Increased locomotor activity in mice lacking the low-density lipoprotein receptor

Behavioural Brain Research

Volumn 191, Issue 2, 2008, Pages 256-265

  Elder, Gregory A ^a,b   Ragnauth, Andre ^a,b   Dorr, Nathan ^a,b   Franciosi, Sonia ^a,b   Schmeidler, James ^a   Haroutunian, Vahram ^a,b   Buxbaum, Joseph D ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acoustic startle; Alzheimer's disease; Cholesterol; Light dark preference; Low density lipoprotein receptor; Morris water maze; Null mutation; Open field

Indexed keywords

CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; C57BL 6 MOUSE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CONTROLLED STUDY; LIGHT DARK CYCLE; LIPID BLOOD LEVEL; LOCOMOTION; MALE; MAZE TEST; MOUSE; MUTATION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SENSORIMOTOR FUNCTION; SPATIAL MEMORY;

ACOUSTIC STIMULATION; ADAPTATION, PSYCHOLOGICAL; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BODY SIZE; BODY WEIGHT; CHOLESTEROL; EXPLORATORY BEHAVIOR; INHIBITION (PSYCHOLOGY); LOCOMOTION; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LDL; STARTLE REACTION;

EID: 43849109491     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.03.036     Document Type: Article

References (32)

1. Beeri M.S., Rapp M., Silverman J.M., Schmeidler J., Grossman H.T., Fallon J.T., et al. Coronary artery disease is associated with Alzheimer disease neuropathology in apoe4 carriers. Neurology 66 (2006) 1399-1404
2. Breslow J.L. Mouse models of atherosclerosis. Science 272 (1996) 685-688
3. Breteler M.M. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 21 (2000) 153-160
4. Brown M.S., and Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 232 (1986) 34-47
5. Casserly I., and Topol E. Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 363 (2004) 1139-1146
6. Crawley J.N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 835 (1999) 18-26
7. Crawley J.N., and Davis L.G. Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains. Brain Res Bull 8 (1982) 609-612
8. Defesche J.C. Low-density lipoprotein receptor-its structure, function, and mutations. Semin Vasc Med 4 (2004) 5-11
9. Dehouck B., Dehouck M.P., Fruchart J.C., and Cecchelli R. Upregulation of the low density lipoprotein receptor at the blood-brain barrier: Intercommunications between brain capillary endothelial cells and astrocytes. J Cell Biol 126 (1994) 465-473
10. Dehouck B., Fenart L., Dehouck M.P., Pierce A., Torpier G., and Cecchelli R. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J Cell Biol 138 (1997) 877-889
11. Elder G.A., Cho J.Y., English D.F., Franciosi S., Schmeidler J., Gama Sosa M.A., et al. Elevated plasma cholesterol does not affect brain Aβ in mice lacking the low-density lipoprotein receptor. J Neurochem 102 (2007) 1220-1231
12. Fryer J.D., Demattos R.B., McCormick L.M., O'Dell M.A., Spinner M.L., Bales K.R., et al. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J Biol Chem 280 (2005) 25754-25759
13. Herz J., and Bock H.H. Lipoprotein receptors in the nervous system. Annu Rev Biochem 71 (2002) 405-434
14. Herz J., Gotthardt M., and Willnow T.E. Cellular signaling by lipoprotein receptors. Curr Opin Lipidol 11 (2000) 161-166
15. Hofmann S.L., Russell D.W., Goldstein J.L., and Brown M.S. mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits. Proc Natl Acad Sci USA 84 (1987) 6312-6316
16. Ishibashi S., Brown M.S., Goldstein J.L., Gerard R.D., Hammer R.E., and Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92 (1993) 883-893
17. Ishibashi S., Goldstein J.L., Brown M.S., Herz J., and Burns D.K. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 93 (1994) 1885-1893
18. Jeon H., and Blacklow S.C. Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 74 (2005) 535-562
19. Kamada H., Hayashi T., Sato K., Iwai M., Nagano I., Shoji M., et al. Up-regulation of low-density lipoprotein receptor expression in the ischemic core and the peri-ischemic area after transient MCA occlusion in rats. Brain Res Mol Brain Res 134 (2005) 181-188
20. Knowles J.W., and Maeda N. Genetic modifiers of atherosclerosis in mice. Arterioscler Thromb Vasc Biol 20 (2000) 2336-2345
21. Lesser G., Kandiah K., Libow L.S., Likourezos A., Breuer B., Marin D., et al. Elevated serum total and LDL cholesterol in very old patients with Alzheimer's disease. Dement Geriatr Cogn Disord 12 (2001) 138-145
22. Lucarelli M., Gennarelli M., Cardelli P., Novelli G., Scarpa S., Dallapiccola B., et al. Expression of receptors for native and chemically modified low-density lipoproteins in brain microvessels. FEBS Lett 401 (1997) 53-58
23. Mulder M., Jansen P.J., Janssen B.J., van de Berg W.D., van der Boom H., Havekes L.M., et al. Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiol Dis 16 (2004) 212-219
24. Paylor R., and Crawley J.N. Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (Berl) 132 (1997) 169-180
25. Pitas R.E., Boyles J.K., Lee S.H., Hui D., and Weisgraber K.H. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J Biol Chem 262 (1987) 14352-14360
26. Powell-Braxton L., Veniant M., Latvala R.D., Hirano K.I., Won W.B., Ross J., et al. A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet. Nat Med 4 (1998) 934-938
27. Rogers D.C., Fisher E.M., Brown S.D., Peters J., Hunter A.J., and Martin J.E. Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 8 (1997) 711-713
28. Shobab L.A., Hsiung G.Y., and Feldman H.H. Cholesterol in Alzheimer's disease. Lancet Neurol 4 (2005) 841-852
29. Snowdon D.A., Greiner L.H., Mortimer J.A., Riley K.P., Greiner P.A., and Markesbery W.R. Brain infarction and the clinical expression of Alzheimer disease. The nun study. JAMA 277 (1997) 813-817
30. Swanson L.W., Simmons D.M., Hofmann S.L., Goldstein J.L., and Brown M.S. Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization. Proc Natl Acad Sci USA 85 (1988) 9821-9825
31. Teupser D., Persky A.D., and Breslow J.L. Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement). Arterioscler Thromb Vasc Biol 23 (2003) 1907-1913
32. Wolozin B. Cholesterol, statins and dementia. Curr Opin Lipidol 15 (2004) 667-672