TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth

Cell Cycle

Volumn 15, Issue 7, 2016, Pages 931-947

  Pavlides, Savvas C ^a   Lecanda, Jon ^a   Daubriac, Julien ^a   Pandya, Unnati M ^a   Gama, Patricia ^b   Blank, Stephanie ^a   Mittal, Khushbakhat ^a   Shukla, Pratibha ^a   Gold, Leslie I ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

APC CCdh1; cell cycle; E3 ligase; endometrial cancer; endometrium; growth regulation; p27kip1; SCF Skp2 Cks1; TGF ; ubiquitin proteasome system

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASES REGULATORY SUBUNIT 1; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; UVOMORULIN; CKS1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FIZZY RELATED PROTEIN; PROTEASOME; S PHASE KINASE ASSOCIATED PROTEIN;

ARTICLE; CANCER CELL LINE; CELL CYCLE ARREST; CELL LOSS; CELL PROLIFERATION; ENDOMETRIUM; ENDOMETRIUM CANCER; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE TARGETING; GROWTH REGULATION; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE GROWTH; BIOSYNTHESIS; CELL CYCLE CHECKPOINT; CELL NUCLEUS; ENDOMETRIUM TUMOR; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANAPHASE-PROMOTING COMPLEX-CYCLOSOME; CDC2-CDC28 KINASES; CDH1 PROTEINS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; EPITHELIAL CELLS; FEMALE; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; S-PHASE KINASE-ASSOCIATED PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84963500018     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2016.1150393     Document Type: Article

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