Increased retinal expression of the pro-angiogenic receptor GPR91 via BMP6 in a mouse model of juvenile hemochromatosis

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 4, 2016, Pages 1612-1619

  Arjunan, Pachiappan ^a,b   Gnanaprakasam, Jaya P ^a   Ananth, Sudha ^a   Romej, Michelle A ^a   Rajalakshmi, Veeranan Karmegam ^a   Prasad, Puttur D ^a   Martin, Pamela M ^a   Gurusamy, Mariappan ^a   Thangaraju, Muthusamy ^a   Bhutia, Yangzom D ^a,c   Ganapathy, Vadivel ^a,c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b AUGUSTA UNIVERSITY   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Age related macular degeneration; BMP6 signaling; Juvenile hemochromatosis; Retinal pigment epithelium; Succinate receptor GPR91

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 91; HEMOJUVELIN; SMAD PROTEIN; SMAD4 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; BMP6 PROTEIN, MOUSE; GPR91 PROTEIN, MOUSE; RNA;

ADOLESCENT; ANGIOGENESIS; ANGIOMA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; GENE MUTATION; GENE TARGETING; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IRON METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CELL LINE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; INDIRECT FLUORESCENT ANTIBODY TECHNIQUE; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; RETINA; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 6; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HUMANS; MICE; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; RETINA; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84962885890     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-17437     Document Type: Article

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