Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants

FASEB Journal

Volumn 30, Issue 4, 2016, Pages 1590-1598

  Hehle, Verena K ^a   Paul, Matthew J ^a   Roberts, Victoria A ^a,b   Van Dolleweerd, Craig J ^a   Ma, Julian K C ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody engineering; Degradation; Proteolysis

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; PROTEINASE; RECOMBINANT ANTIBODY; SOLVENT; PEPTIDE HYDROLASE; RECOMBINANT PROTEIN;

ANTIBODY STRUCTURE; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DEGRADATION; GEL ELECTROPHORESIS; GENE SEQUENCE; HEAVY CHAIN; LIGHT CHAIN; MUTAGENESIS; MUTANT; NICOTIANA TABACUM; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; MOUSE; MUTATION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; TOBACCO; TRANSGENIC PLANT; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; BLOTTING, WESTERN; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE HYDROLASES; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN; TOBACCO;

EID: 84963865151     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-283226     Document Type: Article

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