메뉴 건너뛰기




Volumn 127, Issue 5, 2015, Pages 494-502

Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones

Author keywords

Bariatric surgery; Drugs; Gut hormones; Lifestyle management; Obesity

Indexed keywords

AGOUTI RELATED PROTEIN; ALBIGLUTIDE; AMFEBUTAMONE PLUS NALTREXONE; DIPEPTIDYL PEPTIDASE IV; DULAGLUTIDE; EXENDIN 4; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 21; GLUCAGON LIKE PEPTIDE 1; LIRAGLUTIDE; LIXISENATIDE; MELANOCORTIN; NEUROPEPTIDE; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; PHENTERMINE; RIMONABANT; SIBUTRAMINE; TETRAHYDROLIPSTATIN; ANTIOBESITY AGENT; GASTROINTESTINAL HORMONE;

EID: 84964053766     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.1080/00325481.2015.1048181     Document Type: Review
Times cited : (13)

References (122)
  • 1
    • 84964080573 scopus 로고    scopus 로고
    • WHO. Report of the advisory committee on health research. Geneva: Genomics and World Health
    • WHO. Report of the advisory committee on health research. Geneva: Genomics and World Health; 2002.
    • (2002)
  • 2
    • 33750700056 scopus 로고    scopus 로고
    • Preventing chronic diseases
    • A Vital investment: WHO global report. World Health Organization, Geneva; 2005, Available from
    • Tunstall- Pedoe H, Tunstall-Pedoe H. Preventing chronic diseases. A Vital investment: WHO global report. World Health Organization, Geneva; 2005. pp 200. Available from http://www.who.int/chp/chronic_disease_report/en/. Int J Epidemiol 2006;35(4):1107.
    • (2006) Int J Epidemiol , vol.35 , Issue.4 , pp. 200-1107
    • Tunstall- Pedoe, H.1    Tunstall-Pedoe, H.2
  • 4
    • 84964079722 scopus 로고    scopus 로고
    • Children’s BMI, overweight and obesity
    • Bridges ST. Children’s BMI, overweight and obesity. Health Survey Engl 2010.
    • (2010) Health Survey Engl
    • Bridges, S.T.1
  • 5
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    • Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012;307:491–7.
    • (2012) JAMA , vol.307 , pp. 491-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3    Ogden, C.L.4
  • 6
    • 84856433589 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012;307:483–90.
    • (2012) JAMA , vol.307 , pp. 483-490
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 7
    • 84893026260 scopus 로고    scopus 로고
    • Interdisciplinary European guidelines on metabolic and bariatric surgery
    • Fried M, Yumuk V, Oppert JM, Scopinaro N, Torres A, Weiner R, et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. Obes Surg 2014;24:42–55.
    • (2014) Obes Surg , vol.24 , pp. 42-55
    • Fried, M.1    Yumuk, V.2    Oppert, J.M.3    Scopinaro, N.4    Torres, A.5    Weiner, R.6
  • 9
    • 84896695547 scopus 로고    scopus 로고
    • Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study
    • Johansson K, Sundström J, Marcus C, Hemmingsson E, Neovius M. Risk of symptomatic gallstones and cholecystectomy after a very-low-calorie diet or low-calorie diet in a commercial weight loss program: 1-year matched cohort study. Int J Obesity 2014;38:279–84.
    • (2014) Int J Obesity , vol.38 , pp. 279-284
    • Johansson, K.1    Sundström, J.2    Marcus, C.3    Hemmingsson, E.4    Neovius, M.5
  • 10
    • 33750598236 scopus 로고    scopus 로고
    • The evolution of very-low-calorie diets: An update and meta-analysis
    • Tsai AG, Wadden TA. The evolution of very-low-calorie diets: an update and meta-analysis. Obesity 2006;14:1283–93.
    • (2006) Obesity , vol.14 , pp. 1283-1293
    • Tsai, A.G.1    Wadden, T.A.2
  • 11
    • 4344696761 scopus 로고    scopus 로고
    • What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials
    • Avenell A, Brown TJ, McGee MA, Campbell MK, Grant AM, Broom J, et al. What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials. J Human Nutr Diet 2004;17:317–35.
    • (2004) J Human Nutr Diet , vol.17 , pp. 317-335
    • Avenell, A.1    Brown, T.J.2    McGee, M.A.3    Campbell, M.K.4    Grant, A.M.5    Broom, J.6
  • 12
    • 33845780591 scopus 로고    scopus 로고
    • Popular weight-loss diets: From evidence to practice
    • Malik VS, Hu FB. Popular weight-loss diets: from evidence to practice. Nat Clin Pract Cardiov Med 2007;4:34–41.
    • (2007) Nat Clin Pract Cardiov Med , vol.4 , pp. 34-41
    • Malik, V.S.1    Hu, F.B.2
  • 14
    • 61449183682 scopus 로고    scopus 로고
    • Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    • Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Eng J Med 2009;360:859–73.
    • (2009) N Eng J Med , vol.360 , pp. 859-873
    • Sacks, F.M.1    Bray, G.A.2    Carey, V.J.3    Smith, S.R.4    Ryan, D.H.5    Anton, S.D.6
  • 15
    • 84907339499 scopus 로고    scopus 로고
    • Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults
    • Johnston BC, Kanters S, Bandayrel K, Wu P, Naji F, Siemieniuk RA, et al. Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults. JAMA 2014;312:923.
    • (2014) JAMA , vol.312 , pp. 923
    • Johnston, B.C.1    Kanters, S.2    Bandayrel, K.3    Wu, P.4    Naji, F.5    Siemieniuk, R.A.6
  • 16
    • 79960969194 scopus 로고    scopus 로고
    • Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes
    • Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 2011;34:1481–6.
    • (2011) Diabetes Care , vol.34 , pp. 1481-1486
    • Wing, R.R.1    Lang, W.2    Wadden, T.A.3    Safford, M.4    Knowler, W.C.5    Bertoni, A.G.6
  • 17
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011;54:2506–14.
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1    Hollingsworth, K.G.2    Aribisala, B.S.3    Chen, M.J.4    Mathers, J.C.5    Taylor, R.6
  • 18
    • 84861706656 scopus 로고    scopus 로고
    • Micronutrient deficiency in obese subjects undergoing low calorie diet
    • Damms-Machado A, Weser G, Bischoff SC. Micronutrient deficiency in obese subjects undergoing low calorie diet. Nutr J 2012;11:34.
    • (2012) Nutr J , vol.11 , pp. 34
    • Damms-Machado, A.1    Weser, G.2    Bischoff, S.C.3
  • 19
    • 30544437731 scopus 로고    scopus 로고
    • Long-term weight loss after diet and exercise: A systematic review
    • Curioni CC, Lourenco PM. Long-term weight loss after diet and exercise: a systematic review. Int J Obesity 2005;29:1168–74.
    • (2005) Int J Obesity , vol.29 , pp. 1168-1174
    • Curioni, C.C.1    Lourenco, P.M.2
  • 20
    • 30544443423 scopus 로고    scopus 로고
    • Systematic review of long-term weight loss studies in obese adults: Clinical significance and applicability to clinical practice
    • Douketis JD, Macie C, Thabane L, Williamson DF. Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice. Int J Obesity 2005;29:1153–67.
    • (2005) Int J Obesity , vol.29 , pp. 1153-1167
    • Douketis, J.D.1    Macie, C.2    Thabane, L.3    Williamson, D.F.4
  • 21
    • 11244331742 scopus 로고    scopus 로고
    • Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: A randomized trial
    • Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005;293:43–53.
    • (2005) JAMA , vol.293 , pp. 43-53
    • Dansinger, M.L.1    Gleason, J.A.2    Griffith, J.L.3    Selker, H.P.4    Schaefer, E.J.5
  • 22
    • 4243120018 scopus 로고
    • Human starvation and its consequences
    • Keys A. Human starvation and its consequences. J Am Diet Assoc 1946;22:582–7.
    • (1946) J am Diet Assoc , vol.22 , pp. 582-587
    • Keys, A.1
  • 26
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Eng J Med 1995;332:621–8.
    • (1995) N Eng J Med , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 27
    • 84876920263 scopus 로고    scopus 로고
    • Weight loss, weight maintenance, and adaptive thermogenesis 1-3
    • Camps SG, Verhoef SP, Westerterp KR. Weight loss, weight maintenance, and adaptive thermogenesis 1-3. Am J Clin Nutr 2013;97:990–5.
    • (2013) Am J Clin Nutr , vol.97 , pp. 990-995
    • Camps, S.G.1    Verhoef, S.P.2    Westerterp, K.R.3
  • 28
    • 84882967018 scopus 로고    scopus 로고
    • Biological mechanisms that promote weight regain following weight loss in obese humans
    • Ochner CN, Barrios DM, Lee CD, Pi-Sunyer FX. Biological mechanisms that promote weight regain following weight loss in obese humans. Physiol Behav 2013;120:106–13.
    • (2013) Physiol Behav , vol.120 , pp. 106-113
    • Ochner, C.N.1    Barrios, D.M.2    Lee, C.D.3    Pi-Sunyer, F.X.4
  • 29
    • 46749099010 scopus 로고    scopus 로고
    • Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    • Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Investig 2008; 118:2583–91.
    • (2008) J Clin Investig , vol.118 , pp. 2583-2591
    • Rosenbaum, M.1    Sy, M.2    Pavlovich, K.3    Leibel, R.L.4    Hirsch, J.5
  • 30
    • 84875288613 scopus 로고    scopus 로고
    • Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans
    • Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of reduced weight maintenance and leptin repletion on functional connectivity of the hypothalamus in obese humans. PLoS One 2013;8:e59114.
    • (2013) Plos One , vol.8
    • Hinkle, W.1    Cordell, M.2    Leibel, R.3    Rosenbaum, M.4    Hirsch, J.5
  • 31
    • 34250791554 scopus 로고    scopus 로고
    • The role of physical activity in producing and maintaining weight loss
    • Catenacci VA, Wyatt HR. The role of physical activity in producing and maintaining weight loss. Nat Clin Pract Endocrinol Metabol 2007;3:518–29.
    • (2007) Nat Clin Pract Endocrinol Metabol , vol.3 , pp. 518-529
    • Catenacci, V.A.1    Wyatt, H.R.2
  • 32
    • 34147176453 scopus 로고    scopus 로고
    • Long-term weight losses associated with prescription of higher physical activity goals. Are higher levels of physical activity protective against weight regain?
    • Tate DF, Jeffery RW, Sherwood NE, Wing RR. Long-term weight losses associated with prescription of higher physical activity goals. Are higher levels of physical activity protective against weight regain? Am J Clin Nutr 2007;85:954–9.
    • (2007) Am J Clin Nutr , vol.85 , pp. 954-959
    • Tate, D.F.1    Jeffery, R.W.2    Sherwood, N.E.3    Wing, R.R.4
  • 33
    • 84930707521 scopus 로고    scopus 로고
    • Obesity: Identification, assessment and management of overweight and obesity in children, young people and adults 1-recommendations Guidance and guidelines
    • NICE guidelines [CG189]
    • NICE guidelines [CG189]. Obesity: identification, assessment and management of overweight and obesity in children, young people and adults 1-recommendations Guidance and guidelines. 2014.
    • (2014)
  • 34
    • 84964070900 scopus 로고    scopus 로고
    • Physical Activity Guidelines for Americans, Available from
    • Physical Activity Guidelines for Americans. 2008. Available from: http://www.health.gov/paguidelines/guidelines/chapter4. aspx.
    • (2008)
  • 35
  • 36
    • 84903212216 scopus 로고    scopus 로고
    • AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American college of cardiology/American heart association task force on practice guidelines and the obesity society
    • Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American college of cardiology/American heart association task force on practice guidelines and the obesity society. J Am Coll Cardiol 2014;63:2985–3023.
    • (2013) J am Coll Cardiol , vol.63 , pp. 2985-3023
    • Jensen, M.D.1    Ryan, D.H.2    Apovian, C.M.3    Ard, J.D.4    Comuzzie, A.G.5    Donato, K.A.6
  • 37
    • 0025151747 scopus 로고
    • Maintenance and relapse after weight loss in women: Behavioral aspects
    • Kayman S, Bruvold W, Stern JS. Maintenance and relapse after weight loss in women: behavioral aspects. Am J Clin Nutr 1990;52:800–7.
    • (1990) Am J Clin Nutr , vol.52 , pp. 800-807
    • Kayman, S.1    Bruvold, W.2    Stern, J.S.3
  • 38
    • 84964000125 scopus 로고    scopus 로고
    • WHO. Obesity: preventing and managing the global epidemic. Report of WHO Consultation on Obesity. WHO Technical. World Health Organization, Geneva; 2000. Available from
    • WHO. Obesity: preventing and managing the global epidemic. Report of WHO Consultation on Obesity. WHO Technical. World Health Organization, Geneva; 2000. Available from http://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/.
  • 39
    • 0026353971 scopus 로고
    • Gastrointestinal surgery for severe obesity. Consensus development conference panel
    • NIH conference
    • NIH conference. Gastrointestinal surgery for severe obesity. consensus development conference panel. Ann Int Med 1991;115:956–61.
    • (1991) Ann Int Med , vol.115 , pp. 956-961
  • 40
    • 84897990965 scopus 로고    scopus 로고
    • Bariatric surgery in class I obesity: A position statement from the international federation for the surgery of obesity and metabolic disorders (IFSO)
    • Busetto L, Dixon J, De Luca M, Shikora S, Pories W, Angrisani L. Bariatric surgery in class I obesity: a position statement from the international federation for the surgery of obesity and metabolic disorders (IFSO). Obes Surg 2014;24:487–519.
    • (2014) Obes Surg , vol.24 , pp. 487-519
    • Busetto, L.1    Dixon, J.2    De Luca, M.3    Shikora, S.4    Pories, W.5    Angrisani, L.6
  • 42
    • 1642545691 scopus 로고    scopus 로고
    • Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery
    • discussion 54–5
    • Slater GH, Ren CJ, Siegel N, Williams T, Barr D, Wolfe B, et al. Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery. J Gastroint Surg 2004;8:48–55; discussion 54–5.
    • (2004) J Gastroint Surg , vol.8 , pp. 48-55
    • Slater, G.H.1    Ren, C.J.2    Siegel, N.3    Williams, T.4    Barr, D.5    Wolfe, B.6
  • 43
    • 67649846467 scopus 로고    scopus 로고
    • Vitamin status after bariatric surgery: A randomized study of gastric bypass and duodenal switch 1 – 3
    • Aasheim ET, Bjo S, Hanvold SE, Engström M, Hanvold SE, Mala T, et al. Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch 1 – 3. Am J Clin Nutr 2009;90:15–22.
    • (2009) Am J Clin Nutr , vol.90 , pp. 15-22
    • Aasheim, E.T.1    Bjo, S.2    Hanvold, S.E.3    Engström, M.4    Hanvold, S.E.5    Mala, T.6
  • 44
    • 61549094077 scopus 로고    scopus 로고
    • Weight and type 2 diabetes after bariatric surgery: Systematic review and meta-analysis
    • Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009;122:248–56.
    • (2009) Am J Med , vol.122 , pp. 248-256
    • Buchwald, H.1    Estok, R.2    Fahrbach, K.3    Banel, D.4    Jensen, M.D.5    Pories, W.J.6
  • 45
    • 82955195922 scopus 로고    scopus 로고
    • Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders
    • Pournaras DJ, Aasheim ET, Søvik TT, Andrews R, Mahon D, Welbourn R, et al. Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders. Br J Surg 2012;99:100–3.
    • (2012) Br J Surg , vol.99 , pp. 100-103
    • Pournaras, D.J.1    Aasheim, E.T.2    Søvik, T.T.3    Andrews, R.4    Mahon, D.5    Welbourn, R.6
  • 47
    • 84873990663 scopus 로고    scopus 로고
    • Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery
    • Sjöström L. Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Int Med 2013;273:219–34.
    • (2013) J Int Med , vol.273 , pp. 219-234
    • Sjöström, L.1
  • 48
    • 84885024022 scopus 로고    scopus 로고
    • Laparoscopic sleeve gastrectomy compared with other bariatric surgical procedures: A systematic review of randomized trials
    • Trastulli S, Desiderio J, Guarino S, Frampton GK. Laparoscopic sleeve gastrectomy compared with other bariatric surgical procedures: a systematic review of randomized trials. Surgery Obesity Related Dis 2013;9:816–29.
    • (2013) Surgery Obesity Related Dis , vol.9 , pp. 816-829
    • Trastulli, S.1    Desiderio, J.2    Guarino, S.3    Frampton, G.K.4
  • 49
    • 84925581325 scopus 로고    scopus 로고
    • Laparoscopic Roux-en-Y gastric bypass versus sleeve gastrectomy for obese patients with Type 2 diabetes: A meta-analysis of randomized controlled trials
    • Wang MC, Guo XH, Zhang YW, Zhang YL, Zhang HH, Zhang YC. Laparoscopic Roux-en-Y gastric bypass versus sleeve gastrectomy for obese patients with Type 2 diabetes: a meta-analysis of randomized controlled trials. Am Surg 2015;81:166–71.
    • (2015) Am Surg , vol.81 , pp. 166-171
    • Wang, M.C.1    Guo, X.H.2    Zhang, Y.W.3    Zhang, Y.L.4    Zhang, H.H.5    Zhang, Y.C.6
  • 55
    • 32944470975 scopus 로고    scopus 로고
    • Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety
    • Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG, Aylwin SJ. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg 2006;93:210–15.
    • (2006) Br J Surg , vol.93 , pp. 210-215
    • Borg, C.M.1    Le Roux, C.W.2    Ghatei, M.A.3    Bloom, S.R.4    Patel, A.G.5    Aylwin, S.J.6
  • 56
    • 35649021752 scopus 로고    scopus 로고
    • Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass
    • Le Roux CW, Welbourn R, Werling M, Osborne A, Kokkinos A, Laurenius A, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007;246:780–5.
    • (2007) Ann Surg , vol.246 , pp. 780-785
    • Le Roux, C.W.1    Welbourn, R.2    Werling, M.3    Osborne, A.4    Kokkinos, A.5    Laurenius, A.6
  • 57
    • 30144444692 scopus 로고    scopus 로고
    • Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    • Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006;243:108–14.
    • (2006) Ann Surg , vol.243 , pp. 108-114
    • Roux, C.W.1    Aylwin, S.J.2    Batterham, R.L.3    Borg, C.M.4    Coyle, F.5    Prasad, V.6
  • 58
    • 0031874016 scopus 로고    scopus 로고
    • Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity
    • Näslund E, Backman L, Holst JJ, Theodorsson E, Hellström PM. Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity. Obesity Surg 1998;8:253–60.
    • (1998) Obesity Surg , vol.8 , pp. 253-260
    • Näslund, E.1    Backman, L.2    Holst, J.J.3    Theodorsson, E.4    Hellström, P.M.5
  • 63
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • Wynne K, Park AJ, Small CJ, Meeran K, Ghatei MA, Frost GS, Bloom SR. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial. Int J Obesity 2006;30:1729–36.
    • (2006) Int J Obesity , vol.30 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6    Bloom, S.R.7
  • 64
    • 84858294193 scopus 로고    scopus 로고
    • Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass
    • Fenske WK, Bueter M, Miras a D, Ghatei MA, Bloom SR, le Roux CW. Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass. Int J Obesity 2012;36: 379–84.
    • (2012) Int J Obesity , vol.36 , pp. 379-384
    • Fenske, W.K.1    Bueter, M.2    Miras A, D.3    Ghatei, M.A.4    Bloom, S.R.5    Le Roux, C.W.6
  • 65
    • 79960088798 scopus 로고    scopus 로고
    • Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: Role of gut peptides
    • Falkén Y, Hellström PM, Holst JJ, Näslund E. Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: Role of gut peptides. J Clin Endoc Metab 2011;96:2227–35.
    • (2011) J Clin Endoc Metab , vol.96 , pp. 2227-2235
    • Falkén, Y.1    Hellström, P.M.2    Holst, J.J.3    Näslund, E.4
  • 66
    • 84887830930 scopus 로고    scopus 로고
    • Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass
    • Dirksen C, Jørgensen NB, Bojsen-Møller KN, Kielgast U, Jacobsen SH, Clausen TR, et al. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int J Obesity 2013;37:1452–9.
    • (2013) Int J Obesity , vol.37 , pp. 1452-1459
    • Dirksen, C.1    Jørgensen, N.B.2    Bojsen-Møller, K.N.3    Kielgast, U.4    Jacobsen, S.H.5    Clausen, T.R.6
  • 67
    • 84885469835 scopus 로고    scopus 로고
    • GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery
    • Jime_nez A, Casamitjana R, Viaplana-Masclans J, Lacy A, Vidal J. GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery. Diabetes Care 2013;36:2062–9.
    • (2013) Diabetes Care , vol.36 , pp. 2062-2069
    • Jime_Nez, A.1    Casamitjana, R.2    Viaplana-Masclans, J.3    Lacy, A.4    Vidal, J.5
  • 68
    • 84895794702 scopus 로고    scopus 로고
    • Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency
    • Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Mol Metab 2014;3:191–201.
    • (2014) Mol Metab , vol.3 , pp. 191-201
    • Mokadem, M.1    Zechner, J.F.2    Margolskee, R.F.3    Drucker, D.J.4    Aguirre, V.5
  • 70
    • 84868293826 scopus 로고    scopus 로고
    • The gut endocrine system as a coordinator of postprandial nutrient homoeostasis
    • Gribble FM. The gut endocrine system as a coordinator of postprandial nutrient homoeostasis. Proc Nutr Soc 2012;71:456–62.
    • (2012) Proc Nutr Soc , vol.71 , pp. 456-462
    • Gribble, F.M.1
  • 71
    • 84939894575 scopus 로고    scopus 로고
    • Vagal innervation of intestine contributes to weight loss After Roux-en-Y gastric bypass surgery in rats
    • Hao Z, Townsend RL, Mumphrey MB, Patterson LM, Ye J, Berthoud HR. Vagal innervation of intestine contributes to weight loss After Roux-en-Y gastric bypass surgery in rats. Obesity Surg 2014;24:2145–51.
    • (2014) Obesity Surg , vol.24 , pp. 2145-2151
    • Hao, Z.1    Townsend, R.L.2    Mumphrey, M.B.3    Patterson, L.M.4    Ye, J.5    Berthoud, H.R.6
  • 72
    • 84892609615 scopus 로고    scopus 로고
    • Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse
    • Gautron L, Zechner JF, Aguirre V. Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse. Int J Obesity 2013;37:1603–7.
    • (2013) Int J Obesity , vol.37 , pp. 1603-1607
    • Gautron, L.1    Zechner, J.F.2    Aguirre, V.3
  • 75
    • 84862661746 scopus 로고    scopus 로고
    • Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: A randomized, prospective trial
    • Peterli R, Steinert RE, Woelnerhanssen B, Peters T, Christoffel-Courtin C, Gass M, et al. Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obesity Surg 2012;22:740–8.
    • (2012) Obesity Surg , vol.22 , pp. 740-748
    • Peterli, R.1    Steinert, R.E.2    Woelnerhanssen, B.3    Peters, T.4    Christoffel-Courtin, C.5    Gass, M.6
  • 77
    • 80051545971 scopus 로고    scopus 로고
    • Metabolic surgery profoundly influences gut microbialhost metabolic cross-talk
    • Li JV, Ashrafian H, Bueter M, Kinross J, Sands C, le Roux CW, et al. Metabolic surgery profoundly influences gut microbialhost metabolic cross-talk. Gut 2011;60:1214–23.
    • (2011) Gut , vol.60 , pp. 1214-1223
    • Li, J.V.1    Ashrafian, H.2    Bueter, M.3    Kinross, J.4    Sands, C.5    Le Roux, C.W.6
  • 79
    • 84910003335 scopus 로고    scopus 로고
    • Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature
    • Sweeney TE, Morton JM. Metabolic surgery: action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature. Best Pract Res Clin Gastroenterol 2014;28:727–40.
    • (2014) Best Pract Res Clin Gastroenterol , vol.28 , pp. 727-740
    • Sweeney, T.E.1    Morton, J.M.2
  • 80
    • 47549094687 scopus 로고    scopus 로고
    • Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes
    • Laferrère B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A, et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 2008;93:2479–85.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2479-2485
    • Laferrère, B.1    Teixeira, J.2    McGinty, J.3    Tran, H.4    Egger, J.R.5    Colarusso, A.6
  • 81
    • 67650417904 scopus 로고    scopus 로고
    • Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass
    • Korner J, Inabnet W, Febres G, Conwell IM, McMahon DJ, Salas R, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass. Int J Obesity 2009;33:786–95.
    • (2009) Int J Obesity , vol.33 , pp. 786-795
    • Korner, J.1    Inabnet, W.2    Febres, G.3    Conwell, I.M.4    McMahon, D.J.5    Salas, R.6
  • 82
    • 33750332212 scopus 로고    scopus 로고
    • Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: A randomized clinical trial
    • Olbers T, Björkman S, Lindroos A, Maleckas A, Lönn L, Sjöström L, Lönroth H. Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial. Ann Surg 2006;244:715–22.
    • (2006) Ann Surg , vol.244 , pp. 715-722
    • Olbers, T.1    Björkman, S.2    Lindroos, A.3    Maleckas, A.4    Lönn, L.5    Sjöström, L.6    Lönroth, H.7
  • 83
    • 84895077083 scopus 로고    scopus 로고
    • Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding
    • Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, et al. Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding. Gut 2014;63:891–902.
    • (2014) Gut , vol.63 , pp. 891-902
    • Scholtz, S.1    Miras, A.D.2    Chhina, N.3    Prechtl, C.G.4    Sleeth, M.L.5    Daud, N.M.6
  • 84
    • 35348831042 scopus 로고    scopus 로고
    • Trends in mortality in bariatric surgery: A systematic review and metaanalysis
    • Buchwald H, Estok R, Fahrbach K, Banel D, Sledge I. Trends in mortality in bariatric surgery: a systematic review and metaanalysis. Surgery 2007;142:621–32.
    • (2007) Surgery , vol.142 , pp. 621-632
    • Buchwald, H.1    Estok, R.2    Fahrbach, K.3    Banel, D.4    Sledge, I.5
  • 85
    • 79955968112 scopus 로고    scopus 로고
    • Bariatric surgery: An IDF statement for obese Type 2 diabetes
    • Dixon JB, Zimmet P, Alberti KG, Rubino F. Bariatric surgery: an IDF statement for obese Type 2 diabetes. Diabetic Med 2011;28:628–42.
    • (2011) Diabetic Med , vol.28 , pp. 628-642
    • Dixon, J.B.1    Zimmet, P.2    Alberti, K.G.3    Rubino, F.4
  • 87
    • 84942594368 scopus 로고    scopus 로고
    • Eligibility for bariatric surgery among adults in England: Analysis of a national cross-sectional survey
    • 2042533313512479
    • Ahmad A, Laverty AA, Aasheim E, Majeed A, Millett C, Saxena S. Eligibility for bariatric surgery among adults in England: analysis of a national cross-sectional survey. JRSM open 2014;5:2042533313512479.
    • (2014) JRSM Open , vol.5
    • Ahmad, A.1    Laverty, A.A.2    Aasheim, E.3    Majeed, A.4    Millett, C.5    Saxena, S.6
  • 88
    • 84999279186 scopus 로고    scopus 로고
    • Draft Guideline on clinical evaluation of medicinal products used in weight control
    • European Medicines Agency, Available from
    • European Medicines Agency. Draft Guideline on clinical evaluation of medicinal products used in weight control. 2014. Available from http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2014/07/WC500170278.pdf.
    • (2014)
  • 89
    • 84860330219 scopus 로고    scopus 로고
    • Food and drug administration’s obesity drug guidance document: A short history
    • Colman E. Food and drug administration’s obesity drug guidance document: a short history. Circulation 2012;125:2156–64.
    • (2012) Circulation , vol.125 , pp. 2156-2164
    • Colman, E.1
  • 93
    • 1042303480 scopus 로고    scopus 로고
    • XENical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    • Torgerson JS, Hauptman J, Boldrin MN, Sjöström L. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004;27:155–61.
    • (2004) Diabetes Care , vol.27 , pp. 155-161
    • Torgerson, J.S.1    Hauptman, J.2    Boldrin, M.N.3    Sjöström, L.4
  • 96
    • 79954561234 scopus 로고    scopus 로고
    • Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): A randomised, placebo-controlled, phase 3 trial
    • Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, Day WW. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet 2011;377:1341–52.
    • (2011) Lancet , vol.377 , pp. 1341-1352
    • Gadde, K.M.1    Allison, D.B.2    Ryan, D.H.3    Peterson, C.A.4    Troupin, B.5    Schwiers, M.L.6    Day, W.W.7
  • 97
    • 84964010519 scopus 로고    scopus 로고
    • Press Announcements. FDA approves weight-management drug Saxenda [Internet]
    • Press Announcements. FDA approves weight-management drug Saxenda [Internet]. 2015. Available from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427913.htm.
    • (2015)
  • 98
    • 84964010530 scopus 로고    scopus 로고
    • Press Announcements. FDA approves weight-management drug Contrave [Internet], Available from
    • Press Announcements. FDA approves weight-management drug Contrave [Internet]. 2014. Available from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm413896.htm.
    • (2014)
  • 99
    • 84964086972 scopus 로고    scopus 로고
    • European Medicines Agency. News and Events - Saxenda recommended for approval in weight management in adults [Internet], Available from
    • European Medicines Agency. News and Events - Saxenda recommended for approval in weight management in adults [Internet]. 2015. Available from http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2015/01/news_detail_002255.jsp&mid=WC0b01ac058004d5c1.
    • (2015)
  • 100
    • 79958282647 scopus 로고    scopus 로고
    • Naltrexone SR/Bupropion SR (Contrave): A new approach to weight loss in obese adults
    • P T
    • Ornellas T, Chavez B. Naltrexone SR/Bupropion SR (Contrave): A new approach to weight loss in obese adults. P T 2011;36:255–62.
    • (2011) , vol.36 , pp. 255-262
    • Ornellas, T.1    Chavez, B.2
  • 101
    • 77956057548 scopus 로고    scopus 로고
    • Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (CORI): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
    • Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (CORI): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2010;376:595–605.
    • (2010) Lancet , vol.376 , pp. 595-605
    • Greenway, F.L.1    Fujioka, K.2    Plodkowski, R.A.3    Mudaliar, S.4    Guttadauria, M.5    Erickson, J.6
  • 102
    • 84879324574 scopus 로고    scopus 로고
    • A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II)
    • Apovian CM, Aronne L, Rubino D, Still C, Wyatt H, Burns C, et al. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity 2013;21:935–43.
    • (2013) Obesity , vol.21 , pp. 935-943
    • Apovian, C.M.1    Aronne, L.2    Rubino, D.3    Still, C.4    Wyatt, H.5    Burns, C.6
  • 103
    • 84891869792 scopus 로고    scopus 로고
    • Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type2 diabetes
    • Hollander P, Gupta AK, Plodkowski R, Greenway F, Bays H, Burns C, et al. Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type2 diabetes. Diabetes Care 2013;36:4022–9.
    • (2013) Diabetes Care , vol.36 , pp. 4022-4029
    • Hollander, P.1    Gupta, A.K.2    Plodkowski, R.3    Greenway, F.4    Bays, H.5    Burns, C.6
  • 104
    • 0032940582 scopus 로고    scopus 로고
    • Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat
    • Meeran K, O’Shea D, Edwards CM, Turton MD, Heath MM, Gunn I, et al. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat. Endocrinology 1999;140:244–50.
    • (1999) Endocrinology , vol.140 , pp. 244-250
    • Meeran, K.1    O’Shea, D.2    Edwards, C.M.3    Turton, M.D.4    Heath, M.M.5    Gunn, I.6
  • 105
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O’Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69–72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O’Shea, D.2    Gunn, I.3    Beak, S.A.4    Edwards, C.M.5    Meeran, K.6
  • 106
    • 84885669915 scopus 로고    scopus 로고
    • Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala
    • Parker JA, McCullough KA, Field BC, Minnion JS, Martin NM, Ghatei MA, Bloom SR. Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala. Int J Obesity 2013;37:1391–8.
    • (2013) Int J Obesity , vol.37 , pp. 1391-1398
    • Parker, J.A.1    McCullough, K.A.2    Field, B.C.3    Minnion, J.S.4    Martin, N.M.5    Ghatei, M.A.6    Bloom, S.R.7
  • 107
    • 84922790807 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: A review of head-to-head clinical studies
    • Trujillo JM, Nuffer W, Ellis SL. GLP-1 receptor agonists: a review of head-to-head clinical studies. Ther Adv Endocrinol Metab 2015;6:19–28.
    • (2015) Ther Adv Endocrinol Metab , vol.6 , pp. 19-28
    • Trujillo, J.M.1    Nuffer, W.2    Ellis, S.L.3
  • 108
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374:39–47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6
  • 109
    • 84887840117 scopus 로고    scopus 로고
    • Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study
    • Wadden TA, Hollander P, Klein S, Niswender K, Woo V, Hale PM, et al. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Int J Obesity 2013;37:1443–51.
    • (2013) Int J Obesity , vol.37 , pp. 1443-1451
    • Wadden, T.A.1    Hollander, P.2    Klein, S.3    Niswender, K.4    Woo, V.5    Hale, P.M.6
  • 110
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • Astrup A, Rössner S, Van Gaal L, Rissanen A, Niskanen L, Al Hakim M, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009;374:1606–16.
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rössner, S.2    Van Gaal, L.3    Rissanen, A.4    Niskanen, L.5    Al Hakim, M.6
  • 111
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    • Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME, et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obesity 2012;36:843–54.
    • (2012) Int J Obesity , vol.36 , pp. 843-854
    • Astrup, A.1    Carraro, R.2    Finer, N.3    Harper, A.4    Kunesova, M.5    Lean, M.E.6
  • 112
    • 33748471110 scopus 로고    scopus 로고
    • Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin- treated patients with type 2 diabetes mellitus
    • Ratner RE, Maggs D, Nielsen LL, Stonehouse AH, Poon T, Zhang B, et al. Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin- treated patients with type 2 diabetes mellitus. Diabetes 2006;8:419–28.
    • (2006) Diabetes , vol.8 , pp. 419-428
    • Ratner, R.E.1    Maggs, D.2    Nielsen, L.L.3    Stonehouse, A.H.4    Poon, T.5    Zhang, B.6
  • 113
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko A V, Gier B, Elashoff R, Butler PC. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011;141:150–6.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 114
    • 84879231610 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretinbased therapies: The benefits by far outweigh the potential risks
    • Nauck MA. A critical analysis of the clinical use of incretinbased therapies: The benefits by far outweigh the potential risks. Diabetes Care 2013;36:2126–32.
    • (2013) Diabetes Care , vol.36 , pp. 2126-2132
    • Nauck, M.A.1
  • 115
    • 84891821223 scopus 로고    scopus 로고
    • Do GLP-1-based therapies increase cancer risk?
    • Nauck MA, Friedrich N. Do GLP-1-based therapies increase cancer risk? Diabetes Care 2013;36:S245–52.
    • (2013) Diabetes Care , vol.36 , pp. 245-252
    • Nauck, M.A.1    Friedrich, N.2
  • 116
    • 0037847510 scopus 로고    scopus 로고
    • Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
    • Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, et al. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology 2003;124:1325–36.
    • (2003) Gastroenterology , vol.124 , pp. 1325-1336
    • Asakawa, A.1    Inui, A.2    Yuzuriha, H.3    Ueno, N.4    Katsuura, G.5    Fujimiya, M.6
  • 118
  • 120
    • 84875409178 scopus 로고    scopus 로고
    • Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
    • Tan TM, Field BCT, McCullough KA, Troke RC, Chambers ES, Salem V, et al. Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia. Diabetes 2013;62:1131–8.
    • (2013) Diabetes , vol.62 , pp. 1131-1138
    • Tan, T.M.1    Field, B.2    McCullough, K.A.3    Troke, R.C.4    Chambers, E.S.5    Salem, V.6
  • 122
    • 84921442644 scopus 로고    scopus 로고
    • Peptide therapeutics: Current status and future directions
    • Fosgerau K, Hoffmann T. Peptide therapeutics: Current status and future directions. Drug Discov Today 2015;20:122–8.
    • (2015) Drug Discov Today , vol.20 , pp. 122-128
    • Fosgerau, K.1    Hoffmann, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.