1,4-Benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate

Journal of Medicinal Chemistry

Volumn 50, Issue 7, 2007, Pages 1685-1692

  Henderson, Elisa A ^a   Alber, Dagmar G ^a   Baxter, Robert C ^a   Bithell, Sian K ^a   Budworth, Joanna ^a   Carter, Malcolm C ^a   Chubb, Ann ^a   Cockerill, G Stuart ^a   Dowdell, Verity C L ^a   Fraser, Ian J ^a   Harris, Robert A ^a   Keegan, Sally J ^a   Kelsey, Richard D ^a   Lumley, James A ^a   Stables, Jeremy N ^a   Weerasekera, Natasha ^a   Wilson, Lara J ^a   Powell, Kenneth L ^a  

^a Arrow Therapeutics   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 FLUOROPHENYL) 3 (2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 YL)UREA; 4 METHANESULFONYL 2 METHOXY N (2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 YL)BENZAMIDE; A 315; ANTIVIRUS AGENT; BENZODIAZEPINE DERIVATIVE; RSV 604; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; RAT; REACTION ANALYSIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIVIRAL AGENTS; BENZODIAZEPINES; BENZODIAZEPINONES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MICROSOMES; MOLECULAR STRUCTURE; PHENYLUREA COMPOUNDS; PLAQUE ASSAY; RATS; RESPIRATORY SYNCYTIAL VIRUSES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34147092093     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060747l     Document Type: Article

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