Increasing sodium pantoprazole photostability by microencapsulation: Effect of the polymer and the preparation technique

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 3, 2008, Pages 1014-1018

  Raffin, R P ^a   Colome L M ^a   Schapoval, E E S ^a   Pohlmann, A R ^a   Guterres, S S ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

HPLC; Microencapsulation; Pantoprazole; Photostability; Solvent evaporation; Spray drying

Indexed keywords

EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; METHANOL; METHOCEL F4 M; METHYLCELLULOSE; PANTOPRAZOLE; POLYCAPROLACTONE; POLYMER; PROTON PUMP INHIBITOR; SOLVENT; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; DRUG DEGRADATION; DRUG HALF LIFE; DRUG MANUFACTURE; DRUG STABILITY; EMULSION; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROENCAPSULATION; PARTICLE SIZE; TECHNIQUE; ULTRAVIOLET C RADIATION;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESICCATION; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; EXCIPIENTS; LIGHT; METHANOL; NANOPARTICLES; PARTICLE SIZE; PHOTOCHEMISTRY; POLYMERS; PROTON PUMP INHIBITORS; SOLUTIONS; SOLVENTS; ULTRAVIOLET RAYS;

EID: 48149091092     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.01.024     Document Type: Article

References (20)

1. Jungnickel P.W. Pantoprazole: a new proton pump inhibitor. Clin. Ther. 22 (2000) 1268-1293
2. +-ATPase. Biochim. Biophys. Acta 1148 (1993) 223-233
3. Cheer S., Prakash A., Faulds D., and Lamb H. Pantoprazole - an update of its pharmacological properties and therapeutic use in the management of acid-related disorders. Drugs 63 1 (2003) 101-132
4. Raffin R.P., Colomé L.M., Pohlmann A.R., and Guterres S.S. Preparation, characterization and in vivo anti-ulcer evaluation of pantoprazole-loaded microparticles. Eur. J. Pharm. Biopharm. 63 (2006) 198-204
5. Raffin R.P., Colomé L.M., Guterres S.S., and Pohlmann A.R. Enteric controlled release pantoprazole-loaded microparticles prepared using Eudragit S100 and poly(ε-caprolactone) blend. Pharm. Dev. Tech. (2007) 10.1080/1083745070155693
6. Raffin R.P., Guterres S.S., Pohlmann A.R., and Ré M.I. Powder characteristics of pantoprazole delivery systems produced in different spray-dryer scales. Drying Tech. 24 (2006) 339-348
7. Raffin R.P., Jornada D.S., Ré M.I., Pohlmann A.R., and Guterres S.S. Sodium Pantoprazole-loaded enteric microparticles prepared by spray drying: effect of the scale of production and process validation. Int. J. Pharm. 324 (2006) 10-18
8. ® blended microparticles containing sodium pantoprazole. Pharmazie 62 (2007) 361-364
9. Thorma K. Photodecomposition and stabilization of compounds in dosage forms. In: Tennes H.H. (Ed). Photostability of Drugs and Drug Formulations (1996), CRC Press, London, UK 111-140
10. Glass B.D., Novák C.S., and Brown M.E. The thermal and photostability of solid pharmaceuticals: a review. J. Therm. Anal. Calorim. 77 (2004) 1013-1036
11. Aman W., and Thoma K. The influence of formulation and manufacturing process on the photostability of tablets. Int. J. Pharm. 243 (2002) 33-41
12. Tursilli R., Casolari A., Iannuccelli V., and Scalia S. Enhancement of melatonin photostability by encapsulation in lipospheres. J. Pharm. Biomed. Anal. 40 (2006) 910-914
13. Iannuccelli V., Sala N., Tursilli R., Coppi G., and Scalia S. Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability. Eur. J. Pharm. Biopharm. 63 (2006) 140-145
14. El-Sherif Z.A., Mohamed A.O., El-Bardicy M.G., and El-Tarras M.F. Reversed-phase high performance liquid chromatographic method for the determination of lansoprazole, omeprazole and pantoprazole sodium sesquihydrate in presence of their acid-induced degradation products. Chem. Pharm. Bull. 54 (2006) 814-818
15. Ekpe A., and Jacobsen T. Effect of various salts on the stability of lansoprazole, omeprazole, and pantoprazole as determined by high-performance liquid chromatography. Drug Dev. Ind. Pharm. 25 (1999) 1057-1065
16. Raffin R.P., Colomé L.M., Guterres S.S., and Pohlmann A.R. Validation of analytical methodology by HPLC for quantification and stability evaluation of sodium pantoprazole. Quim. Nova 30 (2007) 1001-1005
17. DellaGreca M., Iesce M.R., Previtera L., Rubino M., Temussi F., and Brigante M. Degradation of lansoprazole and omeprazole in the aquatic environment. Chemosphere 63 (2006) 1087-1093
18. C.V. Garcia, N.S. Nudelman, M. Steppe, E.E.S. Schapoval, Structural elucidation of rabeprazole sodium photodegradation products, J. Pharm. Biomed. Anal, 2003, doi:10.1016/j.jpba.2007.09.002.
19. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), Validation of analytical procedures: methodology, 1996.
20. Scalia S., Tursilli R., Sala N., and Iannuccelli V. Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-β-cyclodextrin. Int. J. Pharm. 320 (2006) 79-85