1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 4, 2015, Pages 976-981

  Bond, Silas ^a   Draffan, Alistair G ^a   Fenner, Jennifer E ^a   Lambert, John ^a   Lim, Chin Yu ^a   Lin, Bo ^a   Luttick, Angela ^a   Mitchell, Jeffrey P ^a   Morton, Craig J ^a   Nearn, Roland H ^a   Sanford, Vanessa ^a   Anderson, Kelly H ^a   Mayes, Penelope A ^a   Tucker, Simon P ^a  

^a Biota Scientific Management Pty Ltd   (Australia)

Author keywords

Antiviral; Respiratory syncytial virus; Synthesis

Indexed keywords

BTA 9881; UNCLASSIFIED DRUG; VIRUS FUSION INHIBITOR;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG STRUCTURE; ENANTIOMER; HUMAN RESPIRATORY SYNCYTIAL VIRUS; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN BINDING; RAT; VIRUS REPLICATION; VOLUME OF DISTRIBUTION; X RAY CRYSTALLOGRAPHY;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 84964282399     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.024     Document Type: Article

References (18)

1. H. Nair, D.J. Nokes, B.D. Gessner, M. Dherani, S.A. Madhi, R.J. Singleton, K.L. O'Brien, A. Roca, P.F. Wright, N. Bruce, A. Chandran, E. Theodoratou, A. Sutanto, E.R. Sedyaningsih, M. Ngama, P.K. Munywoki, C. Kartasasmita, E.A.F. Simões, I. Rudan, M.W. Weber, and H. Campbell Lancet 375 2010 1545
2. A.R. Falsey, P.A. Hennessey, and M.A. Formica N. Engl. J. Med. 352 2005 1749 1759
3. U.S Food and Drug Administration. Palivizumab Product Approval Information - Licensing Action. www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/ucm093366.htm.
4. R.W. Steiner Am. Fam. Physician 69 2004 325
5. R.C. Welliver Curr. Opin. Pharmacol. 10 2010 289
6. J.L. Douglas, M.L. Panis, E. Ho, K.Y. Lin, S.H. Krawczyk, D.M. Grant, R. Cai, S. Swaminathan, and T. Cihlar J. Virol. 77 2003 5054
7. J.L. Douglas, M.L. Panis, E. Ho, K.Y. Lin, S.H. Krawczyk, D.M. Grant, R. Cai, S. Swaminathan, X. Chien, and T. Cihlar Antimicrob. Agents Chemother. 77 2005 2460
8. J.P. DeVincenzo, R.J. Whitley, R.L. Mackman, C. Scaglioni-Weinlich, L. Harrison, E. Farrell, S. McBride, R. Lambkin-Williams, R. Jordan, Y. Xin, S. Ramanathan, T. O'Riordan, S.A. Lewis, X. Li, S.L. Toback, S.-L. Lin, and J.W. Chien N. Engl. J. Med. 371 2014 711
9. S. Bond, A.G. Draffan, J. Fenner, J. Lambert, C.Y. Lim, B. Lin, A. Luttick, J.P. Mitchell, C. Morton, R.H. Nearn, V. Sanford, P.C. Stanislawski, and S.P. Tucker Bioorg. Med. Chem. Lett. 25 2014 969
10. A. Jozwiak, J.Z. Brzezinski, M.W. Plotka, A.K. Szczesniak, Z. Malinowski, and J. Epsztajn Eur. J. Org. Chem. 2004 3254
11. D.N. Bailey, and J.R. Briggs Ther. Drug Monit. 26 2004 40
12. Bond, S.; Sanford, V. A.; Lambert, J. N.; Lim, C. Y.; Mitchell, J. P.; Draffan, A. G.; Nearn, R. H. PCT Int. Appl. WO2005/061513.
13. F. Lombardo, M.Y. Shalaeva, K.A. Tupper, F. Gao, and M.H. Abraham J. Med. Chem. 43 2000 2922
14. C.D. Bevan, and R.S. Lloyd Anal. Chem. 72 2000 1781
15. C. Copéret, H. Adolfsson, T.-A.V. Khuong, A.K. Yudin, and K.B. Sharpless J. Org. Chem. 63 1998 1740
16. C. Cianci, K.-L. Yu, K. Combrink, N. Sin, B. Pearce, A. Wang, R. Civiello, S. Voss, G. Luo, K. Kadow, E.V. Genovesi, B. Venables, H. Gulgeze, A. Trehan, J. James, L. Lamb, I. Medina, J. Roach, Z. Yang, L. Zadjura, R. Colonno, J. Clark, N. Meanwell, and M. Krystal Antimicrob. Agents Chemother. 48 2004 413
17. J.-F. Bonfanti, C. Meyer, F. Doublet, J. Fortin, P. Muller, L. Queguiner, T. Gevers, P. Janssens, H. Szel, R. Willebrords, P. Timmerman, K. Wuyts, P. van Remoortere, F. Janssens, P. Wigerinck, and K. Andries J. Med. Chem. 51 2008 875
18. D. Roymans, H.L. De Bondt, E. Arnoult, P. Geluykens, T. Gevers, M. Van Ginderen, N. Verheyen, H. Kim, R. Willebrords, J.-F. Bonfanti, W. Bruinzeel, M.D. Cummings, H. van Vlijmen, and K. Andries PNAS 107 2010 308