LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses

Lipids in Health and Disease

Volumn 13, Issue 1, 2014, Pages

  Wang, Shao Hua ^a   Huang, Yan ^b   Yuan, Yang ^a   Xia, Wen Qing ^a   Wang, Pin ^a   Huang, Rong ^a  

^a AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

^b Department of Endocrinology   (China)

Author keywords

Apoptosis; Cognition; LDL receptor knock out; Synapse

Indexed keywords

BIOLOGICAL MARKER; CASPASE 3; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; SYNAPTOPHYSIN; APOPTOSIS REGULATORY PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; ENZYME ACTIVATION; HIPPOCAMPAL CA1 REGION; LIPID ANALYSIS; MALE; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PRESYNAPTIC POTENTIAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SPATIAL MEMORY; SYNAPSE; TRANSMISSION ELECTRON MICROSCOPY; WEIGHT GAIN; ANIMAL; C57BL MOUSE; COGNITION; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; MAZE TEST; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CA1 REGION, HIPPOCAMPAL; COGNITION; COGNITION DISORDERS; GENE EXPRESSION; MALE; MAZE LEARNING; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LDL; SYNAPSES;

EID: 84964312420     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-13-175     Document Type: Article

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