The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect

International Journal of Radiation Biology

Volumn 91, Issue 4, 2015, Pages 368-378

  Zhang, Tingting ^a   Shen, Yijun ^b   Chen, Ying ^c   Hsieh, Jer Tsong ^d   Kong, Zhaolu ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c Huai'An Women and Children's Hospital   (China)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

ATM; Bladder cancer; DAB2IP; KU55933; Radiotresistance

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; NU 7026; RAD51 PROTEIN; RADIOSENSITIZING AGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLADDER CANCER; BLADDER CANCER CELL LINE; CANCER CELL; CELL CYCLE S PHASE; CELL SURVIVAL; CLONOGENESIS; COLONY FORMATION; CONTROLLED STUDY; DAB2IP GENE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION RESPONSE; RADIOSENSITIVITY; RADIOSENSITIZATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 84964309639     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2015.1001531     Document Type: Article

References (32)

1. Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D. 2004. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene 23 : 7691-7700.
2. Chen H, Pong RC, Wang Z, Hsieh JT. 2002. Diff erential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: Cloning and characterization. Genomics 79 : 573-581.
3. Dote H, Toyooka S, Tsukuda K, Yano M, Ota T, Murakami M, Naito M, Toyota M, Gazdar AF, Shimizu N. 2005. Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. Br J Cancer 92: 1117-1125.
4. Dote H, Toyooka S, Tsukuda K, Yano M, Ouchida M, Doihara H, Suzuki M, Chen H, Hsieh JT, Gazdar AF, et al. 2004. Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Clin Cancer Res 10 : 2082-2089.
5. Durant ST, Nickoloff JA. 2005. Good timing in the cell cycle for precise DNA repair by BRCA1. Cell Cycle 4 : 1216-1222.
6. Gapud EJ, Sleckman BP. 2011. Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell Cycle 10 : 1928-1935.
7. Hicksoni, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. 2004.identifi cation and characterization of a novel and specifi c inhibitor of the ataxiatelangiectasia mutated kinase ATM. Cancer Res 64: 9152-9159.
8. Hinata N, Shirakawa T, Zhang Z, Matsumoto A, Fujisawa M, Okada H, Kamidono S, Gotoh A. 2003. Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type- p53 but not in p53- mutated bladder cancer cells. Urol Res 31: 387-396.
9. Kobayashi J,iwabuchi K, Miyagawa K, Sonoda E, Suzuki K, Takata M, Tauchi H. 2008. Current topics in DNA double-strand break repair. J Radiat Res 49: 93-103.
10. Kong Z, Raghavan P, Xie D, Boike T, Burma S, Chen D, Chakraborty A, Hsieh JT, Saha D. 2010a. Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells.int J Radiat Oncol Biol Phys 78: 1210-1218.
11. Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT, Saha D. 2010b. Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res 70: 2829-2839.
12. Koning CC, Blank LE, Koedooder C, van Os RM, van de Kar M, Jansen E, Battermann JJ, Beijert M, Gernaat C, van Herpen KA, et al. 2012. Brachytherapy after external beam radiotherapy and limited surgery preserves bladders for patients with solitary pT1-pT3 bladder tumors. Ann Oncol 23 : 2948-2953.
13. L ö brich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. 2010. gammaH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization. Cell Cycle 9 : 662-669.
14. Moyer VA. 2011. Screening for bladder cancer: U.S. Preventive Services Task Force recommendation statement. Annintern Med 155 : 246-251.
15. Pawlik TM, Keyomarsi K. 2004. Role of cell cycle in mediating sensitivity to radiotherapy.int J Radiat Oncol Biol Phys 59: 928-942.
16. Qiu GH, Xie H, Wheelhouse N, Harrison D, Chen GG, Salto-Tellez M, Lai P, Ross JA, Hooi SC. 2007. Diff erential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. J Hepatol 46 : 655-663.
17. Sandler HM, Mirhadi AJ. 2012. Current role of radiation therapy for bladder cancer. Semin Oncol 39: 583-587.
18. Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. 2000. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 151: 1381-1390.
19. Shen YJ, Kong ZL, Wan FN, Wang HK, Bian XJ, Gan HL, Wang CF, Ye DW. 2014. Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer. Cancer Sci 105: 704-712.
20. Shrivastav M, De Haro LP, Nickoloff JA. 2008. Regulation of DNA double-strand break repair pathway choice. Cell Res 18: 134-147.
21. Shrivastav M, Miller CA, De Haro LP, Durant ST, Chen BP, Chen DJ, Nickoloff JA. 2009. DNA-PKcs and ATM co-regulate DNA doublestrand break repair. DNA Repair (Amst) 8: 920-929.
22. Siegel R, Naishadham D, Jemal A. 2013. Cancer statistics, 2013. CA Cancer J Clin 63 : 11-30.
23. Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Th angathurai D, Mikhail M, et al. 2001. Radical cystectomy in the treatment of invasive bladder cancer: Long-term results in 1,054 patients. J Clin Oncol 19 : 666-675.
24. Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. 2003. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADPribose) polymerase-1. Cancer Res 63 : 6008-6015.
25. Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT. 2002. The mechanism of growth-inhibitory eff ect of DOC-2/ DAB2 in prostate cancer. Characterization of a novel GTPaseactivating protein associated with N-terminal domain of DOC-2/ DAB2. J Biol Chem 277 : 12622-12631.
26. White D, Rafalska-MetcalfiU,ivanov AV, Corsinotti A, Peng H, Lee SC, Trono D, Janicki SM, Rauscher FJ 3rd. 2012. The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and serine 473/824 phosphorylation. Mol Cancer Res 10 : 401-414.
27. Xie D, Gore C, Liu J, Pong RC, Mason R, Hao G, Long M, Kabbani W, Yu L, Zhang H, et al. 2010. Role of DAB2IP in modulating epithelialto- mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci USA 107 : 2485-2490.
28. Xie D, Gore C, Zhou J, Pong RC, Zhang H, Yu L, Vessella RL, Min W, Hsieh JT. 2009. DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci USA 106 : 19878-19883.
29. Yafi FA, Aprikian AG, Chin JL, Fradet Y,izawa J, Estey E, Fairey A, Rendon R, Cagiannosi, Lacombe L, et al. 2011. Contemporary outcomes of 2287 patients with bladder cancer who were treated with radical cystectomy: A Canadian multicentre experience. BJU Int 108 : 539-545.
30. Yano M, Toyooka S, Tsukuda K, Dote H, Ouchida M, Hanabata T, Aoe M, Date H, Gazdar AF, Shimizu N. 2005. Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers.int J Cancer 113: 59-66.
31. Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. 2002. SMC1 is a downstream eff ector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 16: 571-582.
32. Zhang H, Zhang R, Luo Y, D ' Alessio A, Pober JS, Min W. 2004. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem 279: 44955-44965.