Bioengineering Lungs for Transplantation

Thoracic Surgery Clinics

Volumn 26, Issue 2, 2016, Pages 163-171

  Gilpin, Sarah E ^a,b   Charest, Jonathan M ^a   Ren, Xi ^a,b   Ott, Harald C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Bioartificial lung; Endothelium; Epithelium; Lung regeneration; Organ culture; Tissue engineering

Indexed keywords

BIOARTIFICIAL LUNG; BIOARTIFICIAL ORGAN; BIOENGINEERING; BIOREACTOR; BIOREACTOR DESIGN; CELL COUNT; DECELLULARIZED NATIVE EXTRACELLULAR MATRIX; EX VIVO STUDY; EXTRACELLULAR MATRIX; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG ENDOTHELIUM; LUNG REGENERATION; LUNG TRANSPLANTATION; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; REVIEW; TISSUE REGENERATION; PROCEDURES; TISSUE ENGINEERING; TISSUE SCAFFOLD;

BIOENGINEERING; HUMANS; LUNG TRANSPLANTATION; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84963956665     PISSN: None     EISSN: 15585069     Source Type: Journal    
DOI: 10.1016/j.thorsurg.2015.12.004     Document Type: Review

References (70)

1. McCurry K.R., Shearon T.H., Edwards L.B., et al. Lung transplantation in the United States, 1998-2007. Am J Transplant 2009, 9(4 Pt 2):942-958.
2. Renteria E., Jha P., Forman D., et al. The impact of cigarette smoking on life expectancy between 1980 and 2010: a global perspective. Tob Control 2015, [Epub ahead of print].
3. Christie J.D., Edwards L.B., Aurora P., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart/lung transplantation report-2008. J Heart Lung Transplant 2008, 27(9):957-969.
4. Hornby K., Ross H., Keshavjee S., et al. Non-utilization of hearts and lungs after consent for donation: a Canadian multicentre study. Can J Anaesth 2006, 53(8):831-837.
5. Cypel M., Keshavjee S. Extending the donor pool: rehabilitation of poor organs. Thorac Surg Clin 2015, 25(1):27-33.
6. Machuca T.N., Cypel M. Ex vivo lung perfusion. J Thorac Dis 2014, 6(8):1054-1062.
7. Weigt S.S., DerHovanessian A., Wallace W.D., et al. Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation. Semin Respir Crit Care Med 2013, 34(3):336-351.
8. Petersen T.H., Calle E.A., Zhao L., et al. Tissue-engineered lungs for in vivo implantation. Science 2010, 329(5991):538-541.
9. Ott H.C., Clippinger B., Conrad C., et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 2010, 16(8):927-933.
10. Crapo P.M., Gilbert T.W., Badylak S.F. An overview of tissue and whole organ decellularization processes. Biomaterials 2011, 32(12):3233-3243.
11. Gilpin S.E., Guyette J.P., Gonzalez G., et al. Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale. J Heart Lung Transplant 2014, 33(3):298-308.
12. Petersen T.H., Calle E.A., Colehour M.B., et al. Matrix composition and mechanics of decellularized lung scaffolds. Cells Tissues Organs 2012, 195(3):222-231.
13. Wagner D.E., Bonenfant N.R., Sokocevic D., et al. Three-dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration. Biomaterials 2014, 35(9):2664-2679.
14. Hill R.C., Calle E.A., Dzieciatkowska M., et al. Quantification of extracellular matrix proteins from a rat lung scaffold to provide a molecular readout for tissue engineering. Mol Cell Proteomics 2015, 14(4):961-973.
15. Daly A.B., Wallis J.M., Borg Z.D., et al. Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrow-derived mesenchymal stromal cells. Tissue Eng Part A 2012, 18(1-2):1-16.
16. Bonvillain R.W., Danchuk S., Sullivan D.E., et al. A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells. Tissue Eng Part A 2012, 18(23-24):2437-2452.
17. Guyette J.P., Gilpin S.E., Charest J.M., et al. Perfusion decellularization of whole organs. Nat Protoc 2014, 9(6):1451-1468.
18. Chen P., Marsilio E., Goldstein R.H., et al. Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitro. Tissue Eng 2005, 11(9-10):1436-1448.
19. Mondrinos M.J., Koutzaki S., Jiwanmall E., et al. Engineering three-dimensional pulmonary tissue constructs. Tissue Eng 2006, 12(4):717-728.
20. Andrade C.F., Wong A.P., Waddell T.K., et al. Cell-based tissue engineering for lung regeneration. Am J Physiol Lung Cell Mol Physiol 2007, 292(2):L510-L518.
21. Suki B., Ito S., Stamenovic D., et al. Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces. J Appl Physiol (1985) 2005, 98(5):1892-1899.
22. Nichols J.E., Niles J., Riddle M., et al. Production and assessment of decellularized pig and human lung scaffolds. Tissue Eng Part A 2013, 19(17-18):2045-2062.
23. O'Neill J.D., Anfang R., Anandappa A., et al. Decellularization of human and porcine lung tissues for pulmonary tissue engineering. Ann Thorac Surg 2013, 96(3):1046-1055. [discussion: 1055-6].
24. Melo E., Garreta E., Luque T., et al. Effects of the decellularization method on the local stiffness of acellular lungs. Tissue Eng Part C Methods 2014, 20(5):412-422.
25. Wagner D.E., Bonenfant N.R., Parsons C.S., et al. Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 2014, 35(10):3281-3297.
26. Booth A.J., Hadley R., Cornett A.M., et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med 2012, 186(9):866-876.
27. Stone K.C., Mercer R.R., Gehr P., et al. Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol 1992, 6(2):235-243.
28. Li F., He J., Wei J., et al. Diversity of epithelial stem cell types in adult lung. Stem Cells Int 2015, 2015:728307.
29. Mercer R.R., Russell M.L., Roggli V.L., et al. Cell number and distribution in human and rat airways. Am J Respir Cell Mol Biol 1994, 10(6):613-624.
30. Rock J.R., Onaitis M.W., Rawlins E.L., et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A 2009, 106(31):12771-12775.
31. Evans M.J., van Winkle L.S., Fanucchi M.V., et al. Cellular and molecular characteristics of basal cells in airway epithelium. Exp Lung Res 2001, 27(5):401-415.
32. Dobbs L.G., Johnson M.D. Alveolar epithelial transport in the adult lung. Respir Physiol Neurobiol 2007, 159(3):283-300.
33. Guillot L., Nathan N., Tabary O., et al. Alveolar epithelial cells: master regulators of lung homeostasis. Int J Biochem Cell Biol 2013, 45(11):2568-2573.
34. Gonzalez R., Yang Y.H., Griffin C., et al. Freshly isolated rat alveolar type I cells, type II cells, and cultured type II cells have distinct molecular phenotypes. Am J Physiol Lung Cell Mol Physiol 2005, 288(1):L179-L189.
35. Vaughan A.E., Brumwell A.N., Xi Y., et al. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 2015, 517(7536):621-625.
36. Huang S.X., Green M.D., de Carvalho A.T., et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc 2015, 10(3):413-425.
37. Crapo J., Barry B., Gehr P., et al. Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 1982, 126(2):332-337.
38. Stone K., Mercer R., Freeman B., et al. Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue. Am Rev Respir Dis 1992, 146(2):454-456.
39. Ingram D.A., Mead L.E., Tanaka H., et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004, 104(9):2752-2760.
40. Prasain N., Lee M.R., Vemula S., et al. Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells. Nat Biotechnol 2014, 32(11):1151-1157.
41. Melero-Martin J.M., De Obaldia M.E., Kang S.-Y., et al. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res 2008, 103(2):194-202.
42. Au P., Daheron L.M., Duda D.G., et al. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood 2008, 111(3):1302-1305.
43. Samuel R., Daheron L., Liao S., et al. Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 2013, 110(31):12774-12779.
44. Aird W.C. Phenotypic heterogeneity of the endothelium. Circ Res 2007, 100(2):174-190.
45. Nolan D.J., Ginsberg M., Israely E., et al. Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev Cell 2013, 26(2):204-219.
46. Peng T., Tian Y., Boogerd C.J., et al. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature 2013, 500(7464):589-592.
47. Swift M.R., Weinstein B.M. Arterial-venous specification during development. Circ Res 2009, 104(5):576-588.
48. Au P., Tam J., Fukumura D., et al. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 2008, 111(9):4551-4558.
49. Herbert S.P., Stainier D.Y. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol 2011, 12(9):551-564.
50. Strilić B., Kučera T., Eglinger J., et al. The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell 2009, 17(4):505-515.
51. Bayless K.J., Salazar R., Davis G.E. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the αvβ3 and α5β1 integrins. Am J Pathol 2000, 156(5):1673-1683.
52. Bayless K.J., Davis G.E. The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices. J Cell Sci 2002, 115(6):1123-1136.
53. Lampugnani M.G., Orsenigo F., Rudini N., et al. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci 2010, 123(7):1073-1080.
54. Chien S. Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol 2007, 292(3):H1209-H1224.
55. Carey S.P., Charest J.M., Reinhart-King C.A. Forces during cell adhesion and spreading: implications for cellular homeostasis. Cellular and biomolecular mechanics and mechanobiology 2011, 29-69. Springer Berlin Heidelberg, Berlin. A. Gefen (Ed.).
56. Suki B., Stamenovic D., Hubmayr R. Lung parenchymal mechanics. Compr Physiol 2011, 1(3):1317-1351.
57. Waters C.M., Roan E., Navajas D. Mechanobiology in lung epithelial cells: measurements, perturbations, and responses. Compr Physiol 2012, 2(1):1-29.
58. Ingber D.E. Cellular mechanotransduction: putting all the pieces together again. FASEB J 2006, 20(7):811-827.
59. Wozniak M.A., Chen C.S. Mechanotransduction in development: a growing role for contractility. Nat Rev Mol Cell Biol 2009, 10(1):34-43.
60. Crick F. Diffusion in embryogenesis. Nature 1970, 225(5231):420-422.
61. Tabata T. Genetics of morphogen gradients. Nat Rev Genet 2001, 2(8):620-630.
62. Nelson C.M. Geometric control of tissue morphogenesis. Biochim Biophys Acta 2009, 1793(5):903-910.
63. Balestrini J.L., Niklason L.E. Extracellular matrix as a driver for lung regeneration. Ann Biomed Eng 2015, 43(3):568-576.
64. Price A.P., England K.A., Matson A.M., et al. Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded. Tissue Eng Part A 2010, 16(8):2581-2591.
65. Petersen T.H., Calle E.A., Colehour M.B., et al. Bioreactor for the long-term culture of lung tissue. Cell Transplant 2011, 20(7):1117-1126.
66. Song J.J., Kim S.S., Liu Z., et al. Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg 2011, 92(3):998-1005. [discussion: 10056].
67. Bonvillain R.W., Scarritt M.E., Pashos N.C., et al. Nonhuman primate lung decellularization and recellularization using a specialized large-organ bioreactor. J Vis Exp 2013, (82):e50825.
68. Kohn D.F., Clifford C.B. Biology and diseases of rats 2002, Academic Press, San Diego (CA).
69. Charest J.M., Okamoto T., Kitano K., et al. Design and validation of a clinical-scale bioreactor for long-term isolated lung culture. Biomaterials 2015, 52:79-87.
70. Camboni D., Philipp A., Arlt M., et al. First experience with a paracorporeal artificial lung in humans. ASAIO J 2009, 55(3):304-306.