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Volumn 10, Issue 7, 2016, Pages 993-1007

KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes

Author keywords

Breast cancer subtypes; Kallikrein related peptidase 6 (KLK6); Long term survival outcome score; miR 34a; miRNAs; Pathway analysis

Indexed keywords

COMPLEMENTARY DNA; KALLIKREIN 6; MICRORNA; MICRORNA 146A; MICRORNA 34A; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; SERINE PROTEINASE; 3' UNTRANSLATED REGION; KALLIKREIN; KLK6 PROTEIN, HUMAN;

EID: 84963624387     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2016.03.008     Document Type: Article
Times cited : (22)

References (61)
  • 1
    • 0029844185 scopus 로고    scopus 로고
    • A novel protease homolog differentially expressed in breast and ovarian cancer
    • Anisowicz, A., Sotiropoulou, G., Stenman, G., Mok, S.C., Sager, R., A novel protease homolog differentially expressed in breast and ovarian cancer. Mol. Med. 2 (1996), 624–636.
    • (1996) Mol. Med. , vol.2 , pp. 624-636
    • Anisowicz, A.1    Sotiropoulou, G.2    Stenman, G.3    Mok, S.C.4    Sager, R.5
  • 2
    • 3242786608 scopus 로고    scopus 로고
    • Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation
    • Bayés, A., Tsetsenis, T., Ventura, S., Vendrell, J., Aviles, F.X., Sotiropoulou, G., Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation. Biol. Chem. 385 (2004), 517–524.
    • (2004) Biol. Chem. , vol.385 , pp. 517-524
    • Bayés, A.1    Tsetsenis, T.2    Ventura, S.3    Vendrell, J.4    Aviles, F.X.5    Sotiropoulou, G.6
  • 3
    • 52149102044 scopus 로고    scopus 로고
    • Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells
    • Bhaumik, D., Scott, G.K., Schokrpur, S., Patil, C.K., Campisi, J., Benz, C.C., Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27 (2008), 5643–5647.
    • (2008) Oncogene , vol.27 , pp. 5643-5647
    • Bhaumik, D.1    Scott, G.K.2    Schokrpur, S.3    Patil, C.K.4    Campisi, J.5    Benz, C.C.6
  • 4
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network, Comprehensive molecular portraits of human breast tumours. Nature 490 (2012), 61–70.
    • (2012) Nature , vol.490 , pp. 61-70
    • Cancer Genome Atlas Network1
  • 5
    • 47549102771 scopus 로고    scopus 로고
    • Kallikreins as microRNA targets: an in silico and experimental-based analysis
    • Chow, T.F., Crow, M., Earle, T., El-Said, H., Diamandis, E.P., Yousef, G.M., Kallikreins as microRNA targets: an in silico and experimental-based analysis. Biol. Chem. 389 (2008), 731–738.
    • (2008) Biol. Chem. , vol.389 , pp. 731-738
    • Chow, T.F.1    Crow, M.2    Earle, T.3    El-Said, H.4    Diamandis, E.P.5    Yousef, G.M.6
  • 6
    • 84866756366 scopus 로고    scopus 로고
    • The molecular profile of luminal B breast cancer
    • Creighton, C.J., The molecular profile of luminal B breast cancer. Biologics 6 (2012), 289–297.
    • (2012) Biologics , vol.6 , pp. 289-297
    • Creighton, C.J.1
  • 7
    • 0036320526 scopus 로고    scopus 로고
    • Human tissue kallikreins: a family of new cancer biomarkers
    • Diamandis, E.P., Yousef, G.M., Human tissue kallikreins: a family of new cancer biomarkers. Clin. Chem. 48 (2002), 1198–1205.
    • (2002) Clin. Chem. , vol.48 , pp. 1198-1205
    • Diamandis, E.P.1    Yousef, G.M.2
  • 8
    • 84883616225 scopus 로고    scopus 로고
    • Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression
    • Eichelser, C., Flesch-Janys, D., Chang-Claude, J., Pantel, K., Schwarzenback, H., Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression. Clin. Chem. 59 (2013), 1489–1496.
    • (2013) Clin. Chem. , vol.59 , pp. 1489-1496
    • Eichelser, C.1    Flesch-Janys, D.2    Chang-Claude, J.3    Pantel, K.4    Schwarzenback, H.5
  • 10
    • 9244251607 scopus 로고    scopus 로고
    • Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells
    • Ghosh, M.C., Grass, L., Soosaipillai, A., Sotiropoulou, G., Diamandis, E.P., Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. Tumour Biol. 25 (2004), 193–199.
    • (2004) Tumour Biol. , vol.25 , pp. 193-199
    • Ghosh, M.C.1    Grass, L.2    Soosaipillai, A.3    Sotiropoulou, G.4    Diamandis, E.P.5
  • 11
    • 84888875112 scopus 로고    scopus 로고
    • SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition
    • Hahn, S., Jackstadt, R., Siemens, H., Hunten, S., Hermeking, H., SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. EMBO J. 32 (2013), 3079–3095.
    • (2013) EMBO J. , vol.32 , pp. 3079-3095
    • Hahn, S.1    Jackstadt, R.2    Siemens, H.3    Hunten, S.4    Hermeking, H.5
  • 12
    • 84866423871 scopus 로고    scopus 로고
    • MicroRNAs in the p53 network: micromanagement of tumour suppression
    • Hermeking, H., MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat. Rev. Cancer 12 (2012), 613–626.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 613-626
    • Hermeking, H.1
  • 13
    • 17144386589 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: NF-kappaB takes center stage
    • Huber, M.A., Beug, H., Wirth, T., Epithelial-mesenchymal transition: NF-kappaB takes center stage. Cell Cycle 3 (2004), 1477–1480.
    • (2004) Cell Cycle , vol.3 , pp. 1477-1480
    • Huber, M.A.1    Beug, H.2    Wirth, T.3
  • 14
    • 0032547796 scopus 로고    scopus 로고
    • Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
    • Ilic, D., Almeida, E.A., Schlaepfer, D.D., Dazin, P., Aizawa, S., Damsky, C.H., Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J. Cell. Biol. 143 (1998), 547–560.
    • (1998) J. Cell. Biol. , vol.143 , pp. 547-560
    • Ilic, D.1    Almeida, E.A.2    Schlaepfer, D.D.3    Dazin, P.4    Aizawa, S.5    Damsky, C.H.6
  • 15
    • 84871717502 scopus 로고    scopus 로고
    • Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis
    • Javeri, A., Ghaffarpour, M., Taha, M.F., Houshmand, M., Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis. Med. Oncol., 30, 2013, 413.
    • (2013) Med. Oncol. , vol.30 , pp. 413
    • Javeri, A.1    Ghaffarpour, M.2    Taha, M.F.3    Houshmand, M.4
  • 17
    • 84856347212 scopus 로고    scopus 로고
    • Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells
    • Li, J., Wang, K., Chen, X., Meng, H., Song, M., Wang, Y., Xu, X., Bai, Y., Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells. BMC Mol. Biol., 13, 2012, 4.
    • (2012) BMC Mol. Biol. , vol.13 , pp. 4
    • Li, J.1    Wang, K.2    Chen, X.3    Meng, H.4    Song, M.5    Wang, Y.6    Xu, X.7    Bai, Y.8
  • 19
    • 84874456193 scopus 로고    scopus 로고
    • A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells
    • Luo, D., Wilson, J.M., Harvel, N., Liu, J., Pei, L., Huang, S., Hawthorn, L., Shi, H., A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells. J. Transl. Med., 11, 2013, 57.
    • (2013) J. Transl. Med. , vol.11 , pp. 57
    • Luo, D.1    Wilson, J.M.2    Harvel, N.3    Liu, J.4    Pei, L.5    Huang, S.6    Hawthorn, L.7    Shi, H.8
  • 21
    • 26444457406 scopus 로고    scopus 로고
    • Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer
    • Nagahara, H., Mimori, K., Utsunomiya, T., Barnard, G.F., Ohira, M., Hirakawa, K., Mori, M., Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer. Clin. Cancer Res. 11 (2005), 6800–6806.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6800-6806
    • Nagahara, H.1    Mimori, K.2    Utsunomiya, T.3    Barnard, G.F.4    Ohira, M.5    Hirakawa, K.6    Mori, M.7
  • 22
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
    • Nakshatri, H., Bhat-Nakshari, P., Martin, D.A., Goulet, R.J. Jr., Sledge, G.W. Jr., Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 17 (1997), 3629–3639.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3629-3639
    • Nakshatri, H.1    Bhat-Nakshari, P.2    Martin, D.A.3    Goulet, R.J.4    Sledge, G.W.5
  • 26
    • 84869501780 scopus 로고    scopus 로고
    • Circulating miR-34a levels are reduced in colorectal cancer
    • Nugent, M., Miller, N., Kerin, M.J., Circulating miR-34a levels are reduced in colorectal cancer. J. Surg. Oncol. 106 (2012), 947–952.
    • (2012) J. Surg. Oncol. , vol.106 , pp. 947-952
    • Nugent, M.1    Miller, N.2    Kerin, M.J.3
  • 28
    • 33745667041 scopus 로고    scopus 로고
    • Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer
    • Pampalakis, G., Sotiropoulou, G., Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. Biol. Chem. 387 (2006), 773–782.
    • (2006) Biol. Chem. , vol.387 , pp. 773-782
    • Pampalakis, G.1    Sotiropoulou, G.2
  • 29
    • 65949090534 scopus 로고    scopus 로고
    • A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
    • Pampalakis, G., Prosnikli, E., Agalioti, T., Vlahou, A., Zoumpourlis, V., Sotiropoulou, G., A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. Cancer Res. 69 (2009), 3779–3787.
    • (2009) Cancer Res. , vol.69 , pp. 3779-3787
    • Pampalakis, G.1    Prosnikli, E.2    Agalioti, T.3    Vlahou, A.4    Zoumpourlis, V.5    Sotiropoulou, G.6
  • 31
    • 84872021010 scopus 로고    scopus 로고
    • Genomic medicine: new frontiers and new challenges
    • Pasic, M.D., Samaan, S., Yousef, G.M., Genomic medicine: new frontiers and new challenges. Clin. Chem. 59 (2013), 158–167.
    • (2013) Clin. Chem. , vol.59 , pp. 158-167
    • Pasic, M.D.1    Samaan, S.2    Yousef, G.M.3
  • 32
    • 84859849914 scopus 로고    scopus 로고
    • Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there
    • Pasic, M.D., Olkhov, E., Bapat, B., Yousef, G.M., Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there. Biol. Chem. 393 (2012), 319–330.
    • (2012) Biol. Chem. , vol.393 , pp. 319-330
    • Pasic, M.D.1    Olkhov, E.2    Bapat, B.3    Yousef, G.M.4
  • 33
    • 77951092180 scopus 로고    scopus 로고
    • Targeting of mRNAs by multiple miRNAs: the next step
    • Peter, M.E., Targeting of mRNAs by multiple miRNAs: the next step. Oncogene 29 (2010), 2161–2164.
    • (2010) Oncogene , vol.29 , pp. 2161-2164
    • Peter, M.E.1
  • 36
    • 84858606988 scopus 로고    scopus 로고
    • Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy
    • Qin, W., Zhang, K., Kliethermes, B., Ruhlen, R.L., Browne, E.P., Arcaro, K.F., Sauter, E.R., Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy. BMC Cancer, 12, 2012, 100.
    • (2012) BMC Cancer , vol.12 , pp. 100
    • Qin, W.1    Zhang, K.2    Kliethermes, B.3    Ruhlen, R.L.4    Browne, E.P.5    Arcaro, K.F.6    Sauter, E.R.7
  • 37
    • 81555216077 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: classification, prognostication, and prediction
    • Reis-Filho, J.S., Pusztai, L., Gene expression profiling in breast cancer: classification, prognostication, and prediction. Lancet 378 (2011), 1812–1823.
    • (2011) Lancet , vol.378 , pp. 1812-1823
    • Reis-Filho, J.S.1    Pusztai, L.2
  • 40
    • 84055184850 scopus 로고    scopus 로고
    • miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens, H., Jackstadt, R., Hunten, S., Kaller, M., Menssen, A., Gotz, U., Hermeking, H., miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10 (2011), 4256–4271.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3    Kaller, M.4    Menssen, A.5    Gotz, U.6    Hermeking, H.7
  • 41
    • 42049105840 scopus 로고    scopus 로고
    • Dissecting microregulation of a master regulatory network
    • Sinha, A.U., Kaimal, V., Chen, J., Jegga, A.G., Dissecting microregulation of a master regulatory network. BMC Genomics, 9, 2008, 88.
    • (2008) BMC Genomics , vol.9 , pp. 88
    • Sinha, A.U.1    Kaimal, V.2    Chen, J.3    Jegga, A.G.4
  • 44
    • 70450231593 scopus 로고    scopus 로고
    • Functional roles of human kallikrein-related peptidases
    • Sotiropoulou, G., Pampalakis, G., Diamandis, E.P., Functional roles of human kallikrein-related peptidases. J. Biol. Chem. 284 (2009), 32989–32994.
    • (2009) J. Biol. Chem. , vol.284 , pp. 32989-32994
    • Sotiropoulou, G.1    Pampalakis, G.2    Diamandis, E.P.3
  • 45
    • 67651002343 scopus 로고    scopus 로고
    • Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
    • Sotiropoulou, G., Pampalakis, G., Lianidou, E., Mourelatos, Z., Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA 15 (2009), 1443–1461.
    • (2009) RNA , vol.15 , pp. 1443-1461
    • Sotiropoulou, G.1    Pampalakis, G.2    Lianidou, E.3    Mourelatos, Z.4
  • 46
    • 84869203481 scopus 로고    scopus 로고
    • Targeting the kallikrein-related peptidases for drug development
    • Sotiropoulou, G., Pampalakis, G., Targeting the kallikrein-related peptidases for drug development. Trends Pharmacol. Sci. 33 (2012), 623–634.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 623-634
    • Sotiropoulou, G.1    Pampalakis, G.2
  • 49
    • 79954455860 scopus 로고    scopus 로고
    • Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
    • Vogt, M., Munding, J., Gruner, M., Liffers, S.T., Verdoodt, B., Hauk, J., Steinstrasser, L., Tannapfel, A., Hermeking, H., Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Arch. 458 (2011), 313–322.
    • (2011) Virchows Arch. , vol.458 , pp. 313-322
    • Vogt, M.1    Munding, J.2    Gruner, M.3    Liffers, S.T.4    Verdoodt, B.5    Hauk, J.6    Steinstrasser, L.7    Tannapfel, A.8    Hermeking, H.9
  • 50
    • 77950505077 scopus 로고    scopus 로고
    • [Expression of KLK6 protein and mRNA in primary breast cancer and its clinical significance]
    • Wang, S.M., Mao, J., Li, B., Wu, W., Tang, L.L., [Expression of KLK6 protein and mRNA in primary breast cancer and its clinical significance]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24 (2008), 1087–1089.
    • (2008) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.24 , pp. 1087-1089
    • Wang, S.M.1    Mao, J.2    Li, B.3    Wu, W.4    Tang, L.L.5
  • 51
    • 78149360436 scopus 로고    scopus 로고
    • Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor
    • Wang, F., Zheng, Z., Guo, J., Ding, X., Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor. Gynecol. Oncol. 119 (2010), 586–593.
    • (2010) Gynecol. Oncol. , vol.119 , pp. 586-593
    • Wang, F.1    Zheng, Z.2    Guo, J.3    Ding, X.4
  • 54
    • 84859880428 scopus 로고    scopus 로고
    • The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer
    • White, N.M., Youssef, Y.M., Fendler, A., Stephan, C., Jung, K., Yousef, G.M., The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer. Biol. Chem. 393 (2012), 379–389.
    • (2012) Biol. Chem. , vol.393 , pp. 379-389
    • White, N.M.1    Youssef, Y.M.2    Fendler, A.3    Stephan, C.4    Jung, K.5    Yousef, G.M.6
  • 56
    • 0036562226 scopus 로고    scopus 로고
    • Expanded human tissue kallikrein family–a novel panel of cancer biomarkers
    • Yousef, G.M., Diamandis, E.P., Expanded human tissue kallikrein family–a novel panel of cancer biomarkers. Tumour Biol. 23 (2002), 185–192.
    • (2002) Tumour Biol. , vol.23 , pp. 185-192
    • Yousef, G.M.1    Diamandis, E.P.2
  • 59
    • 33846188098 scopus 로고    scopus 로고
    • microRNAs as oncogenes and tumor suppressors
    • Zhang, B., Pan, X., Cobb, G.P., Anderson, T.A., microRNAs as oncogenes and tumor suppressors. Dev. Biol. 302 (2007), 1–12.
    • (2007) Dev. Biol. , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 60
    • 77954541671 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker
    • Zhou, H., Guo, J.M., Lou, Y.R., Zhang, X.J., Zhong, F.D., Jiang, Z., Cheng, J., Xiao, B.X., Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker. J. Mol. Med. (Berl) 88 (2010), 709–717.
    • (2010) J. Mol. Med. (Berl) , vol.88 , pp. 709-717
    • Zhou, H.1    Guo, J.M.2    Lou, Y.R.3    Zhang, X.J.4    Zhong, F.D.5    Jiang, Z.6    Cheng, J.7    Xiao, B.X.8


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