Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex

Oncogene

Volumn 35, Issue 43, 2016, Pages 5629-5640

  Powley, I R ^a   Hughes, M A ^a   Cain, K ^a   MaCfarlane, M ^a  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FAS ANTIGEN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 6; PROCASPASE 8; PROTEIN TYROSINE KINASE; TYROSINE;

APOPTOSIS; ARTICLE; BIOASSAY; CELL LYSATE; CELL MATURATION; CELL MIGRATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE OVEREXPRESSION; HOMODIMERIZATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NEUROBLASTOMA CELL LINE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE; WOUND HEALING ASSAY; BIOLOGICAL MODEL; CHEMISTRY; ENZYME ACTIVATION; GENETICS; JURKAT CELL LINE; METABOLISM; MOLECULAR MODEL; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTIGENS, CD95; APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEOLYSIS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE;

EID: 84964296704     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2016.99     Document Type: Article

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