Drug-induced liver injury classification model based on in vitro human transcriptomics and in vivo rat clinical chemistry data

Systems Biomedicine

Volumn 2, Issue 4, 2015, Pages 63-70

  Jennen, Danyel ^a   Polman, Jan ^a   Bessem, Mark ^a   Coonen, Maarten ^a   van Delft, Joost ^a   Kleinjans, Jos ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

CAMDA Challenge 2013; Clinical chemistry; DILI; Prediction model; Primary human hepatocytes; Transcriptomics

Indexed keywords

ACARBOSE; ACETAZOLAMIDE; ALLOPURINOL; AMIODARONE; BENDAZAC; BENZBROMARONE; CAFFEINE; CHLORAMPHENICOL; CHLORMEZANONE; CHLORPHENIRAMINE; CIPROFLOXACIN; CLOMIPRAMINE; CYCLOSPORIN A; DILTIAZEM; ETHAMBUTOL; FLUTAMIDE; HYDROXYZINE; INDOMETACIN; IPRONIAZID; LABETALOL; METFORMIN; PARACETAMOL; PEMOLINE; PROPYLTHIOURACIL; RIFAMPICIN; TACRINE; THIAMAZOLE; TICLOPIDINE; TRIMETHADIONE; UNINDEXED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLINICAL CHEMISTRY; CONTROLLED STUDY; DRUG LABELING; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER CELL; NONHUMAN; PREDICTION; RAT; TOXIC HEPATITIS; TRANSCRIPTOMICS; VALIDATION STUDY;

EID: 84962955865     PISSN: 21628130     EISSN: 21628149     Source Type: Journal    
DOI: 10.4161/sysb.29400     Document Type: Article

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