tansey J, Newbold CI, Marsh K. Intercellular adhesion molecule-1isan endothelial cell adhesion receptor for Plasmodium falciparum. Nature 1989; 341: 57-9
23. Hanson JP, Lam SWK, MohantyS, et al. Fluid resuscitation ofadults with severe falciparum malaria: effects on acid-base status, renal function, and extravascular lung water. Crit Care Med 2013; 41: 972-81
24. Dondorp AM, Desakorn V, Pongtavornpinyo W, et al. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med 2005; 2: e204
25. Health Protection Agency. Malaria-Algorithm for Initial Assessment and Management in Adults. Available from http://www.hpa.org.uk/webc/HPAwebFile/HPAweb-C/1240212774627 (accessed September 2013)
26. Lalloo DG, Shingadia D, Pasvol G, et al. UK malaria treatment guidelines. J Infect 2007; 54: 111-21
27. World Health Organization. Guidelines for the Treatment of Malaria, 2nd Edn. Geneva, 2011
28. Payne D. Use and limitations of light microscopy for diagnosing malaria at the primary health care level. Bull World Health Organ 1988; 66: 621-6
29. World Health Organization. Severe falciparum malaria. Trans R Soc Trop Med Hyg 2000; 94(Suppl.): 1-90
30. Bruneel F, Hocqueloux L, Alberti C, et al. The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults. Am J Respir Crit Care Med 2003; 167: 684-9
31. Johnston V, Stockley JM, Dockrell D, et al. Fever in returned travellers presenting in the United Kingdom: recommendations for investigation and initial management. J Infection 2009; 59: 1-18
32. Dondorp A, Nosten F, Stepniewska K, Day N, White N. South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group. Lancet 2005; 366: 717-25
33. Dondorp AM, Fanello CI, Hendriksen ICE, et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010; 376: 1647-57
34. DTB. Artemisinins in malaria treatment in the UK. Drug Ther Bull 2010; 48: 129-32
35. Lin JT, Juliano JJ, Wongsrichanalai C. Drug-resistant malaria: the era of ACT. Curr Infect Dis Rep 2010; 12: 165-73
36. Amaratunga C, Sreng S, Suon S, et al. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect Dis 2012; 12: 851-8
37. Phyo AP, Nkhoma S, Stepniewska K, et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 2012; 379: 1960-6
38. Dondorp AM, Nosten F, Yi P, et al. Artemisinin resistance in Plasmodium falciparum malaria. New Engl J Med 2009; 361: 455-67
39. Van Genderen PJ, Hesselink DA, Bezemer JM, Wismans PJ, Overbosch D. Efficacy and safety of exchange transfusion as an adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a10-year single-center experience with a standardized treatment protocol. Transfusion 2010; 50: 787-94
40. Tan KR, Wiegand RE, Arguin PM. Exchange transfusion for severe malaria: evidence base and literature review. Clin Infect Dis 2013; 57: 923-8
41. Riddle MS, Jackson JL, Sanders JW, Blazes DL. Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis. Clin Infect Dis 2002; 34: 1192-8
42. Wiedemann HP, Wheeler AP, Bernard GR, et al. Comparison of two fluid-management strategies in acute lung injury. New Engl J Med 2006; 354: 2564-75
43. Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. New Engl J Med 2011; 364: 2483-95
44. Maitland K, George EC, Evans JA, et al. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med 2013; 11: 68
45. Ehrhardt S, Wichmann D, Hemmer CJ, Burchard GD, Brattig NW. Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria. Trop Med Int Health 2004; 9: 1099-103
46. Herr J, Mehrfar P, Schmiedel S, et al. Reduced cardiac output in imported Plasmodium falciparum malaria. Malar J 2011; 10: 160
47. Janka JJ, Koita OA, Traore B, et al. Increased pulmonary pressures and myocardial wall stressinchildren with severe malaria. JInfect Dis 2010; 202: 791-800
48. Nguyen HP, Hanson J, Bethell D, et al. A retrospective analysis of the haemodynamic and metabolic effects of fluid resuscitation in Vietnamese adults with severe falciparum malaria. PLoS ONE 2011; 6: e25523
49. Boyd JH, Forbes J, Nakada T, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 2011; 39: 259-65
50. Anstey NM, Jacups SP, Cain T, et al. Pulmonary manifestations of uncomplicated falciparum and vivax malaria: cough, small airways obstruction, impaired gas transfer, and increased pulmonary phagocytic activity. J Infect Dis 2002; 185: 1326-34
51. Ferguson ND, Fan E, Camporota L, et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 2012; 38: 1573-82
52. Taylor WRJ, Hanson J, Turner GDH, White NJ, Dondorp AM. Respiratory manifestations of malaria. Chest 2012; 142: 492-505
53. Badiaga S, Brouqui P, Carpentier JP, et al. Severe imported malaria: clinical presentationatthetimeofhospitaladmissionandoutcome in 42 cases diagnosed from 1996 to 2002. J Emerg Med 2005; 29: 375-82
54. Sahu S, Mohanty NK, Rath J, Patnaik SB. Spectrum of malaria complications in an intensive care unit. Singapore Med J 2010; 51: 226-9
55. Marsh K, Forster D, Waruiru C, et al. Indicators of life-threatening malaria in African children. New Engl J Med 1995; 332: 1399-404
56. Robinson T, Mosha F, Grainge M, Madeley R. Indicators of mortality in African adults with malaria. T Roy Soc Trop Med H 2006; 100: 719-24
57. Day NP, Hien TT, Schollaardt T, et al. The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria. J Infect Dis 1999; 180: 1288-97
58. Mohan A, Sharma SK, Bollineni S. Acute lung injury and acute respiratory distress syndrome in malaria. J Vect Borne Dis 2008; 45: 179-93
59. Briel M, Meade M, Mercat A, et al. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. J Am Med Assoc 2010; 303: 865-73
60. Lamontagne F, Briel M, Guyatt GH, Cook DJ, Bhatnagar N, Meade M. Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials. J Crit Care 2010; 25: 420-35
61. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009; 151: 566-76
62. Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39: 165-228
63. Ponsford MJ, Medana IM, Prapansilp P, et al. Sequestration and microvascular congestion are associated with coma in human cerebral malaria. J Infect Dis 2012; 205: 663-71
64. Vandroux D, Leaute B, Hoarau N, et al. High frequency oscillation ventilation and extracorporeal membrane oxygenation during pernicious malaria. Med Mal Infect 2011; 41: 209-12
65. Willcox ML, Forster M, Dicko MI, Graz B, Mayon-White R, Barennes H. Blood glucose and prognosis in children with presumed severe malaria: is there a threshold for 'hypoglycaemia'? Trop Med Int Health 2010; 15: 232-40
66. Jallow M, Casals-Pascual C, Ackerman H, et al. Clinical features of severe malaria associated with death: a 13-year observational study in the Gambia. PLoS ONE 2012; 7: e45645
67. Taylor TE, Molyneux ME, Wirima JJ, Fletcher KA, Morris K. Blood glucose levels in Malawian children before and during the administration of intravenous quinine for severe falciparum malaria. New Engl J Med 1988; 319: 1040-7
68. Sinclair D, Donegan S, Isba R, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev 2012; 6: CD005967
69. Martindale RG, McClave SA, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive Summary. Crit Care Med 2009; 37: 1757-61
70. Maude RJ, Hoque G, Hasan MU, et al. Timing of enteral feeding in cerebral malaria in resource-poor settings: a randomized trial. PLoS ONE; 2011; 6: e27273
71. Jaffar S, Van Hensbroek MB, Palmer A, Schneider G, Greenwood B. Predictors of a fatal outcome following childhood cerebral malaria. Am J Trop Med Hyg 1997; 57: 20-4
72. Hunt NH, Golenser J, Chan-Ling T, et al. Immunopathogenesis of cerebral malaria. Int J Parasitol 2006; 36: 569-82
73. Crawley J, Smith S, Muthinji P, Marsh K, Kirkham F. Electroencephalographic and clinical features of cerebral malaria. Arch Dis Child 2001; 84: 247-53
74. Crawley J, Waruiru C, Mithwani S, et al. Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. Lancet 2000; 355: 701-6
75. Kochar D, Kumawat B, Bajya H, Chauhan S, Kochar S, Agarwal R. Prophylactic role of single dose phenobarbitone in preventing convulsions in cerebral malaria. J Assoc Physicians India 1997; 45: 123-4
76. White NJ, Looareesuwan S, Phillips RE, Chanthavanich P, Warrell DA. Single dose phenobarbitone prevents convulsions in cerebral malaria. Lancet 1988; 2: 64-6
77. Meremikwu M, Marson AG. Routine anticonvulsants for treating cerebral malaria. Cochrane Database Syst Rev 2002; (2) CD002152
78. Warrell DA, Looareesuwan S, Warrell MJ, et al. Dexamethasone proves deleterious in cerebral malaria. A double-blind trial in 100 comatose patients. New Engl J Med 1982; 306: 313-9
79. Roberts I, Yates D, Sandercock P, et al. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebocontrolled trial. Lancet 2004; 364: 1321-8
80. Mohanty S, Mishra SK, Patnaik R, et al. Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial. Clin Infect Dis 2011; 53: 349-55
81. Charunwatthana P, Faiz MA, Ruangveerayut R, et al. Nacetylcysteine as adjunctive treatment in severe malaria: A randomized, double-blinded placebo-controlled clinical trial. Crit Care Med 2009; 37: 516-22
82. Hemmer CJ, Kern P, Holst FG, Nawroth PP, Dietrich M. Neither heparin nor acetylsalicylic acid influence the clinical course in human Plasmodium falciparum malaria: a prospective randomized study. Am J Trop Med Hyg 1991; 45: 608-12
83. Gordeuk V, Thuma P, Brittenham G, et al. Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. New Engl J Med 1992; 327: 1473-7
84. Van Hensbroek MB, Palmer A, Onyiorah E, et al. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis 1996; 174: 1091-7
85. Looareesuwan S, Wilairatana P, Vannaphan S, et al. Pentoxifylline as an ancillary treatment for severe falciparum malaria in Thailand. Am J Trop Med Hyg 1998; 58: 348-53
86. Das BS Renal failure in malaria. J Vect Bor Dis 2008; 45: 83-97
87. Prakash J, Singh AK, Kumar NS, Saxena RK. Acute renal failure in Plasmodium vivax malaria. J Assoc Physicians India 2003; 51: 265-7
88. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2012; 2: 19-36
89. Barsoum RS Malarial acute renal failure. J Am Soc Nephrol 2000; 11: 2147-54
90. Eiam-Ong S. Malarial nephropathy. Semin Nephrol 2003; 23: 21-33
91. Mishra SK, Das BS. Malaria and acute kidney injury. Semin Nephrol 2008; 28: 395-408
92. MacPherson GG, Warrell MJ, White NJ, Looareesuwan S, Warrell DA. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol 1985; 119: 385-401
93. Nguansangiam S, Day NPJ, Hien TT, et al. A quantitative ultrastructural study of renal pathology in fatal Plasmodium falciparum malaria. Trop Med Int Health 2007; 12: 1037-50
94. Day NP, Phu NH, Mai NT, et al. Effects of dopamine and epinephrine infusions on renal hemodynamics in severe malaria and severe sepsis. Crit Care Med 2000; 28: 1353-62
95. Nadjm B, Amos B, Mtove G, et al. WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study. Br Med J 2010; 340: c1350
96. Berkley J, Mwarumba S, Bramham K, Lowe B, Marsh K. Bacteraemia complicating severe malaria in children. T Roy Soc Trop Med H 1999; 93: 283-6
97. Scott JAG, Berkley JA, Mwangi I, et al. Relation between falciparum malaria and bacteraemia in Kenyan children: apopulation-based, case-control study and a longitudinal study. Lancet 2011; 378: 1316-23
98. Cunnington AJ, de Souza JB, Walther R-M, Riley EM. Malaria impairs resistance to Salmonella through heme- and heme oxygenase dependent dysfunctional granulocyte mobilization. Nat Med 2011; 18: 120-7
99. Haldar K, Mohandas N. Malaria, erythrocytic infection. andanemia. Hematology Am Soc Hematol Educ Program 2009; 1: 87-93
100. Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion requirements in critical care investigators, Canadian Critical Care Trials Group. New Engl J Med 1999; 340: 409-17
101. Carson JL, Terrin ML, Noveck H, et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. New Engl J Med 2011; 365: 2453-62
102. Thierfelder C, Schill C, Hatz C. Nüesch R. Trends in importedmalaria to Basel, Switzerland. J Travel Med 2008; 15: 432-6
103. Schwake L, Streit JP, Edler L, Encke J, Stremmel W, Junghanss T. Early treatment of imported falciparum malaria in the intermediate and intensive care unit setting: an 8-year single-center retrospective study. Crit Care 2008; 12: R22
104. Blumberg L, Lee RP, Lipman J, Beards S. Predictors of mortality in severe malaria: a two year experience in a non-endemic area. Anaesthesia Intensive Care 1996; 24: 217-23
105. Hanson J, Lee SJ, Mohanty S, et al. A simple score to predict the outcome of severe malaria in adults. Clin Infect Dis 2010; 50: 679-85
106. Mishra SK, Panigrahi P, Mishra R, Mohanty S. Prediction of outcome in adults with severe falciparum malaria: a new scoring system. Malar J 2007; 6: 24