Protective effects of L-carnosine on CCl4 -induced hepatic injury in rats

European Cytokine Network

Volumn 27, Issue 1, 2016, Pages 6-15

  Alsheblak, Mehyar Mohammad ^a   Elsherbiny, Nehal M ^a   El Karef, Amro ^b   El Shishtawy, Mamdouh M ^a  

^a MANSOURA UNIVERSITY   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Carnosine; CCl 4 induced hepatic injury; Nrf2; SMA

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; CARNOSINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; INTERLEUKIN 10; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; ACTIN; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CARBON TETRACHLORIDE INDUCED HEPATIC INJURY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL LIVER INJURY; HEPATITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SPECTROPHOTOMETRY; STELLATE CELL; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION; GENETICS; INFLAMMATION; LIVER CIRRHOSIS; LIVER FUNCTION TEST; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TOXIC HEPATITIS;

ACTINS; ANIMALS; BIOMARKERS; CARBON TETRACHLORIDE; CARNOSINE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DISEASE MODELS, ANIMAL; GENE EXPRESSION; INFLAMMATION; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; MODELS, BIOLOGICAL; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; SUPEROXIDE DISMUTASE;

EID: 84964285282     PISSN: 11485493     EISSN: 19524005     Source Type: Journal    
DOI: 10.1684/ecn.2016.0372     Document Type: Article

References (58)

1. Huang X, Wang X, Lv Y, Xu L, Lin J, Diao Y. Protection effect of kallistatin on carbon tetrachloride-induced liver fibrosis in rats via antioxidative stress. PLoS One 2014; 18: 9.
2. Balsano C, Alisi A, Nobili V. Liver fibrosis and therapeutic strategies: the goal for improving metabolism. Curr Drug Targets 2009; 10: 505-12.
3. Luedde T, Schwabe RF. NF-B in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 2011; 8: 108-18.
4. Gäbele E, Brenner DA, Rippe RA. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci 2003; 1: 69-77.
5. Zhou WC, Zhang QB, Qiao L. Pathogenesis of liver cirrhosis. World J Gastroenterol 2014; 20: 7312-24.
6. Brenner DA. Molecular pathogenesis of liver fibrosis. Trans Am Clin Climatol Assoc 2009; 120: 361-8.
7. Tan Z, Qian X, Jiang R, et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol 2013; 191: 1835-44.
8. Zhao X, Song JL, Kil JH, Park KY. Bamboo salt attenuates CCl4-induced hepatic damage in Sprague-Dawley rats. Nutr Res Pract 2013; 7: 273-80.
9. Yeh YH, Hsieh YL, Lee YT. Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats. J Agric Food Chem 2013; 61: 7387-96.
10. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33: 105-36.
11. Kumar H, Kim IS, More SV, Kim BW, Choi DK. Natural productderived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Nat Prod Rep 2014; 31: 109-39.
12. Scannevin RH, Chollate S, Jung MY, et al. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther 2012; 341: 274-84.
13. Ditte Z, Ditte P, Labudova M, et al. Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts. BMC Cancer 2014: 14-358.
14. Zhang Z, Miao L, Wu X, et al. Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling. J Cancer 2014; 5: 382-9.
15. Aydin AF, Küskü-Kiraz Z, Doğru-Abbasoğlu S, Güllüoğlu M, Uysal M, Koçak-Toker N. Effect of carnosine against thioacetamide-induced liver cirrhosis in rat. Peptides 2010; 31: 67-71.
16. Rashid I, van Reyk DM, Davies MJ. Carnosine and its constituents inhibit glycation of low- density lipoproteins that promots foamcell formation in vitro. FEBS Lett 2007; 581: 1067-70.
17. Riedl E, Pfister F, Braunagel M, et al. Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats. Cell Physiol Biochem 2011; 28: 279-88.
18. Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 2001; 122: 1431-45.
19. Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E. Neuroprotective features of carnosine in oxidative driven diseases. Mol Aspects Med 2011; 32: 258-66.
20. Hipkiss AR. Could carnosine or related structures suppress Alzheimer’s disease? J Alzheimers Dis 2007; 11: 229-40.
21. Artun BC, Küskü-Kiraz Z, Güllüoğlu M, Cevikba¸ U, Koçak-Toker N, Uysal M. The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats. Hum Exp Toxicol 2010; 29: 659-65.
22. Giri¸ M, Doğru-Abbasoğlu S, Kumral A, Olgaç V, Koçak-Toker N, Uysal M. Effect of carnosine alone or combined with –tocopherol on hepatic steatosis and oxidative stress in fructose-induced insulin- resistant rats. J Physiol Biochem 2014; 70: 385-95.
23. Mehmetçik G, Ozdemirler G, Koçak-Toker N, Cevikba¸ U, Uysal M. Role of carnosine in preventing thioacetamide-induced liver injury in the rat. Peptides 2008; 29: 425.
24. Aydín AF, Küskü-Kiraz Z, Doğru-Abbasoğlu S, Uysal M. Effect of carnosine treatment on oxidative stress in serum, apoB-containing lipoproteins fraction and erythrocytes of aged rats. Pharmacol Rep 2010: 733-9.
25. Elsherbiny NM, Abd El Galil KH, Gabr MM, Al-Gayyar MM, Eissa LA, El-Shishtawy MM. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw 2012; 23: 78-86.
26. DeChatelet LR, McCall CE, McPhail LC, Johnston Jr. RB. Superoxide dismutase activity in leukocytes. J Clin Invest 1974; 53: 1197-201.
27. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82: 70-7.
28. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-9.
29. Maheshwari DT, Yogendra Kumar MS, Verma SK, Singh VK, Singh SN. Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol 2011; 49: 2422-8.
30. Singh N, Kamath V, Narasimhamurthy K, Rajini PS. Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats. Environ Toxicol Pharmacol 2008; 26: 241-6.
31. Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY. Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol 2010; 242: 318-25.
32. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33: 105-36.
33. Ma JQ, Ding J, Zhang L, Liu CM. Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway. Clin Res Hepatol Gastroenterol 2015; 39: 188-97.
34. Martin-Aragón S, de las Heras B, Sanchez-Reus MI, Benedi J. Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes. Exp Toxicol Pathol 2001; 53: 199-206.
35. Feng Y, Siu KY, Ye X, et al. Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med 2010; 18: 5-33.
36. Al-Olayan EM, El-Khadragy MF, Aref AM, Othman MS, Kassab RB, Abdel Moneim AE. The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression. Oxid Med Cell Longev 2014; 2014: 381413.
37. Kim MY, Kim EJ, Kim YN, Choi C, Lee BH. Effects of –lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats. Nutr Res Pract 2011; 5: 421-8.
38. Kumar H, Kim IS, More SV, Kim BW, Choi DK. Natural productderived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Nat Prod Rep 2014; 31: 109-39.
39. Xu W, Hellerbrand C, Köhler UA, Bugnon P, et al. The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest 2008; 88: 1068-78.
40. Wu S, Yue Y, Tian H, et al. Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl-induced liver damage in rats via the Nrf2 pathway. J Ethnopharmacol 2013; 148: 570-8.
41. Li JP, Gao Y, Chu SF, et al. Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol-and CCl4-induced hepatic fibrosis. Acta Pharmacol Sin 2014; 35: 1031-44.
42. Li N, Xia T, Nel AE. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 2008; 44: 1689-99.
43. Niture SK, Kaspar JW, Shen J, Jaiswal AK. Nrf2 signaling and cell survival. Toxicol Appl Pharmacol 2010; 244: 37-42.
44. Rocha SW, de França ME, Rodrigues GB, et al. Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride-(CCl4-) induced liver injury in mice. Mediators Inflamm 2014; 2014: 696383.
45. Shin DS, Kim KW, Chung HY, Yoon S, Moon JO. Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats. Arch Pharm Res 2013; 36: 626-33.
46. O’Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008; 28: 477-87.
47. Arai T, Hiromatsu K, Kobayashi N, et al. IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. J Immunol 1995; 155: 5743-9.
48. Son DO, Satsu H, Kiso Y, Totsuka M, Shimizu M. Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation. Cytokine. 2008; 42: 265-76.
49. Sahin S, Oter S, Burukoğlu D, Sutken E. The effects of carnosine in an experimental rat model of septic shock. Med Sci Monit Basic Res 2013; 19: 54-61.
50. Al-Shabanah OA, Alam K, Nagi MN, Al-Rikabi AC, Al-Bekairi AM. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci 2000; 66: 265-70.
51. Coleman JW. Nitric oxide in immunity and inflammation. Int Immunopharmacol 2001; 1: 1397-406.
52. Chen T, Zamora R, Zuckerbraun B, Billiar TR. Role of nitric oxide in liver injury. Curr Mol Med 2003; 3: 519-26.
53. Teraoka R, Shimada T, Aburada M. The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury. Biol Pharm Bull 2012; 35: 171-7.
54. Xiao J, Liong EC, Ching YP, et al. Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J Ethnopharmacol 2012; 139: 462-70.
55. De Minicis S, Rychlicki C, Agostinelli L, et al. Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis. Am J Pathol 2013; 183: 820-30.
56. López-Reyes AG, Arroyo-Curras N, Cano BG, et al. Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury. Ann Hepatol 2008; 7: 130-5.
57. Soliman KM, Abdel Aziz M, Nassar YH, Abdel-Sattar S, El-Ansary A. Effects of carnosine on bilharzial infestation in hamsters: biochemical and histochemical studies. Comp Biochem Physiol B Biochem Mol Biol 2002; 131: 535-42.
58. Cuzzocrea S, Genovese T, Failla M, et al. Protective effect of orally administered carnosine on bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2007; 292: 1095-104