Changes of body composition and circulating adipokines in response to Nigella sativa oil with a calorie restricted diet in obese women

Journal of Herbal Medicine

Volumn 6, Issue 2, 2016, Pages 67-72

  Mahdavi, Reza ^a   Alizadeh​, Mohammad ^b   Namazi, Nazli ^b   Farajnia, Safar ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Body fat distribution; Hormone; Nigella sativas; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; INSULIN; NIGELLA SATIVA EXTRACT; NIGELLA SATIVA OIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; SUNFLOWER OIL; UNCLASSIFIED DRUG; VEGETABLE OIL;

ADULT; ARTICLE; BLACK CUMIN; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; CHEMICAL PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG RESPONSE; DRUG SAFETY; FAT MASS; FEMALE; HORMONE RELEASE; HUMAN; INSULIN SENSITIVITY; LOW CALORY DIET; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH PAIN;

EID: 84963945649     PISSN: 22108033     EISSN: 22108041     Source Type: Journal    
DOI: 10.1016/j.hermed.2016.03.003     Document Type: Article

References (32)

1. Ahmadian, M., Suh, J.M., Hah, N., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M., PPAR gamma signaling and metabolism: the good, the bad and the future. Nat. Med. 99:5 (2013), 557–566.
2. Ali, B.H., Blunden, G., Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. 17:4 (2003), 299–305.
3. Ballard, C.G., O. Brien, J.T., Reichelt, K., Perry, E.K., Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. J. Clin. Psychiatry 63:7 (2002), 553–558.
4. Bamosa, A.O., A review on the hypoglycemic effect of nigella sativa and thymoquinone. Saudi. J. Health. Sci., 3(1), 2015, 2.
5. Benhaddou-Andaloussi, A., Martineau, L.C., Vallerand, D., Haddad, Y., Afshar, A., Settaf, A., et al. Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells. Diabetes Obes. Metab. 12:2 (2010), 148–157.
6. Datau, E.A., Surachmanto, E., Pandelaki, K., Langi, J.A., Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med. Indones. 42 (2010), 130–136.
7. Fiaschi, T., Magherini, F., Gamberi, T., Modesti, P.A., Modesti, A., Adiponectin as a tissue regenerating hormone: more than a metabolic function. Cell. Mol. Life Sci. 71:10 (2014), 1917–1925.
8. Gonzales, G.F., Gonzales, C., A randomized, double-blind placebo-controlled study on acceptability, safety and efficacy of oral administration of sachainchi oil (Plukenetia volubilis L.) in adult human subjects. Food Chem. Toxicol. 65 (2014), 168–176.
9. Gown, Christine Mc, Birerdinc, Aybike, Younossi, Zobair, Adipose tissue as an endocrine organ. Clin. Liver Dis. 18:1 (2014), 41–58.
10. Hadi, S., Mirmiran, P., Hosseinpour-Niazi, S., Hedayati, M., Azizi, F., Effect of nigella sativa oil extract on lipid profiles in type 2 diabetic patients: a randomized, double blind, placebo-controlled clinical trial. Iran. J. Endocrinol. Metabol. 16:6 (2015), 411–418.
11. Harwood, H., The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology 63:1 (2012), 57–75.
12. Heshmati, J., Namazi, N., Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: a systematic review. Complement. Ther. Med. 23 (2015), 629–631.
13. Heshmati, J., Namazi, N., Memarzadeh, M.R., Taghizadeh, M., Kolahdooz, F., Nigella sativa oil affects glucose metabolism and lipid concentrations in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Food. Res. Int. 70 (2015), 87–93.
14. Hrebicek, J., Janout, V., Malinčíková, J., Horáková, D., Čížek, L., Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J. Clin. Endocrinol. Metab., 87(1), 2002 144–144.
15. Kotidis, E.V., Koliakos, G.G., Baltzopoulos, V.G., Ioannidis, K.N., Yovos, J.G., Papavramidis, S.T., Serum ghrelin, leptin and adiponectin levels before and after weight loss: comparison of three methods of treatment–a prospective study. Obes. Surg. 16:11 (2006), 1425–1432.
16. Le, P.M., Benhaddou-Andaloussi, A., Elimadi, A., Settaf, A., Cherrah, Y., Haddad, P.S., The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J. Ethnopharmacol. 94:2 (2004), 251–259.
17. Madsen, E.L., Rissanen, A., Bruun, J.M., Skogstrand, K., Tonstad, S., Hougaard, D.M., et al. Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study. Eur. J. Endocrinol. 158:2 (2008), 179–187.
18. Mahdavi, R., Namazi, N., Alizadeh, M., Farajnia, S., Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food. Funct. 6 (2015), 2041–2048.
19. Meddah, R., Moulay El, Bruno, E., Lahcen, M., Ali, B., et al. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J. Ethnopharmacol. 121:3 (2009), 419–424.
20. Najmi, A., Nasiruddin, M., Khan, R.A., Haque, S.F., Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int. J. Diabetes Dev. Ctries, 28, 2008, 11.
21. Namazi, N., Mahdavi, R., Alizadeh, M., Farajnia, S., Oxidative stress responses to nigella sativa oil concurrent with a low-calorie diet in obese women: a randomized, double-blind controlled clinical trial. Phytother. Res., 2015, 10.1002/ptr.5417.
22. Namazi, N., Aliasgharzadeh, S., Mahdavi, R., Kolahdooz, F., Accuracy of the common predictive equations for estimating resting energy expenditure among normal and overweight girl university students. J. Am. Coll. Nutr., 1(7), 2015.
23. Puglisi, M.J., Fernandez, M.L., Modulation of C-reactive protein, tumor necrosis factor-α, and adiponectin by diet, exercise, and weight loss. J. Nutr. 138:12 (2008), 2293–2296.
24. Qidwai, W., Hamza, H.B., Qureshi, R., Gilan, A., Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J. Altern. Complement. Med. 15 (2009), 639–644.
25. Ryan, A.S., Nicklas, B.J., Berman, D.M., Elahi, D., Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int. J. Obes. 27:9 (2003), 1066–1071.
26. Selvaraj, R.K., Shanmugasundaram, R., Klasing, K.C., Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory response. Comp. Biochem. Physiol. Part A: Mol. Integr. Physiol 157:3 (2010), 198–203.
27. Torres-Fuentes, C., Schellekens, H., Dinan, T.G., Cryan, J.F., A natural solution for obesity: bioactives for the prevention and treatment of weight gain. A review. Nutr. Neurosci. 18:2 (2015), 49–65.
28. Verreth, W., De Keyzer, D., Pelat, M., Verhamme, P., Ganame, J., Bielicki, J.K., et al. Weight loss-associated induction of peroxisome proliferator–activated receptor-α and Peroxisome proliferator–activated receptor-γ correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation 110:20 (2004), 3259–3269.
29. Woo, C.C., Loo, S.Y., Gee, V., Yap, C.W., Sethi, G., Kumar, A.P., et al. Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. Biochem. Pharmacol. 82:5 (2011), 464–475.
30. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:8 (2001), 941–946.
31. Yun, J.W., Possible anti-obesity therapeutics from nature: review. Phytochemistry 71:14 (2010), 1625–1641.
32. Zaoui, A., Cherrah, Y., Mahassini, N., Alaoui, K., Amarouch, H., Hassar, M., Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine 9:1 (2002), 69–74.