Statistical optimization of controlled release microspheres containing cetirizine hydrochloride as a model for water soluble drugs

Pharmaceutical Development and Technology

Volumn 20, Issue 6, 2015, Pages 738-746

  El Say, Khalid M ^a,b   El Helw, Abdel Rahim M ^a   Ahmed, Osama A A ^a,c   Hosny, Khaled M ^a,d   Ahmed, Tarek A ^a,b   Kharshoum, Rasha M ^d   Fahmy, Usama A ^a   Alsawahli, Majed ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Al Azhar University   (Egypt)

^c Minia University   (Egypt)

^d Beni Suef University   (Egypt)

Author keywords

Box Behnken; Cetirizine HCl; Emulsion solvent evaporation; Eudragit RS100; Microspheres; Response surface methodology

Indexed keywords

CETIRIZINE; MICROSPHERE; ACRYLIC ACID RESIN; ANTIALLERGIC AGENT; DELAYED RELEASE FORMULATION; EUDRAGIT RS; HEXOSE; HISTAMINE H1 RECEPTOR ANTAGONIST; SORBITAN OLEATE; SURFACTANT; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; EMULSION SOLVENT EVAPORATION; ENCAPSULATION; EVAPORATION; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SCANNING ELECTRON MICROSCOPY; STATISTICAL ANALYSIS; TIME TO MAXIMUM PLASMA CONCENTRATION; BLOOD; CHEMISTRY; DELAYED RELEASE FORMULATION; ORAL DRUG ADMINISTRATION; SOLUBILITY; YOUNG ADULT;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ADULT; ANTI-ALLERGIC AGENTS; CETIRIZINE; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; HEXOSES; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; MALE; SOLUBILITY; SURFACE-ACTIVE AGENTS; WATER; YOUNG ADULT;

EID: 84964194113     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2014.920353     Document Type: Article

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