The effect of clinically therapeutic plasma concentrations of lidocaine on natural killer cell cytotoxicity

Regional Anesthesia and Pain Medicine

Volumn 40, Issue 1, 2015, Pages 43-48

  Ramirez, Maria F ^a   Tran, Peter ^b   Cata, Juan P ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Department of Cancer Systems Imaging ^*  (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GAMMA INTERFERON; GRANZYME B; LIDOCAINE; NATURAL KILLER CELL RECEPTOR NKG2D; PERFORIN;

ARTICLE; CELL ACTIVITY; CELL FUNCTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG EFFECT; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION;

EID: 84964306109     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0000000000000191     Document Type: Article

References (21)

1. Lahav M, Levite M, Bassani L, et al. Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells. Clin Exp Immunol. 2002;127:226-233.
2. Lahat A, Ben-Horin S, Horin S, et al. Lidocaine down-regulates nuclear factor-kappaB signalling and inhibits cytokine production and T cell proliferation. Clin Exp Immunol. 2008;152:320-327.
3. Melamed R, Bar-Yosef S, Shakhar G, Shakhar K, Ben-Eliyahu S. Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. Anesth Analg. 2003;97: 1331-1339.
4. Cata JP, Bauer M, Sokari T, et al. Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer. J Clin Anesth. 2013;25:255-262.
5. Krog J, Hokland M, Ahlburg P, Parner E, Tonnesen E. Lipid solubility- and concentration-dependent attenuation of in vitro natural killer cell cytotoxicity by local anesthetics. Acta Anaesthesiol Scand. 2002;46: 875-881.
6. Takagi S, Kitagawa S, Oshimi K, Takaku F, Miura Y. Effect of local anaesthetics on human natural killer cell activity. Clin Exp Immunol. 1983; 53:477-481.
7. Grillo J, Venitz J, Ornato J. Prediction of lidocaine tissue concentrations following different dose regimes during cardiac arrest using a physiologically based pharmacokinetic model. Resuscitation. 2001;50:331-340.
8. Li CY, Tsai CS, Hsu PC, Chueh SH, Wong CS, Ho ST. Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation. Anesth Analg. 2003;97:1312-1316.
9. Yardeni IZ, Beilin B, Mayburd E, Levinson Y, Bessler H. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth Analg. 2009;109:1464-1469.
10. Yokoyama M, Itano Y, Mizobuchi S, et al. The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain. Anesth Analg. 2001;92:463-469.
11. Yang W, Geng Y, Liu Y, et al. Comparison of effects of thoracic epidural and intravenous administration of lidocaine on target-controlled infusion of propofol and tracheal intubation response during induction of anesthesia. J Cardiothorac Vasc Anesth. 2013;27:1295-1300.
12. Mitsuhata H, Masaki Y, Matsumoto S, Shigeomi S, Enzan K, Hasegawa J. Effects of local anesthetics upon human natural killer cytotoxicity in vitro [In Japanese]. Masui. 1991;40:1674-1681.
13. Andre P, Castriconi R, Espeli M, et al. Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur J Immunol. 2004;34:961-971.
14. Zafirova B, Wensveen FM, Gulin M, Polic B. Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci. 2011;68:3519-3529.
15. Hervieu A, Mignot G, Ghiringhelli F. Dacarbazine mediate antimelanoma effects via NK cells. Oncoimmunology. 2013;2:e23714.
16. + channels. A pharmacologic flow cytometric study. J Immunol. 1990;144:2365-2370.
17. Beyder A, Strege PR, Bernard C, Farrugia G. Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity. Channels (Austin). 2012;6:308-316.
18. Li C, Ge B, Nicotra M, et al. JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2008;105:3017-3022.
19. Do SH, Fang HY, Ham BM, Zuo Z. The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase. Anesth Analg. 2002;95:1263-1268.
20. Verhoeven DH, de Hooge AS, Mooiman EC, et al. NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways. Mol Immunol. 2008;45:3917-3925.
21. + tumor cells. Clin Cancer Res. 2008;14: 4650-4657.