Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells

Tumor Biology

Volumn 25, Issue 4, 2004, Pages 193-199

  Ghosh, Manik C ^a   Grass, Linda ^a   Soosaipillai, Antoninus ^a   Sotiropoulou, Georgia ^c   Diamandis, Eleftherios P ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

Extracellular matrix proteins; Human kallikrein 6; Invasion; Metastasis; Serine proteases

Indexed keywords

COLLAGEN; FIBRONECTIN; GELATIN; KALLIKREIN; LAMININ; MATRIX PROTEIN; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; VITRONECTIN;

ARTICLE; CANCER INVASION; CELL MIGRATION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; TUMOR CELL; ZYMOGRAPHY;

EID: 9244251607     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081102     Document Type: Article

References (46)

1. Yousef GM, Diamandis EP: The new human tissue kallikrein gene family: Structure, function, and association to disease. Endocr Rev 2001;22:184-204.
2. Diamandis EP, Yousef GM: Human tissue kallikreins: A family of new cancer biomarkers. Clin Chem 2002;48:1198-1205.
3. Yousef GM, Diamandis EP: Expanded human tissue kallikrein family - a novel panel of cancer biomarkers. Tumour Biol 2002;23:185-192.
4. Diamandis EP, Yousef GM, Soosaipillai AR, Grass L, Porter A, Little S, Sotiropoulou G: Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications. Clin Biochem 2000;33:369-375.
5. Diamandis EP, Yousef GM, Soosaipillai AR, Bunting P: Human kallikrein 6 (zyme/protease M/neurosin): A new serum biomarker of ovarian carcinoma. Clin Biochem 2000;33:579-583.
6. Diamandis EP, Yousef GM, Petraki C, Soosaipillai AR: Human kallikrein 6 as a biomarker of Alzheimer's disease. Clin Biochem 2000;33:663-667.
7. Luo LY, Bunting P, Scorilas A, Diamandis EP: Human kallikrein 10: A novel tumor marker for ovarian carcinoma? Clin Chim Acta 2001;306:111-118.
8. Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R: A novel protease homolog differentially expressed in breast and ovarian cancer. Mol Med 1996;2:624-636.
9. Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N: Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. Biochim Biophys Acta 1997;1350:11-14.
10. Little SP, Dixon EP, Norris F, Buckley W, Becker GW, Johnson M, Dobbins JR, Wyrick T, Miller JR, MacKellar W, Hepburn D, Corvalan J, McClure D, Liu X, Stephenson D, Clemens J, Johnstone EM: Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain. J Biol Chem 1997;272:25135-25142.
11. Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP: Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. Genomics 1999;62:251-259.
12. Yousef GM, Diamandis EP: Tissue kallikreins: New players in normal and abnormal cell growth? Thromb Haemost 2003;90:7-16.
13. Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M: Activity of a newly identified serine protease in CNS demyelination. Brain 2002;125:1283-1296.
14. Petraki CD, Karavana VN, Skoufogiannis PT, Little SP, Howarth DJ, Yousef GM, Diamandis EP: The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. J Histochem Cytochem 2001;49:1431-1441.
15. Tanimoto H, Underwood LJ, Shigemasa K, Parmley TH, O'Brien TJ: Increased expression of protease M in ovarian tumors. Tumour Biol 2001;22:11-18.
16. Hoffman BR, Katsaros D, Scorilas A, Diamandis P, Fracchioli S, Rigault de la Longrais IA, Colgan T, Puopolo M, Giardina G, Massobrio M, Diamandis EP: Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: A new independent unfavourable prognostic biomarker. Br J Cancer 2002;87:763-771.
17. Ogawa K, Yamada T, Tsujioka Y, Taguchi J, Takahashi M, Tsuboi Y, Fujino Y, Nakajima M, Yamamoto T, Akatsu H, Mitsui S, Yamaguchi N: Localization of a novel type trypsinlike serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease. Psychiatry Clin Neurosci 2000;54:419-426.
18. Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP: Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. Biochem Biophys Res Commun 2003;307:948-955.
19. Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M: Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. J Biol Chem 2002;277:24562-24570.
20. Engbring JA, Kleinman HK: The basement membrane matrix in malignancy. J Pathol 2003;200:465-470.
21. Kalluri R: Basement membranes: Structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 2003;3:422-433.
22. Quondamatteo F: Assembly, stability and integrity of basement membranes in vivo. Histochem J 2002;34:369-381.
23. Hudson BG, Reeders ST, Tryggvason K: Type IV collagen: Structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. J Biol Chem 1993;268:26033-26036.
24. Colognato H, Yurchenco PD: Form and function: The laminin family of heterotrimers. Dev Dyn 2000;218:213-234.
25. Timpl R: Macromolecular organization of basement membranes. Curr Opin Cell Biol 1996;8:618-624.
26. Aaboe M, Offersen BV, Christensen A, Andreasen PA: Vitronectin in human breast carcinomas. Biochim Biophys Acta 2003;1638:72-82.
27. Kiefer JA, Farach-Carson MC: Type I collagen-mediated proliferation of PC3 prostate carcinoma cell line: Implications for enhanced growth in the bone microenvironment. Matrix Biol 2001;20:429-437.
28. Lockwood DS, Yeadon TM, Clouston AD, Crawford DG, Fawcett J, Callaghan SA, Gotley DC: Tumor progression in hepatocellular carcinoma: Relationship with tumor stroma and parenchymal disease. J Gastroenterol Hepatol 2003;18:666-672.
29. Yoon SO, Park SJ, Yun CH, Chung AS: Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J Biochem Mol Biol 2003;36:128-137.
30. Liotta LA, Stetler-Stevenson WG: Metalloproteinases and cancer invasion. Semin Cancer Biol 1990;1:99-106.
31. Diamandis EP, Christopoulos TK: The biotin-(strept)avidin system: Principles and applications in biotechnology. Clin Chem 1991;37:625-636.
32. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN: A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987;47:3239-3245.
33. Tarui T, Majumdar M, Miles LA, Ruf W, Takada Y: Plasmin-induced migration of endothelial cells. A potential target for the antiangiogenic action of angiostatin. J Biol Chem 2002;277:33564-33570.
34. Frevert CW, Wong VA, Goodman RB, Goodwin R, Martin TR: Rapid fluorescence-based measurement of neutrophil migration in vitro. J Immunol Methods 1998;213:41-52.
35. Fertala A, Han WB, Ko FK: Mapping critical sites in collagen II for rational design of gene-engineered proteins for cell-supporting materials. J Biomed Mater Res 2001;57:48-58.
36. Blacque OE, Worrall DM: Evidence for a direct interaction between the tumor suppressor serpin, maspin, and types I and III collagen. J Biol Chem 2002;277:10783-10788.
37. Kleiner DE, Stetler-Stevenson WG: Quantitative zymography: Detection of picogram quantities of gelatinases. Anal Biochem 1994;218:325-329.
38. Kleiner DE, Stetler-Stevenson WG: Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol 1999;43(suppl):S42-S51.
39. Erickson AC, Couchman JR: Still more complexity in mammalian basement membranes. J Histochem Cytochem 2000;48:1291-1306.
40. Rohrbach DH, Robinson LK, Murrah VA: Loss of the basement membrane matrix molecule, bamin, in diphenylamine-treated mice. Matrix 1993;13:341-350.
41. Cukierman E, Pankov R, Stevens DR, Yamada KM: Taking cell-matrix adhesions to the third dimension. Science 2001;294:1708-1712.
42. Nakano S, Iyama K, Ogawa M, Yoshioka H, Sado Y, Oohashi T, Ninomiya Y: Differential tissular expression and localization of type IV collagen alpha1(IV), alpha2(IV), alpha5(IV), and alpha6(IV) chains and their mRNA in normal breast and in benign and malignant breast tumors. Lab Invest 1999;79:281-292.
43. Preissner KT, Seiffert D: Role of vitronectin and its receptors in haemostasis and vascular remodeling. Thromb Res 1998:89:1-21.
44. Hintner H, Dahlback K, Dahlback B, Pepys MB, Breathnach SM: Tissue vitronectin in normal adult human dermis is non-covalently bound to elastic tissue. J Invest Dermatol 1991;96:747-753.
45. Shi Y, Kornovski BS, Savani R, Turley EA: A rapid, multiwell colorimetric assay for chemotaxis. J Immunol Methods 1993;164:149-154.
46. Bode W, Chen Z, Bartels K, Kutzbach C, Schmidt-Kastner G, Bartunik H: Refined 2 A X-ray crystal structure of porcine pancreatic kallikrein A, a specific trypsin-like serine proteinase. Crystallization, structure determination, crystallographic refinement, structure and its comparison with bovine trypsin. J Mol Biol 1983;164:237-282.