Design and synthesis of new bioisosteres of spirooxindoles (MI-63/219) as anti-breast cancer agents

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 4, 2015, Pages 839-848

  Kumar, Atul ^a,c   Gupta, Garima ^a   Bishnoi, Ajay Kumar ^a,c   Saxena, Ruchi ^a   Saini, Karan Singh ^a   Konwar, Rituraj ^a   Kumar, Sandeep ^b   Dwivedi, Anila ^a,c  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

^c ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

Anticancer agents; Bioisosteres; Breast cancer; MDM2 p53; Spirooxindoles

Indexed keywords

1 ETHYL 3' [4 (2 MORPHOLINOETHOXY)BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' (4 NITROBENZOYL) 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' BENZOYL 4' (4 HYDROXYPHENYL) 5' PHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' BENZOYL 4' (4 METHOXYPHENYL) 5' PHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' [4 (2 MORPHOLINOETHOXY)BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' [4 (2 MORPHOLINOETHOXY)BENZOYL] 5 NITRO 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' [4 [1 (DIMETHYLAMINO)PROPAN 2 YLOXY]BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' [4 [2 (DIETHYLAMINO)ETHOXY]BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' [4 [2 (DIMETHYLAMINO)ETHOXY]BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 3' [4 [3 (DIMETHYLAMINO)PROPOXY]BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 4',5' DIPHENYL 3' [4 [2 (PIPERIDIN 1 YL)ETHOXY]BENZOYL]SPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 4',5' DIPHENYL 3' [4 [2 (PYRROLIDIN 1 YL)ETHOXY]BENZOYL]SPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 5 CHLORO 3' [4 (2 MORPHOLINOETHOXY)BENZOYL] 4',5' DIPHENYLSPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 5 CHLORO 4',5' DIPHENYL 3' [4 [2 (PIPERIDIN 1 YL)ETHOXY]BENZOYL]SPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; 5 NITRO 4',5' DIPHENYL 3' [4 [2 (PIPERIDIN 1 YL)ETHOXY]BENZOYL]SPIRO[INDOLINE 3,2' PYRROLIDIN] 2 ONE; ANTINEOPLASTIC AGENT; CYCLIN D1; INDOLE DERIVATIVE; NUTLIN 3; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; SPIROOXINDOLE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CYCLE REGULATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TUMOR XENOGRAFT;

MUS MUSCULUS;

EID: 84964290978     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.12.037     Document Type: Article

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