The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 4, 2015, Pages 969-975

  Bond, Silas ^a   Draffan, Alistair G ^a   Fenner, Jennifer E ^a   Lambert, John ^a   Lim, Chin Yu ^a   Lin, Bo ^a   Luttick, Angela ^a   Mitchell, Jeffrey P ^a   Morton, Craig J ^a   Nearn, Roland H ^a   Sanford, Vanessa ^a   Stanislawski, Pauline C ^a   Tucker, Simon P ^a  

^a Biota Scientific Management Pty Ltd   (Australia)

Author keywords

Antiviral; Respiratory syncytial virus; Synthesis

Indexed keywords

1 CYCLOPROPYL 1,3 DIHYDRO 3 [[1 (4 HYDROXYBUTYL) 1H BENZIMIDAZOL 2 YL]METHYL] 2H IMIDAZO[4,5 C]PYRIDIN 2 ONE; 1,2,3,9 B TETRAHYDRO 5H IMIDAZO[2,1 A]ISOINDOL 5 ONE; ISOINDOLE DERIVATIVE; MDT 637; NITROGEN; RESPIRATORY SYNCYTIAL VIRUS FUSION INHIBITOR; TMC 353121; UNCLASSIFIED DRUG; VIRUS FUSION INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SOLUBILITY; ELIMINATION HALF-LIFE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN BINDING; RAT; STRUCTURE ACTIVITY RELATION; VIRUS STRAIN; VOLUME OF DISTRIBUTION;

RATTUS; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 84964309742     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.018     Document Type: Article

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