Design and validation of a clinical-scale bioreactor for long-term isolated lung culture

Biomaterials

Volumn 52, Issue 1, 2015, Pages 79-87

  Charest, Jonathan M ^a   Okamoto, Tatsuya ^a   Kitano, Kentaro ^a   Yasuda, Atsushi ^a   Gilpin, Sarah E ^a,b   Mathisen, Douglas J ^a   Ott, Harald C ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

Ex vivo perfusion; Isolated lung culture; Lung preservation; Lung transplantation; Organ repair

Indexed keywords

BIOMIMETICS; BIOREACTORS; RESUSCITATION; TWO TERM CONTROL SYSTEMS;

CLOSED CIRCUIT SYSTEMS; EX-VIVO; FULLY AUTOMATED; LONG-TERM CULTURE; LUNG TRANSPLANTATION; NEGATIVE PRESSURES; ORGAN CULTURE SYSTEM; PRIMARY TREATMENT;

BIOLOGICAL ORGANS;

ANIMAL TISSUE; ARTICLE; BIOREACTOR; CONTROLLED STUDY; GAS EXCHANGE; HUMAN; HUMAN TISSUE; ISOLATED LUNG; METABOLISM; NEGATIVE PRESSURE VENTILATION; NONHUMAN; ORGAN DONOR; PIG; PRIORITY JOURNAL; TISSUE CULTURE; VALIDATION STUDY; ANIMAL; DEVICES; EQUIPMENT DESIGN; LUNG; ORGAN CULTURE TECHNIQUE; ORGAN PRESERVATION; PERFUSION; PHYSIOLOGY; ULTRASTRUCTURE;

SUS;

ANIMALS; BIOREACTORS; EQUIPMENT DESIGN; HUMANS; LUNG; ORGAN CULTURE TECHNIQUES; ORGAN PRESERVATION; PERFUSION; SWINE;

EID: 84932643415     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.02.016     Document Type: Article

References (26)

1. Steen S., Sjoberg T., Pierre L., Liao Q., Eriksson L., Algotsson L. Transplantation of lungs from a non-heart-beating donor. Lancet 2001, 357:825-829.
2. Steen S., Liao Q., Wierup P.N., Bolys R., Pierre L., Sjoberg T. Transplantation of lungs from non-heart-beating donors after functional assessment exvivo. Ann Thorac Surg 2003, 76:244-252. discussion 52.
3. Wierup P., Haraldsson A., Nilsson F., Pierre L., Schersten H., Silverborn M., et al. Exvivo evaluation of nonacceptable donor lungs. Ann Thorac Surg 2006, 81:460-466.
4. Cypel M., Yeung J.C., Liu M., Anraku M., Chen F., Karolak W., et al. Normothermic exvivo lung perfusion in clinical lung transplantation. NEngl J Med 2011, 364:1431-1440.
5. Cypel M., Yeung J.C., Hirayama S., Rubacha M., Fischer S., Anraku M., et al. Technique for prolonged normothermic exvivo lung perfusion. JHeart Lung Transpl 2008, 27:1319-1325.
6. Westall G.P., Levvey B.J., Salvaris E., Gooi J., Marasco S., Rosenfeldt F., et al. Sustained function of genetically modified porcine lungs in an exvivo model of pulmonary xenotransplantation. JHeart Lung Transpl 2013, 32:1123-1130.
7. Machuca T.N., Hsin M.K., Ott H.C., Chen M., Hwang D.M., Cypel M., et al. Injury-specific exvivo treatment of the donor lung: pulmonary thrombolysis followed by successful lung transplantation. Am J Respir Crit Care Med 2013, 188:878-880.
8. Sanchez P.G., Bittle G.J., Burdorf L., Pierson R.N., Griffith B.P. State of art: clinical exvivo lung perfusion: rationale, current status, and future directions. JHeart Lung Transpl 2012, 31:339-348.
9. Lee J.W., Fang X., Gupta N., Serikov V., Matthay M.A. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the exvivo perfused human lung. Proc Natl Acad Sci U S A 2009, 106:16357-16362.
10. Cypel M., Liu M., Rubacha M., Yeung J.C., Hirayama S., Anraku M., et al. Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med 2009, 1:4ra9.
11. Emaminia A., Lapar D.J., Zhao Y., Steidle J.F., Harris D.A., Laubach V.E., et al. Adenosine A(2)A agonist improves lung function during exvivo lung perfusion. Ann Thorac Surg 2011, 92:1840-1846.
12. Price A.P., England K.A., Matson A.M., Blazar B.R., Panoskaltsis-Mortari A. Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded. Tissue Eng Part A 2010, 16:2581-2591.
13. Petersen T.H., Calle E.A., Colehour M.B., Niklason L.E. Bioreactor for the long-term culture of lung tissue. Cell Transpl 2011, 20:1117-1126.
14. Ott H.C., Clippinger B., Conrad C., Schuetz C., Pomerantseva I., Ikonomou L., et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 2010, 16:927-933.
15. Song J.J., Kim S.S., Liu Z., Madsen J.C., Mathisen D.J., Vacanti J.P., et al. Enhanced invivo function of bioartificial lungs in rats. Ann Thorac Surg 2011, 92:998-1005. discussion-6.
16. Bonvillain R.W., Scarritt M.E., Pashos N.C., Mayeux J.P., Meshberger C.L., Betancourt A.M., et al. Nonhuman primate lung decellularization and recellularization using a specialized large-organ bioreactor. JVis Exp 2013, e50825.
17. Grasso F., Engelberts D., Helm E., Frndova H., Jarvis S., Talakoub O., et al. Negative-pressure ventilation: better oxygenation and less lung injury. Am J Respir Crit Care Med 2008, 177:412-418.
18. Engelberts D., Malhotra A., Butler J.P., Topulos G.P., Loring S.H., Kavanagh B.P. Relative effects of negative versus positive pressure ventilation depend on applied conditions. Intensive Care Med 2012, 38:879-885.
19. Carpenter A.E., Jones T.R., Lamprecht M.R., Clarke C., Kang I.H., Friman O., et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol 2006, 7:R100.
20. Kamentsky L., Jones T.R., Fraser A., Bray M.A., Logan D.J., Madden K.L., et al. Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics 2011, 27:1179-1180.
21. Cypel M., Rubacha M., Yeung J., Hirayama S., Torbicki K., Madonik M., et al. Normothermic exvivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transpl 2009, 9:2262-2269.
22. Valenza F., Rosso L., Coppola S., Froio S., Colombo J., Dossi R., et al. beta-adrenergic agonist infusion during extracorporeal lung perfusion: effects on glucose concentration in the perfusion fluid and on lung function. JHeart Lung Transpl 2012, 31:524-530.
23. Gilpin S.E., Guyette J.P., Gonzalez G., Ren X., Asara J.M., Mathisen D.J., et al. Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale. JHeart Lung Transpl 2014, 33:298-308.
24. Machuca T.N., Cypel M. Exvivo lung perfusion. JThorac Dis 2014, 6:1054-1062.
25. Koike T., Yeung J.C., Cypel M., Rubacha M., Matsuda Y., Sato M., et al. Kinetics of lactate metabolism during acellular normothermic exvivo lung perfusion. JHeart Lung Transpl 2011, 30:1312-1319.
26. Valenza F., Rosso L., Pizzocri M., Salice V., Umbrello M., Conte G., et al. The consumption of glucose during exvivo lung perfusion correlates with lung edema. Transpl Proc 2011, 43:993-996.