LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus

Neuroscience Research

Volumn 59, Issue 3, 2007, Pages 251-256

  Mulder, Monique ^a   Koopmans, Guido ^a   Wassink, Guido ^a   Mansouri, Ghais Al ^a   Simard, Marie Lune ^a   Havekes, Louis M ^b,c   Prickaerts, Jos ^a   Blokland, Arjan ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apolipoprotein E; Cholesterol; Low density lipoprotein receptor; Memory; Neurogenesis; Synaptic density

Indexed keywords

APOLIPOPROTEIN E; BROXURIDINE; CHOLESTEROL; IODINE 125; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; SYNAPTOPHYSIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA CELL; CELL PROLIFERATION; CHOLESTEROL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; MEMORY; MOUSE; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROBLASTOMA CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPATIAL MEMORY; SYNAPTOGENESIS; WILD TYPE;

ANIMALS; BIOLOGICAL MARKERS; BROMODEOXYURIDINE; CELL COUNT; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLESTEROL; DENTATE GYRUS; DOWN-REGULATION; HIPPOCAMPUS; HUMANS; MALE; MICE; MICE, KNOCKOUT; NEURAL PATHWAYS; NEURONAL PLASTICITY; PRESYNAPTIC TERMINALS; RECEPTORS, LDL; SYNAPTOPHYSIN;

EID: 34848857653     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2007.07.004     Document Type: Article

References (52)

1. Abdulkarim Y., and Hameed Z. Is the LDL receptor involved in cortical amyloid protein clearance?. Neurochem. Res. 31 6 (2006) 839-847
2. Algoed L., Caemaert J., et al. A large intracranial xanthoma in familial hypercholesterolemia. Clin. Neurol. Neurosurg. 96 1 (1994) 79-82
3. Beffert U., Danik M., et al. The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease. Brain Res. Brain Res. Rev. 27 2 (1998) 119-142
4. Bjorkhem I., and Meaney S. Brain cholesterol: long secret life behind a barrier. Arterioscler. Thromb. Vasc. Biol. 24 5 (2004) 806-815
5. Blain J.F., Paradis E., et al. A role for lipoprotein lipase during synaptic remodeling in the adult mouse brain. Neurobiol. Dis. 15 3 (2004) 510-519
6. Brown M.S., and Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 232 4746 (1986) 34-47
7. Cao D., Fukuchi K., et al. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiol. Aging 27 11 (2006) 1632-1643
8. Chen J., Zhang Z.G., et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann. Neurol. 53 6 (2003) 743-751
9. Cruz J.C., Sugii S., et al. Role of Niemann-Pick type C1 protein in intracellular trafficking of low-density lipoprotein-derived cholesterol. J. Biol. Chem. 275 6 (2000) 4013-4021
10. Cuthbert J.A., and Lipsky P.E. Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes. J. Lipid Res. 31 11 (1990) 2067-2078
11. Dehouck B., Fenart L., et al. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138 4 (1997) 877-889
12. Dietschy J.M., and Turley S.D. Thematic review series: brain lipids cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45 8 (2004) 1375-1397
13. Elias E.R., and Irons M. Abnormal cholesterol metabolism in Smith-Lemli-Opitz syndrome. Curr. Opin. Pediatr. 7 6 (1995) 710-714
14. Emsley J.G., Mitchell B.D., et al. Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells. Prog. Neurobiol. 75 5 (2005) 321-341
15. Francis G.A., Johnson R.L., et al. Cerebral cholesterol granuloma in homozygous familial hypercholesterolemia. CMAJ 172 4 (2005) 495-497
16. Gherardi E., Thomas K., et al. Growth requirements and expression of LDL receptor and HMG-CoA reductase in Hep G2 hepatoblastoma cells cultured in a chemically defined medium. J. Cell Sci. 103 Pt 2 (1992) 531-539
17. Hayashi H., Campenot R.B., et al. Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures. J. Biol. Chem. 279 14 (2004) 14009-14015
18. Hoglund K., Wallin A., et al. Effect of statins on beta-amyloid metabolism in humans: potential importance for the development of senile plaques in Alzheimer's disease. Acta Neurol. Scand. Suppl. 185 (2006) 87-92
19. Igbavboa U., Avdulov N.A., et al. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J. Neurochem. 69 4 (1997) 1661-1667
20. Ignatius M.J., Gebicke-Haerter P.J., et al. Apolipoprotein E in nerve injury and repair. Prog. Brain Res. 71 (1987) 177-184
21. Innerarity T.L., and Mahley R.W. Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins. Biochemistry 17 8 (1978) 1440-1447
22. Ishibashi S., Brown M.S., et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92 2 (1993) 883-893
23. Longo F.M., Yang T., et al. Small molecule approaches for promoting neurogenesis. Curr. Alzheimer Res. 3 1 (2006) 5-10
24. Lucarelli M., Borrelli V., et al. The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s). FEBS Lett. 522 1-3 (2002) 19-23
25. Mazzone T., Basheeruddin K., et al. Inhibitors of translation induce low-density lipoprotein receptor gene expression in human skin fibroblasts. J. Biol. Chem. 264 26 (1989) 15529-15534
26. Meresse S., Delbart C., et al. Low-density lipoprotein receptor on endothelium of brain capillaries. J. Neurochem. 53 2 (1989) 340-345
27. Miyake Y., Tajima S., et al. Analysis of a recycling-impaired mutant of low-density lipoprotein receptor in familial hypercholesterolemia. J. Biol. Chem. 264 28 (1989) 16584-16590
28. Mulder M., de Wit E., et al. The binding of human lipoprotein lipase treated VLDL by the human hepatoma cell line HepG2. Biochim. Biophys. Acta 1081 3 (1991) 308-314
29. Mulder M., Lombardi P., et al. Low-density lipoprotein receptor internalizes low-density and very low-density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase. J. Biol. Chem. 268 13 (1993) 9369-9375
30. Mulder M., Jansen P.J., et al. Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiol. Dis. 16 1 (2004) 212-219
31. Oh J., Choi Y.S., et al. Inhibition of low-density lipoprotein receptor expression by long-term exposure to phorbol ester via p38 mitogen-activated protein kinase pathway. J. Cell. Biochem. 96 4 (2005) 786-794
32. Osono Y., Woollett L.A., et al. Role of the low-density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. J. Clin. Invest. 95 3 (1995) 1124-1132
33. Pak Y.K., Kanuck M.P., et al. Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor. J. Lipid Res. 37 5 (1996) 985-998
34. Panza F., D'Introno A., et al. Lipid metabolism in cognitive decline and dementia. Brain Res. Brain Res. Rev. 51 2 (2006) 275-292
35. Paradis E., Clement S., et al. Lipoprotein lipase affects the survival and differentiation of neural cells exposed to very low density lipoprotein. J. Biol. Chem. 278 11 (2003) 9698-9705
36. Paradis E., Julien P., et al. Requirement for enzymatically active lipoprotein lipase in neuronal differentiation: a site-directed mutagenesis study. Brain Res. Dev. Brain Res. 149 1 (2004) 29-37
37. Pavlov O.V., Bobryshev Yu V., et al. An in vitro study of the effects of lovastatin on human fetal brain cells. Neurotoxicol. Teratol. 17 1 (1995) 31-39
38. Posse De Chaves E.I., Vance D.E., et al. Uptake of lipoproteins for axonal growth of sympathetic neurons. J. Biol. Chem. 275 26 (2000) 19883-19890
39. Prickaerts J., Koopmans G., et al. Learning and adult neurogenesis: survival with or without proliferation?. Neurobiol. Learn. Mem. 81 1 (2004) 1-11
40. Puglielli L., Konopka G., et al. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat. Cell Biol. 3 10 (2001) 905-912
41. Qiu S., Korwek K.M., et al. A fresh look at an ancient receptor family: emerging roles for low-density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiol. Learn. Mem. 85 1 (2006) 16-29
42. Sargent M.G. Fiftyfold amplification of the Lowry protein assay. Anal. Biochem. 163 2 (1987) 476-481
43. Scott J. RNA editing: a novel mechanism for the regulation of dietary cholesterol absorption The Humphry Davy Rolleston lecture 1989. J. R. Coll. Physicians Lond. 24 2 (1990) 101-106
44. Semenkovich C.F., and Ostlund Jr. R.E. Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line HepG2. Biochemistry 26 16 (1987) 4987-4992
45. Shankaran M., King C., et al. Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique. J. Pharmacol. Exp. Ther. 319 3 (2006) 1172-1181
46. Swanson L.W., Simmons D.M., et al. Localization of mRNA for low-density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridisation. Proc. Natl. Acad. Sci. U.S.A. 85 24 (1988) 9821-9825
47. Wade D.P., Knight B.L., et al. Hormonal regulation of low-density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells Insulin increases LDL receptor activity and diminishes its suppression by exogenous LDL. Eur. J. Biochem. 174 1 (1988) 213-218
48. Wolozin B. Cholesterol and the biology of Alzheimer's disease. Neuron 41 1 (2004) 7-10
49. Wolozin B., Kellman W., et al. Decreased prevalence of Alzheimer's disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57 10 (2000) 1439-1443
50. Xiong G.L., Benson A., et al. Statins and cognition: what can we learn from existing randomized trials?. CNS Spectr. 10 11 (2005) 867-874
51. Yamada H., Kurata H., et al. Adult xanthogranulomatous intracranial lesion involving familial hypercholesterolemia. Jpn. J. Med. 28 6 (1989) 757-761
52. Zhang B., Shimoji E., et al. Evaluation of apolipoprotein A-I kinetics in rabbits in vivo using in situ and exogenous radioiodination methods. Lipids 38 3 (2003) 209-218