Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation

Alcoholism: Clinical and Experimental Research

Volumn 40, Issue 5, 2016, Pages 1044-1051

  Quintanilla, María Elena ^a   Rivera Meza, Mario ^a,b   Berríos Cárcamo, Pablo ^a   Salinas Luypaert, Catalina ^a   Herrera Marschitz, Mario ^a   Israel, Yedy ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Acquisition; Maintenance; N Acetyl Cysteine Saccharin; Voluntary Ethanol Drinking

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; SACCHARIN;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL USE DISORDER; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG EFFECT; FEMALE; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; ANIMAL; DRUG EFFECTS; DRUG SELF ADMINISTRATION; DRUG THERAPY; MALE; TIME FACTOR;

ACETYLCYSTEINE; ALCOHOL DRINKING; ANIMALS; MALE; MOTIVATION; RATS; SACCHARIN; SELF ADMINISTRATION; TIME FACTORS;

EID: 84963815275     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.13031     Document Type: Article

References (47)

1. Amen SL, Piacentine LB, Ahmad ME, Li SJ, Mantsch JR, Risinger RC, Baker DA (2011) Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology 36:871-878.
2. Aragon CM, Amit Z (1992) The effect of 3-amino-1, 2, 4-triazole on voluntary ethanol consumption: evidence for brain catalase involvement in the mechanism of action. Neuropharmacology 31:709-712.
3. Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, Kalivas PW (2003) Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6:743-749.
4. Browne R, Sloan D, Fahy S, Keating S, Moran C, O'Connor J (1998) Detection of benzodiazepine abuse in opiate addicts. Ir Med J 91:18-19.
5. Chen J, Nam HW, Lee MR, Hinton DJ, Choi S, Kim T, Kawamura T, Janak PH, Choi DS (2010) Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. Behav Brain Res 208:636-642.
6. Corbit LH, Chieng BC, Balleine BW (2014) Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology 39:1893-1901.
7. Das SC, Yamamoto BK, Hristov AM, Sari Y (2015) Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats. Neuropharmacology 97:67-74.
8. Ding ZM, Rodd ZA, Engleman EA, Bailey JA, Lahiri DK, McBride WJ (2012) Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. Addict Biol 18:297-306.
9. Ducret E, Puaud M, Lacoste J, Belin-Rauscent A, Fouyssac M, Dugast E, Murray JE, Everitt BJ, Houeto JL, Belin D (2015) N-acetylcysteine facilitates self-imposed abstinence after escalation of cocaine intake. Biol Psychiatry. doi: 10.1016/j.biopsych.2015.09.019. [Epub ahead of print].
10. Font L, Aragon CM, Miquel M (2006) Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine. Behav Brain Res 171:78-86.
11. Gass JT, Sinclair CM, Cleva RM, Widholm JJ, Olive MF (2011) Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. Addict Biol 16:215-228.
12. Griffin WC III, Haun HL, Hazelbaker CL, Ramachandra VS, Becker HC (2014) Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. Neuropsychopharmacology 39:707-717.
13. Hauser SR, Wilden JA, Deehan GA Jr, McBride WJ, Rodd ZA (2014) Cocaine influences alcohol-seeking behavior and relapse drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res 38:2678-2686.
14. Herrera-Marschitz M, You ZB, Goiny M, Meana JJ, Silveira R, Godukhin OV, Chen Y, Espinoza S, Pettersson E, Loidl CF, Lubec G, Andersson K, Nylander I, Terenius L, Ungerstedt U (1996) On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis. J Neurochem 66:1726-1735.
15. Hughes JR, Oliveto AH, MacLaughlin M (2000) Is dependence on one drug associated with dependence on other drugs? The cases of alcohol, caffeine and nicotine. Am J Addict 9:196-201.
16. Israel Y, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M (2015) The "first hit" toward alcohol reinforcement: role of ethanol metabolites. Alcohol Clin Exp Res 39:776-786.
17. Kampov-Polevoy AB, Eick C, Boland G, Khalitov E, Crews FT (2004) Sweet liking, novelty seeking, and gender predict alcoholic status. Alcohol Clin Exp Res 28:1291-1298.
18. Karahanian E, Quintanilla ME, Tampier L, Rivera-Meza M, Bustamante D, Gonzalez-Lira V, Morales P, Herrera-Marschitz M, Israel Y (2011) Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Alcohol Clin Exp Res 35:606-612.
19. Karahanian E, Rivera-Meza M, Tampier L, Quintanilla ME, Herrera-Marschitz M, Israel Y (2015) Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats. Addict Biol 20:336-344.
20. Kau KS, Madayag A, Mantsch JR, Grier MD, Abdulhameed O, Baker DA (2008) Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking. Neuroscience 155:530-537.
21. Knackstedt LA, Melendez RI, Kalivas PW (2010) Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry 67:81-84.
22. LaRowe SD, Kalivas PW, Nicholas JS, Randall PK, Mardikian PN, Malcolm RJ (2013) A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict 22:443-452.
23. Ledesma JC, Baliño P, Aragon CMG (2014) Reduction in central H2O2 levels prevents voluntary ethanol intake in mice: a role for the brain catalase-H2O2 system in alcohol binge drinking. Alcohol Clin Exp Res 38:60-67.
24. Lüscher C (2013) Drug-evoked synaptic plasticity causing addictive behavior. J Neurosci 33:17641-17646.
25. Madayag A, Lobner D, Kau KS, Mantsch JR, Abdulhameed O, Hearing M, Grier MD, Baker DA (2007) Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine. J Neurosci 27:13968-13976.
26. Mardones J, Segovia-Riquelme N (1983) Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav Toxicol Teratol 5:171-178.
27. McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM (2014) Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs 28:95-106.
28. Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK (2005) Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci 25:6389-6393.
29. Orrico A, Hipólito L, Sanchez-Catalan MJ, Martí-Prats L, Zornoza T, Granero L, Polache A (2013) Efficacy of D-penicillamine, a sequestering acetaldehyde agent, in the prevention of alcohol relapse-like drinking in rats. Psychopharmacologia 228:563-575.
30. Pastor R, Kamens HM, McKinnon CS, Ford MM, Phillips TJ (2010) Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization. Addict Biol 15:324-335.
31. Peana AT, Giuliano V, Rosas M, Sabariego M, Acquas E (2013) Effects of L-cysteine on reinstatement of ethanol-seeking behavior and reinstatement-elicited extracellular signal-regulated kinase phosphorylation in the rat nucleus accumbens shell. Alcohol Clin Exp Res 37:E329-E337.
32. Peana AT, Muggironi G, Bennardini F (2014) Change of cystine/glutamate antiporter expression in ethanol-dependent rats. Front Neurosci 8:311.
33. Peana AT, Muggironi G, Calvisi G, Enrico P, Mereu M, Nieddu M, Boatto G, Diana M (2010) L-cysteine reduces oral ethanol self-administration and reinstatement of ethanol-drinking behavior in rats. Pharmacol Biochem Behav 94:431-437.
34. Peana AT, Porcheddu V, Bennardini F, Carta A, Rosas M, Acquas E (2015) Role of ethanol-derived acetaldehyde in operant oral self-administration of ethanol in rats. Psychopharmacology 232:4269-4276.
35. Quintanilla ME, Israel Y, Sapag A, Tampier L (2006) The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake. Addict Biol 11:310-323.
36. Quintanilla ME, Tampier L, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y (2012) Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence. Alcohol Clin Exp Res 36:517-522.
37. Ramirez-Niño AM, D'Souza MS, Markou A (2013) N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology 225:473-482.
38. Rotzinger S, Smith BR, Amit Z (1994) Catalase inhibition attenuates the acquisition of ethanol and saccharin-quinine consumption in laboratory rats. Behav Pharmacol 5:203-209.
39. Sari Y, Franklin KM, Alazizi A, Rao PS, Bell RL (2013a) Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats. Neuroscience 241:229-238.
40. Sari Y, Sreemantula SN, Lee MR, Choi D-S (2013b) Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats. J Mol Neurosci 51:779-787.
41. Tampier L, Quintanilla ME (2005) Saccharin consumption and the effect of a long-term exposure to a sweetened alcoholic solution in high- (UChB) and low- (UChA) alcohol-drinking rats. Alcohol 37:47-52.
42. Tampier L, Quintanilla ME (2009) Effect of concurrent saccharin intake on ethanol consumption by high-alcohol-drinking (UChB) rats. Addict Biol 14:276-282.
43. Tampier L, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y (2013) The alcohol deprivation effect: marked inhibition by anticatalase gene administration into the ventral tegmental area in rats. Alcohol Clin Exp Res 37:1278-1285.
44. Tampier L, Quintanilla ME, Mardones J (1995) Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats. Alcohol 12:341-344.
45. Warr O, Takahashi M, Attwell D (1999) Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange. J Physiol 514(Pt3):783-793.
46. Weiland A, Garcia S, Knackstedt LA (2015) Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Front Pharmacol 6:44.
47. Zhou J, Coles LD, Kartha RV, Nash N, Mishra U, Lund TC, Cloyd JC (2015) Intravenous administration of stable-labeled N-acetylcysteine demonstrates an indirect mechanism for boosting glutathione and improving redox status. J Pharm Sci 104:2619-2626.