Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells

Nature Biotechnology

Volumn 32, Issue 11, 2014, Pages 1151-1157

  Prasain, Nutan ^a   Lee, Man Ryul ^a   Vemula, Sasidhar ^a   Meador, Jonathan Luke ^a   Yoshimoto, Momoko ^a   Ferkowicz, Michael J ^a   Fett, Alexa ^a   Gupta, Manav ^a   Rapp, Brian M ^a   Saadatzadeh, Mohammad Reza ^a   Ginsberg, Michael ^b   Elemento, Olivier ^c   Lee, Younghee ^d   Voytik Harbin, Sherry L ^e   Chung, Hyung Min ^f   Hong, Ki Sung ^g   Reid, Emma ^h   O'Neill, Christina L ^h   Medina, Reinhold J ^h   Stitt, Alan W ^h   Murphy, Michael P ^a   Rafii, Shahin ^b   Broxmeyer, Hal E ^a   Yoder, Mervin C ^a   more..

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e PURDUE UNIVERSITY   (United States)

^f Konkuk University School of Medicine   (South Korea)

^g CHA University   (South Korea)

^h QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; CELL GROWTH; CELL SIGNALING; CELLS; CLONE CELLS; CYTOLOGY; MAMMALS; STEM CELLS;

EMBRYONIC STEM CELLS; ENDOTHELIAL COLONY FORMING CELLS; ENDOTHELIAL FUNCTION; FORMATION POTENTIAL; HUMAN VESSELS; HUMAN-INDUCED PLURIPOTENT STEM CELLS; PLURIPOTENT STEM CELLS; VASCULAR DISEASE;

ENDOTHELIAL CELLS;

NEUROPILIN 1; VASCULOTROPIN 165; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORD BLOOD ENDOTHELIAL COLONY FORMING CELL; CRITICAL LIMB ISCHEMIA; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULAR SURGERY; ANIMAL; CYTOLOGY; FETUS BLOOD; GENETICS; METABOLISM; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYONIC STEM CELLS; ENDOTHELIAL CELLS; FETAL BLOOD; HUMANS; MICE; NEUROPILIN-1; PLURIPOTENT STEM CELLS; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84983143261     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3048     Document Type: Article

References (29)

1. Lin, Y., Weisdorf, D.J., Solovey, A. & Hebbel, R.P. Origins of circulating endothelial cells and endothelial outgrowth from blood. J. Clin. Invest. 105, 71-77 (2000).
2. Medina, R.J., O'Neill, C.L., Humphreys, M.W., Gardiner, T.A. & Stitt, A.W. Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy. Invest. Ophthalmol. Vis. Sci. 51, 5906-5913 (2010).
3. Moubarik, C. et al. Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke. Stem Cell Rev. 7, 208-220 (2011).
4. Yoder, M.C. et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109, 1801-1809 (2007).
5. Ingram, D.A. et al. Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood 105, 2783-2786 (2005).
6. Ingram, D.A. et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104, 2752-2760 (2004).
7. Critser, P.J., Kreger, S.T., Voytik-Harbin, S.L. & Yoder, M.C. Collagen matrix physical properties modulate endothelial colony forming cell-derived vessels in vivo. Microvasc. Res. 80, 23-30 (2010).
8. Schwarz, T.M. et al. Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy. Arterioscler. Thromb. Vasc. Biol. 32, e13-e21 (2012).
9. Kang, K.T., Coggins, M., Xiao, C., Rosenzweig, A. & Bischoff, J. Human vasculogenic cells form functional blood vessels and mitigate adverse remodeling after ischemia reperfusion injury in rats. Angiogenesis 16, 773-784 (2013).
10. Huang, X.T. et al. Intracerebroventricular transplantation of ex vivo expanded endothelial colony-forming cells restores blood-brain barrier integrity and promotes angiogenesis of mice with traumatic brain injury. J. Neurotrauma 30, 2080-2088 (2013).
11. Heo, S.C. et al. WKYMVm-induced activation of formyl peptide receptor 2 stimulates ischemic neovasculogenesis by promoting homing of endothelial colony forming cells. Stem Cells 32, 779-790 (2013).
12. Stroncek, J.D., Ren, L.C., Klitzman, B. & Reichert, W.M. Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model. Acta Biomater. 8, 201-208 (2012).
13. Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998).
14. Yu, J. et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797-801 (2009).
15. Cimato, T. et al. Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression. Circulation 119, 2170-2178 (2009).
16. Choi, K.D. et al. Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells 27, 559-567 (2009).
17. James, D. et al. Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat. Biotechnol. 28, 161-166 (2010).
18. Goldman, O. et al. A boost of BMP4 accelerates the commitment of human embryonic stem cells to the endothelial lineage. Stem Cells 27, 1750-1759 (2009).
19. Feng, Q. et al. Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Stem Cells 28, 704-712 (2010).
20. Sone, M. et al. Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration. Arterioscler. Thromb. Vasc. Biol. 27, 2127-2134 (2007).
21. Ginsberg, M. et al. Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFbeta suppression. Cell 151, 559-575 (2012).
22. Zachary, I.C. How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns. Biochem. Soc. Trans. 39, 1583-1591 (2011).
23. Evseenko, D. et al. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc. Natl. Acad. Sci. USA 107, 13742-13747 (2010).
24. Cho, S.W. et al. Improvement of postnatal neovascularization by human embryonic stem cell derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation 116, 2409-2419 (2007).
25. Kuilman, T., Michaloglou, C., Mooi, W.J. & Peeper, D.S. The essence of senescence. Genes Dev. 24, 2463-2479 (2010).
26. Herzog, B., Pellet-Many, C., Britton, G., Hartzoulakis, B. & Zachary, I.C. VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation. Mol. Biol. Cell 22, 2766-2776 (2011).
27. Pan, Q. et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11, 53-67 (2007).
28. Uniewicz, K.A., Cross, M.J. & Fernig, D.G. Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis. J. Biol. Chem. 286, 12-23 (2011).
29. Lippmann, E.S. et al. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat. Biotechnol. 30, 783-791 (2012).