Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber-enriched tube feed in hospitalized patients initiated on tube nutrition: Randomized controlled trial

Clinical Nutrition

Volumn 36, Issue 2, 2017, Pages 380-388

  Jakobsen, L H ^a   Wirth, R ^b,d   Smoliner, C ^b   Klebach, M ^c   Hofman, Z ^c   Kondrup, J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b St Marien Hospital Borken   (Germany)

^c Nutricia Advanced Medical Nutrition   (Netherlands)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Carotenoids; Diarrhea; Fiber; Fish oil; Gastrointestinal tolerance; Tube feeding

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; CAROTENOID; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LYCOPENE; PHOSPHOLIPID; XANTHOPHYLL; ZEAXANTHIN; LIPID EMULSION;

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BIOAVAILABILITY; BLOOD LEVEL; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DIETARY FIBER; DOUBLE BLIND PROCEDURE; ENTERIC FEEDING; ERYTHROCYTE MEMBRANE; FECES ANALYSIS; FEMALE; HOSPITAL PATIENT; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUTRIENT AVAILABILITY; PATIENT SAFETY; PHOSPHOLIPID BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RECTUM HEMORRHAGE; VOMITING; ADMINISTRATION AND DOSAGE; BLOOD; CHEMISTRY; CLINICAL TRIAL; DRUG EFFECTS; GASTROINTESTINAL TRACT; METABOLISM; MIDDLE AGED; NUTRITIONAL STATUS;

AGED; BIOLOGICAL AVAILABILITY; CAROTENOIDS; DIARRHEA; DIETARY FIBER; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; ENTERAL NUTRITION; FAT EMULSIONS, INTRAVENOUS; FEMALE; FISH OILS; GASTROINTESTINAL TRACT; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PHOSPHOLIPIDS;

EID: 84964267869     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2016.02.001     Document Type: Article

References (30)

1. [1] 1999/21/EC, C.D, Commission Directive 1999/21/EC of 25 March 1999 on dietary foods for special medical purposes. 1999.
2. [2] Whelan, K., Schneider, S.M., Mechanisms, prevention, and management of diarrhea in enteral nutrition. Curr Opin Gastroenterol 27:2 (2011), 152–159.
3. [3] Polage, C.R., Solnick, J.V., Cohen, S.H., Nosocomial diarrhea: evaluation and treatment of causes other than Clostridium difficile. Clin Infect Dis 55:7 (2012), 982–989.
4. [4] Elia, M., Engfer, M.B., Green, C.J., Silk, D.B., Systematic review and meta-analysis: the clinical and physiological effects of fibre-containing enteral formulae. Aliment Pharmacol Ther 27:2 (2008), 120–145.
5. [5] Bittencourt, A.F., Martins, J.R., Logullo, L., Shiroma, G., Horie, L., Ortolani, M.C., et al. Constipation is more frequent than diarrhea in patients fed exclusively by enteral nutrition: results of an observational study. Nutr Clin Pract 27:4 (2012), 533–539.
6. [6] Mozaffarian, D., Rimm, E.B., Fish intake, contaminants, and human health: evaluating the risks and the benefits. Jama 296:15 (2006), 1885–1899.
7. [7] Harris, W.S., Mozaffarian, D., Lefevre, M., Toner, C.D., Colombo, J., Cunnane, S.C., et al. Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids. J Nutr 139:4 (2009), 804s–819s.
8. [8] Arterburn, L.M., Hall, E.B., Oken, H., Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 83:6 Suppl (2006), 1467s–1476s.
9. [9] Munakata, M., Nishikawa, M., Togashi, N., Nio, E., Kobayashi, Y., Omura, K., et al. The nutrient formula containing eicosapentaenoic acid and docosahexaenoic acid benefits the fatty acid status of patients receiving long-term enteral nutrition. Tohoku J Exp Med 217:1 (2009), 23–28.
10. [10] Fiedor, J., Burda, K., Potential role of carotenoids as antioxidants in human health and disease. Nutrients 6:2 (2014), 466–488.
11. [11] Stahl, W., Sies, H., Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 1740:2 (2005), 101–107.
12. [12] Buijsse, B., Feskens, E.J., Schlettwein-Gsell, D., Ferry, M., Kok, F.J., Kromhout, D., et al. Plasma carotene and alpha-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the survey in Europe on nutrition and the elderly, a concerted action (SENECA). Am J Clin Nutr 82:4 (2005), 879–886.
13. [13] Shardell, M.D., Alley, D.E., Hicks, G.E., El-Kamary, S.S., Miller, R.R., Semba, R.D., et al. Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination Survey. Nutr Res (New York, NY) 31:3 (2011), 178–189.
14. [14] Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser, 2003, 916 i-viii, 1-149, backcover.
15. [15] Research, W.C.R.F.A.I.f.C., Food, nutrition, physical activity, and the prevention of Cancer: a global perspective. 2007, AICR, Washington DC.
16. [16] Van Leen, M., Safe use of a nutritionally improved tube feed. Clin Nutr Suppl, 5(Suppl. 2(PP 153)), 2010, 83.
17. [17] Longstreth, G.F., Thompson, W.G., Chey, W.D., Houghton, L.A., Mearin, F., Spiller, R.C., Functional bowel disorders. Gastroenterology 130:5 (2006), 1480–1491.
18. [18] Lewis, S.J., Heaton, K.W., Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 32:9 (1997), 920–924.
19. [19] de Kruif, J.T., Vos, A., The influence of soyfibre supplemented tube feeding on the occurrence of diarrhoea in postoperative patients. Clin Nutr 12:6 (1993), 360–364.
20. [20] van Aerde, J., et al. Tolerance and safety of energy-dense enteral formulae for young children. Int Paediatr 18:2 (2003), 95–99.
21. [21] Catafesta, J., Francesconi, C., Association between medication use and adverse gastroenterologic events in patients receiving enteral nutrition therapy at a University Hospital. Rev Gastroenterol Mex 77:4 (2012), 161–166.
22. [22] Thibault, R., Graf, S., Clerc, A., Delieuvin, N., Heidegger, C.P., Pichard, C., Diarrhoea in the ICU: respective contribution of feeding and antibiotics. Crit Care, 17(4), 2013, R153.
23. [23] Stein, A., Voigt, W., Jordan, K., Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol 2:1 (2010), 51–63.
24. [24] Olza, J., Mesa, M.D., Aguilera, C.M., Moreno-Torres, R., Jimenez, A., Perez de la Cruz, A., et al. Influence of an eicosapentaenoic and docosahexaenoic acid-enriched enteral nutrition formula on plasma fatty acid composition and biomarkers of insulin resistance in the elderly. Clin Nutr 29:1 (2010), 31–37.
25. [25] Vaisman, N., et al. Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients. Clin Nutr 25:6 (2006), 897–905.
26. [26] van Het Hof, K.H., West, C.E., Weststrate, J.A., Hautvast, J.G., Dietary factors that affect the bioavailability of carotenoids. J Nutr 130:3 (2000), 503–506.
27. [27] Saadatian-Elahi, M., Slimani, N., Chajes, V., Jenab, M., Goudable, J., Biessy, C., et al. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 89:1 (2009), 331–346.
28. [28] Al-Delaimy, W.K., Ferrari, P., Slimani, N., Pala, V., Johansson, I., Nilsson, S., et al. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Clin Nutr 59:12 (2005), 1387–1396.
29. [29] Devore, E.E., Kang, J.H., Stampfer, M.J., Grodstein, F., The association of antioxidants and cognition in the Nurses’ Health Study. Am J Epidemiol 177:1 (2013), 33–41.
30. [30] Calder, P.C., Mechanisms of action of (n-3) fatty acids. J Nutr 142:3 (2012), 592s–599s.