Optimization of genome shuffling for high-yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants

Applied Microbiology and Biotechnology

Volumn 100, Issue 17, 2016, Pages 7491-7498

  Wang, Mingzi ^a   Zhang, Wei ^b   Xu, Weikai ^c   Shen, Yuemao ^c   Du, Liangcheng ^d  

^a FUJIAN NORMAL UNIVERSITY   (China)

^b QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

^c XIAMEN UNIVERSITY   (China)

^d UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Fungal endophyte; Genome shuffling; Natural product; Phomopsis sp; Simulation

Indexed keywords

DRUG PRODUCTS; GENES; INTELLIGENT SYSTEMS; PLANTS (BOTANY);

FUNGAL ENDOPHYTES; GENOME SHUFFLING; NATURAL PRODUCTS; PHOMOPSIS SP; SIMULATION;

MONTE CARLO METHODS;

ANTINEOPLASTIC AGENT; DEACETYLMYCOEPOXYDIENE; NATURAL PRODUCT; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; FUSED HETEROCYCLIC RINGS; PYRONE DERIVATIVE;

BIOLOGICAL PRODUCTION; CHEMICAL COMPOUND; ENDOPHYTE; ENZYME; FUNGUS; GENETIC ENGINEERING; GENOME; MANGROVE; MONTE CARLO ANALYSIS; OPTIMIZATION; SIMULATION; TUMOR;

ARTICLE; CELL FUSION; DRUG SCREENING; DRUG STRUCTURE; ENDOPHYTE; ENDOPHYTIC FUNGUS; FUNGAL STRAIN; GENOME; GENOME SHUFFLING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MANGROVE; MONTE CARLO METHOD; NONHUMAN; PHOMOPSIS; PROCESS OPTIMIZATION; PROTOPLAST; SIMULATION; ASCOMYCETES; DNA SHUFFLING; FUNGAL GENOME; GENETICS; METABOLISM; MICROBIOLOGY; PROCEDURES; RHIZOPHORACEAE;

FUNGI; PHOMOPSIS;

ANTINEOPLASTIC AGENTS; ASCOMYCOTA; BIOLOGICAL PRODUCTS; BRIDGED BICYCLO COMPOUNDS, HETEROCYCLIC; CELL FUSION; DNA SHUFFLING; ENDOPHYTES; GENOME, FUNGAL; MONTE CARLO METHOD; PYRONES; RHIZOPHORACEAE;

EID: 84962920891     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-016-7457-0     Document Type: Article

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