An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis

Carcinogenesis

Volumn 37, Issue 4, 2015, Pages 385-396

  Ahmed, Ishfaq ^a   Roy, Badal C ^a   Subramaniam, Dharmalingam ^a   Ganie, Showkat Ahmad ^b   Kwatra, Deep ^c   Dixon, Dan ^d   Anant, Shrikant ^a,d   Zargar, Mohammad Afzal ^b   Umar, Shahid ^a,d  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KASHMIR   (India)

^c US Food and Administration   (United States)

^d UNIVERSITY OF KANSAS CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCEA ROSEA EXTRACT; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ANTINEOPLASTIC AGENT; CYCLIN A2; CYCLIN B; CYCLIN D1; DOUBLE CORTIN LIKE KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOTRANSFERASE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL XL; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CANCER SURVIVAL; CELL PROLIFERATION; CELL SELF-RENEWAL; COLON CARCINOGENESIS; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG PURIFICATION; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HCT116 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; ORNAMENTAL PLANT; PLANT SEED; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING; WNT SIGNALING PATHWAY; COLON TUMOR; GENETIC EPIGENESIS; PATHOLOGY; PLANT; SIGNAL TRANSDUCTION;

COLONIC NEOPLASMS; EPIGENESIS, GENETIC; HUMANS; NEOPLASTIC STEM CELLS; PLANTS; SIGNAL TRANSDUCTION;

EID: 84963548990     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgw009     Document Type: Article

References (49)

1. Siegel, R. et al. (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA. Cancer J. Clin., 61, 212-236.
2. Thomassen, I. et al. (2013) Incidence, prognosis, and treatment options for patients with synchronous peritoneal carcinomatosis and liver metastases from colorectal origin. Dis. Colon Rectum, 56, 1373-1380.
3. Chung, K.Y. et al. (2007) Adjuvant therapy of colon cancer: current status and future directions. Cancer J., 13, 192-197.
4. Fearon, E.R. et al. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
5. Burn, J. et al. (2011) Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet, 378, 2081-2087.
6. Louis, P. et al. (2014) The gut microbiota, bacterial metabolites and colorectal cancer. Nat. Rev. Microbiol., 12, 661-672.
7. Boman, B.M. et al. (2008) Cancer stem cells: a step toward the cure. J. Clin. Oncol., 26, 2795-2799.
8. Khalek, F.J.A. et al. (2010) Colon cancer stem cells. Gastrointest. Cancer Res., S16-S23.
9. Boquoi, A. (2014) Bidirectional conversion of intestinal epithelial cells: NF?B is key. Cancer Biol. Ther., 15, 170-171.
10. Li, L. et al. (2013) Doublecortin-like kinase 1 exhibits cancer stem celllike characteristics in a human colon cancer cell line. Chin. J. Cancer Res., 25, 134-142.
11. Groden, J. et al. (1995) Response of colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene. Cancer Res., 55, 1531-1539.
12. Sikandar, S.S. et al. (2010) NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res., 70, 1469-1478.
13. Andre, T. et al. (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. New Engl. J. Med., 350, 2343-2351.
14. Clarke, M.F. et al. (2006) Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res., 66, 9339-9344.
15. Ahmadi, M. et al. (2012) Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats. Indian J. Pharmacol., 44, 304-307.
16. Landegren, U. (1984) Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. J. Immunol. Methods, 67, 379-388.
17. van Engeland, M. et al. (1996) A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry, 24, 131-139.
18. Franken, N.A. et al. (2006) Clonogenic assay of cells in vitro. Nat. Protoc., 1, 2315-2319.
19. Kim, Y. et al. (2009) Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res., 69, 9271-9280.
20. Hemmati, H.D. et al. (2003) Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl. Acad. Sci. USA, 100, 15178-15183.
21. Rao, C., et al. (2013). Crosstalk between canonical TGF-beta/Smad and Wnt/beta-catenin signaling pathway. Zhejiang Da Xue Xue Bao Yi Xue Ban, 42, 591-596.
22. Ahmed, I. et al. (2012) Critical roles of Notch and Wnt/ß-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection. Infect. Immun., 80, 3107-3121.
23. Gopalakrishnan, N. et al. (2014) Colocalization of ß-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation. Mol. Cell. Biochem., 396, 281-293.
24. Umar, S. (2010). Intestinal stem cells. Curr Gastroenterol Reports, 12, 340-348.
25. Roy, B.C. et al. (2015) Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2. Oncogene, 34, 4519-4530.
26. Arlt, F. et al. (2009) Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. Int. J. Biochem. Cell Biol., 41, 2356-2359.
27. Greiner, A.K. et al. (2014) Chemoprevention in gastrointestinal physiology and disease. Natural products and microbiome. Am. J. Physiol. Gastrointest. Liver Physiol., 307, G1-15.
28. Huerta, S. et al. (2006) Colon cancer and apoptosis. Am. J. Surg., 191, 517-526.
29. Yang, S.Y. et al. (2009) Apoptosis and colorectal cancer: implications for therapy. Trends Mol. Med., 15, 225-233.
30. Liu, S. et al. (2005) Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res., 7, 86-95.
31. Bush, B.M. et al. (2013) The Wnt/ß-catenin/T-cell factor 4 pathway upregulates high-mobility group A1 expression in colon cancer. Cell Biochem. Funct., 31, 228-236.
32. Jingushi, K. et al. (2012) DIF-1 inhibits the Wnt/ß-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines. Biochem. Pharmacol., 83, 47-56.
33. Scholer-Dahirel, A. et al. (2012) Determinants of Wnt/beta-catenin pathway dependency in colorectal cancer. Cell Cycle, 11, 9-10.
34. Zhang, X. et al. (2011) Curcumin activates Wnt/beta-catenin signaling pathway through inhibiting the activity of GSK-3beta in APPswe transfected SY5Y cells. Eur. J. Pharm. Sci., 42, 540-546.
35. Chen, H.J. et al. (2012) The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway. Biochem. Pharmacol., 84, 1143-1153.
36. Kanwar, S.S. et al. (2010) The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol. Cancer, 9, 212.
37. Dalerba, P. et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. USA, 104, 10158-10163.
38. Ryu, M.J. et al. (2008) Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem. Biophys. Res. Commun., 377, 1304-1308.
39. Li, Y. et al. (2010) Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin. Cancer Res., 16, 2580-2590.
40. Min, S.J. et al. (2015) Sasa quelpaertensis leaf extract inhibits colon cancer by regulating cancer cell stemness in vitro and in vivo. Int. J. Mol. Sci., 16, 9976-9997.
41. Fender, A.W. et al. (2015). Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer. J. Cell. Biochem., 116, 2517-2527.
42. Suman, S. et al. (2014) Targeting Notch signaling in colorectal cancer. Curr. Colorectal Cancer Rep., 10, 411-416.
43. Ponnurangam, S. et al. (2012) Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells. Mol. Cancer Ther., 11, 963-972.
44. Cecchinato, V. et al. (2007) Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells. Biochem. Pharmacol., 74, 1568-1574.
45. Li, Y. et al. (2012) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. FEBS J., 279, 2247-2259.
46. Hahm, E.R. et al. (2012) Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration. PLoS One, 7, e44957.
47. Pan, H. et al. (2012) Genistein inhibits MDA-MB-231 triple-negative breast cancer cell growth by inhibiting NF-?B activity via the Notch-1 pathway. Int. J. Mol. Med., 30, 337-343.
48. Subramaniam, D. et al. (2014) DNA methyltransferases: a novel target for prevention and therapy. Front. Oncol., 4, 80.
49. Jung, H.Y. et al. (2013) PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation. Mol. Cell, 52, 193-205.