Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors

Human Molecular Genetics

Volumn 17, Issue 22, 2008, Pages 3596-3600

  Trimis, George ^a   Chatzistamou, Ioulia ^a   Politi, Katerina ^a   Kiaris, Hippokratis ^a   Papavassiliou, Athanasios G ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; SMALL INTERFERING RNA; CDKN1A PROTEIN, HUMAN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN P53; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST ADENOCARCINOMA; BREAST TUMOR; CANCER STAGING; CELL STRAIN MCF 7; CONTROLLED STUDY; FEMALE; FIBROADENOMA; FIBROBLAST; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; RISK FACTOR; STROMA; ADENOCARCINOMA; ANIMAL; CANCER TRANSPLANTATION; CHI SQUARE DISTRIBUTION; GENETICS; METABOLISM; MOUSE MUTANT; PAGET NIPPLE DISEASE; PATHOLOGY; STROMA CELL; XENOGRAFT;

MUS;

ADENOCARCINOMA; ANIMALS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CHI-SQUARE DISTRIBUTION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; RNA, SMALL INTERFERING; STROMAL CELLS; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53; VIMENTIN;

EID: 54949115518     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn252     Document Type: Article

References (15)

1. Elenbaas, B. and Weinberg, R.A. (2001) Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp. Cell Res., 264, 169-184.
2. Tlsty, T.D. and Hein, P.W. (2001) Know thy neighbor: Stromal cells can contribute oncogenic signals. Curr. Opin. Genet. Dev., 11, 54-59.
3. Olumi, A., Grossfeld, G., Hayward, S., Carroll, P., Tlsty, T. and Cunha, G. (1999) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostate epithelium. Cancer Res., 59, 5002-5011.
4. Kiaris, H., Chatzistamou, I., Kalofoutis, C., Koutselini, H., Piperi, C. and Kalofoutis, A. (2004) Tumor-stroma interactions in carcinogenesis: Basic aspects and perspectives. Mol. Cell. Biochem., 261, 117-122.
5. Kiaris, H., Chatzistamou, I., Trimis, G., Frangou-Plemmenou, M., Pafiti, A. and Kalofoutis, A. (2005) Evidence for a non-autonomous role of p53 in carcinogenesis. Cancer Res., 65, 1627-1630.
6. Hill, R., Song, Y., Cardiff, R.D. and Van Dyke, T. (2005) Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell, 123, 1001-1011.
7. Kurose, K., Gilley, K., Matsumoto, S., Watson, P.H., Zhou, X.P. and Eng, C. (2002) Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat. Genet., 32 355-357.
8. Moinfar, F., Man, Y.G., Arnould, L., Bratthauer, G.L., Ratschek, M. and Tavassoli, F.A. (2000) Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis. Cancer Res., 60, 2562-2566.
9. Patocs, A., Zhang, L., Xu, Y.,Weber, F., Caldes, T., Mutter, G.L., Platzer, P. and Eng, C. (2007) Breast-cancer stromal cells with TP53 mutations and nodal metastases. N. Engl. J. Med., 357, 2543-2551.
10. el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. and Vogelstein, B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
11. Weiss, R.H. (2003) p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell, 4, 425-429.
12. Brugarolas, J., Chandrasekaran, C., Gordon, J.I., Beach, D., Jacks, T. and Hannon, G.J. (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature, 377, 552-527.
13. Kuperwasser, C., Chavarria, T., Wu,M., Magrane, G., Gray, J.W., Carey, L., Richardson, A. and Weinberg, R.A. (2004) Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl Acad. Sci. USA, 101, 4966-4971.
14. Thor, A.D., Liu, S., Moore, D.H., 2nd and Edgertom, S.M. (1999) Comparison of mitotic index, in vitro bromodeoxyuridine labeling, and MIB-1 assays to quantitate proliferation in breast cancer. J. Clin. Oncol., 17, 470-477.
15. Lafkas, D., Trimis, G., Papavassiliou, A.G. and Kiaris, H. (2008) p53 mutations in stromal fibroblasts sensitize tumors against chemotherapy. Int. J. Cancer, 123, 967-971.