Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats

Addiction Biology

Volumn 20, Issue 2, 2015, Pages 336-344

  Karahanian, Eduardo ^a   Rivera Meza, Mario ^b   Tampier, Lutske ^b   Quintanilla, María Elena ^b   Herrera Marschitz, Mario ^b   Israel, Yedy ^b  

^a UNIVERSIDAD AUTÓNOMA DE CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Acetaldehyde; ADE; chronic ethanol intake; lentiviral vector; VTA

Indexed keywords

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; LENTIVIRUS VECTOR; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, RAT; MITOCHONDRIAL PROTEIN;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINGE DRINKING; COMPARATIVE STUDY; CONTROLLED STUDY; DRINKING BEHAVIOR; ENZYME ACTIVITY; GENETIC CODE; HEK293 CELL LINE; NONHUMAN; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM; ALCOHOLISM; ANIMAL; DRUG SEEKING BEHAVIOR; GENE VECTOR; GENETICS; LENTIVIRINAE; METABOLISM; REINFORCEMENT;

ACETALDEHYDE; ALCOHOL DRINKING; ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ANIMALS; BINGE DRINKING; DRUG-SEEKING BEHAVIOR; GENETIC VECTORS; LENTIVIRUS; MITOCHONDRIAL PROTEINS; RATS; REINFORCEMENT (PSYCHOLOGY); VENTRAL TEGMENTAL AREA;

EID: 84923041900     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12130     Document Type: Article

References (51)

1. Agabio R, Carais MAM, Lobina C, Pani M, Reai R, Vacca G, Gessa GL, Colombo G, (2000) Development of short-lasting alcohol deprivation effect in Sardinian alcohol-preferring rat. Alcohol 21: 59-62.
2. Aragon CM, Amit Z, (1992) The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: evidence for brain catalase involvement in the mechanism of action. Neuropharmacology 31: 709-712.
3. 2 system. Biochem Pharmacol 44: 93-98.
4. Bell RL, Rodd ZA, Lumeng A, Murphy JM, McBride WJ, (2006) The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol 11: 270-288.
5. Bell RL, Rodd ZA, Schultz JA, Peper CL, Lumeng L, Murphy JM, McBride WJ, (2008) Effects of short deprivations and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats. Alcohol 42: 407-416.
6. Bragulat V, Dzemidzic M, Talavage T, Davidson D, O'Connor SJ, Kareken DA, (2008) Alcohol sensitizes cerebral responses to odors of alcoholic drinks: an fMRI study. Alcohol Clin Exp Res 32: 1124-1134.
7. Brown ZW, Amit Z, Rockman GE, (1979) Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats. Psychopharmacology (Berl) 64: 271-276.
8. Chaudhri N, Woods CA, Sahuque LL, Gill YM, Janak PH, (2013) Unilateral inactivation of the basolateral amygdala attenuates context-induced renewal of Pavlovian-conditioned alcohol-seeking. Eur J Neurosci 38: 2751-2761.
9. Cohen G, Sinet PM, Heikkila R, (1980) Ethanol oxidation by rat brain in vivo. Alcohol Clin Exp Res 4: 366-370.
10. Correa M, Salamone JD, Segovia KN, Pardo M, Longoni R, Spina L, Peana AT, Vinci S, Acquas E, (2012) Piecing together the puzzle of acetaldehyde as a neuroactive agent. Neurosci Biobehav Rev 36: 404-430.
11. Deehan GA Jr., Brodie MS, Rodd ZA, (2013) What is in that drink: the biological actions of ethanol, acetaldehyde, and salsolinol. Curr Top Behav Neurosci 13: 163-184.
12. Engleman EA, Ding Z-M, Oster SM, Toalston JE, Bell RL, Murphy JM, McBride WJ, Rodd ZA, (2009) Ethanol is self-administered into the nucleus accumbens shell but not core: evidence of genetic sensitivity. Alcohol Clin Exp Res 33: 2162-2171.
13. Font L, Aragon CMG, Miquel M, (2006) Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine. Behav Brain Res 171: 78-86.
14. Gill T, Lavine A, (2013) Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction. J Biol Chem 288: 26246-26255.
15. Halliwell B, (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97: 1634-1658.
16. Heyser JC, Schulteis G, Koob GF, (1997) Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res 21: 784-791.
17. Jeng JJ, Weiner H, (1991) Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli. Arch Biochem Biophys 289: 214-222.
18. Karahanian E, Ocaranza P, Israel Y, (2005) Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA. Alcohol Clin Exp Res 29: 1384-1389.
19. Karahanian E, Quintanilla ME, Tampier L, Rivera-Meza M, Bustamante D, Gonzalez Lira V, Morales P, Herrera-Marschitz M, Israel Y, (2011) Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Alcohol Clin Exp Res 35: 606-612.
20. Klyosov AA, (1996) Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes. Biochemistry 35: 4457-4467.
21. Laviolette SR, Van der-Kooy D, (2004) GABAa receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state. Eur J Neurosci 20: 2179-2187.
22. Morgan D, Smith MA, Roberts DCS, (2005) Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats. Psychopharmacology (Berl) 178: 309-316.
23. Orrico A, Hipolito L, Sanchez- Catalan MJ, Marti-Prats L, Zornoza T, Granero L, Polache A, (2013) Efficacy of D-penicillamine, a sequestering acetaldehyde agent, in the prevention of alcohol relapse drinking in rats. Psychopharmacology (Berl) 228: 563-575.
24. Oster SM, Toalston JE, Kuc KA, Pommer TJ, Murphy JM, Lumeng L, Bell RL, McBride WJ, Rodd ZA, (2006) Effect of multiple alcohol deprivations on operant ethanol self-administration by high-ethanol drinking replicate rat lines. Alcohol 38: 155-164.
25. Paxinos G, Watson C, (1986) The Rat Brain in Stereotaxic Coordinates. New York: Academic Press.
26. Perkins KA, Ciccocioppo M, Jacobs L, Doyle T, Caggiula A, (2003) The subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking. Exp Clin Psychopharmacol 11: 269-275.
27. Peterson DR, Tabakoff B, (1979) Characterization of brain acetaldehyde oxidizing systems in the mouse. Drug Alcohol Depend 4: 137-144.
28. Quintanilla ME, Israel Y, Sapag A, Tampier L, (2006) The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake. Addict Biol 11: 310-323.
29. Quintanilla ME, Tampier L, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y, (2012) Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence. Alcohol Clin Exp Res 36: 517-522.
30. Quintanilla ME, Tampier L, Sapag A, Gerdtzen Z, Israel Y, (2007) Sex differences, alcohol dehydrogenaser, acetaldehyde burst and aversion to ethanol in the rat: a systems perspective. Am J Physiol Endocrinol Metab 293: E531-E537.
31. Rivera-Meza M, Quintanilla ME, Tampier L, Mura CV, Sapag A, Israel Y, (2010) Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. FASEB J 24: 266-274.
32. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, Li T-K, McBride WJ, (2003) Effect of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats. Neuropsychopharmacology 28: 1614-1621.
33. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ, (2009) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addict Biol 14: 152-164.
34. Rodd ZA, Bell RL, Zhang Y, Murphy JM, Goldstein A, Zaffaroni A, Li TK, McBride WJ, (2005) Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin. Neuropsychopharmacology 30: 330-338.
35. Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, Li T-K, (2001) Effect of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats. Alcohol Clin Exp Res 25: 1140-1150.
36. Serra S, Brunetti G, Vacca G, Lobina C, Carai MAM, Gessa GL, Colombo G, (2003) Stable preference for high ethanol concentrations after ethanol deprivation in Sardinian alcohol-preferring (sP) rats. Alcohol 29: 101-108.
37. Sinclair JD, Li T-K, (1989) Long and short alcohol deprivation effects on AA and P alcohol-preferring rats. Alcohol 6: 505-509.
38. Sinclair JD, Senter RJ, (1968) Development of an alcohol-deprivation effect in rats. Q J Stud Alcohol 29: 863-867.
39. Sinclair JD, Walker S, Jordan W, (1973) Behavioral and physiological changes associated with various durations of alcohol deprivation in rats. Q J Stud Alcohol 34: 544-757.
40. Spanagel R, Hölter SM, (1999) Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcohol 34: 231-243.
41. Stowell A, Hillbom M, Salaspuro M, Lindros KO, (1980) Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods. Adv Exp Med Biol 132: 635-645.
42. Tabakoff B, Anderson RA, Ritzmann RF, (1976) Brain acetaldehyde after ethanol administration. Biochem Pharmacol 25: 1305-1309.
43. Tampier L, Mardones J, (1979) Catalase mediated oxidation of ethanol by rat brain homogenates. IRCS Med Sci 7: 384.
44. Tampier L, Quintanilla ME, Mardones J, (1995) Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats. Alcohol 12: 341-344.
45. Tampier L, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y, (2013) The alcohol deprivation effect (ADE): marked inhibition by anticatalase gene administration into the ventral tegmental area in rats. Alcohol Clin Exp Res 37: 1278-1285.
46. Tsiang MT, Janak PH, (2006) Alcohol seeking in C75BL6 mice induced by conditions cues and contexts in the extinction-reinstatament model. Alcohol 38: 81-88.
47. Vargas-Perez H, Ting-A-Kee R, van der Kooy D, (2009) Different neural systems mediate morphine reward and its spontaneous withdrawal aversion. Eur J Neurosci 29: 2029-2034.
48. Vengeliene V, Bahteler D, Danysz W, Spanagel R, (2005) The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 48: 822-829.
49. Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R, (2009) Compulsive alcohol drinking in rodents. Addict Biol 14: 384-396.
50. Vengeliene V, Noori HR, Spanagel R, (2013) The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats. Alcohol Clin Exp Res 37: 322-328.
51. Zimatkin SM, Pronko SP, Vasiliou V, Gonzalez FJ, Deitrich RA, (2006) Enzymatic mechanisms of ethanol oxidation in the brain. Alcohol Clin Exp Res 30: 1500-1505.