메뉴 건너뛰기




Volumn 55, Issue 6, 2014, Pages 3616-3625

Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis

Author keywords

Angiogenesis; Gliosis; Iron; Retinal vasculature

Indexed keywords

CD11B ANTIGEN; COLLAGEN TYPE 4; ENDOGLIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOPROTEIN P 15095; HEMOJUVELIN; IRON REGULATORY FACTOR; ISOLECTIN B4; TRYPSIN; VASCULOTROPIN; VIMENTIN;

EID: 84902449592     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13677     Document Type: Article
Times cited : (13)

References (50)
  • 1
    • 80052655782 scopus 로고    scopus 로고
    • The molecular pathogenesis of hereditary hemochromatosis
    • Babitt JL, Lin HY. The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis. 2011;31:280-292.
    • (2011) Semin Liver Dis. , vol.31 , pp. 280-292
    • Babitt, J.L.1    Lin, H.Y.2
  • 3
    • 78751578860 scopus 로고    scopus 로고
    • The molecular basis of iron overload disorders and iron-linked anemias
    • Kaplan J, Ward DM, De Domenico I. The molecular basis of iron overload disorders and iron-linked anemias. Int J Hematol. 2011;93:14-20.
    • (2011) Int J Hematol. , vol.93 , pp. 14-20
    • Kaplan, J.1    Ward, D.M.2    De Domenico, I.3
  • 4
    • 84861355868 scopus 로고    scopus 로고
    • Hepcidin and iron homeostasis
    • Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012;1823:1434-1443.
    • (2012) Biochim Biophys Acta. , vol.1823 , pp. 1434-1443
    • Ganz, T.1    Nemeth, E.2
  • 5
    • 70450209180 scopus 로고    scopus 로고
    • Absence of ironregulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: Role of cystine/glutamate exchanger
    • Gnana-Prakasam JP, Thangaraju M, Liu K, et al. Absence of ironregulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. Biochem J. 2009;424:243-252.
    • (2009) Biochem J. , vol.424 , pp. 243-252
    • Gnana-Prakasam, J.P.1    Thangaraju, M.2    Liu, K.3
  • 6
    • 80051748543 scopus 로고    scopus 로고
    • Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium
    • Gnana-Prakasam JP, Ananth S, Prasad PD, et al. Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011; 52:3751-3758.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 3751-3758
    • Gnana-Prakasam, J.P.1    Ananth, S.2    Prasad, P.D.3
  • 7
    • 84555187432 scopus 로고    scopus 로고
    • Iron-mediated retinal degeneration in hemojuvelin knockout mice
    • Gnana-Prakasam J, Tawfik A, Romej M, et al. Iron-mediated retinal degeneration in hemojuvelin knockout mice. Biochem J. 2012;441:599-608.
    • (2012) Biochem J. , vol.441 , pp. 599-608
    • Gnana-Prakasam, J.1    Tawfik, A.2    Romej, M.3
  • 9
    • 84863697879 scopus 로고    scopus 로고
    • Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis
    • Gnana-Prakasam JP, Reddy SK, Veeranan-Karmegam R, Smith SB, Martin PM, Ganapathy V. Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. Invest Ophthalmol Vis Sci. 2011;52:9279-9286.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 9279-9286
    • Gnana-Prakasam, J.P.1    Reddy, S.K.2    Veeranan-Karmegam, R.3    Smith, S.B.4    Martin, P.M.5    Ganapathy, V.6
  • 10
    • 79952227908 scopus 로고    scopus 로고
    • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice
    • Hadziahmetovic M, Song Y, Ponnuru P, et al. Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci. 2011;52:109-118.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 109-118
    • Hadziahmetovic, M.1    Song, Y.2    Ponnuru, P.3
  • 11
    • 79953272637 scopus 로고    scopus 로고
    • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration
    • Hadziahmetovic M, Song Y, Wolkow N, et al. The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2011;52:959-968.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 959-968
    • Hadziahmetovic, M.1    Song, Y.2    Wolkow, N.3
  • 12
    • 80052472676 scopus 로고    scopus 로고
    • Bmp6 regulates retinal iron homeostasis and has altered expression in agerelated macular degeneration
    • Hadziahmetovic M, Song Y, Wolkow N, et al. Bmp6 regulates retinal iron homeostasis and has altered expression in agerelated macular degeneration. Am J Pathol. 2011;179:335-348.
    • (2011) Am J Pathol. , vol.179 , pp. 335-348
    • Hadziahmetovic, M.1    Song, Y.2    Wolkow, N.3
  • 14
    • 35348944706 scopus 로고    scopus 로고
    • Iron homeostasis and toxicity in retinal degeneration
    • He X, Hahn P, Iacovelli J, et al. Iron homeostasis and toxicity in retinal degeneration. Prog Retin Eye Res. 2007;26:649-673.
    • (2007) Prog Retin Eye Res. , vol.26 , pp. 649-673
    • He, X.1    Hahn, P.2    Iacovelli, J.3
  • 15
    • 84883495401 scopus 로고    scopus 로고
    • Retinal iron homeostasis in health and disease
    • Song D, Dunaief JL. Retinal iron homeostasis in health and disease. Front Aging Neurosci. 2013;5:24.
    • (2013) Front Aging Neurosci. , vol.5 , pp. 24
    • Song, D.1    Dunaief, J.L.2
  • 16
    • 34247143301 scopus 로고    scopus 로고
    • Iron induced oxidative damage as a potential factor in age-related macular degeneration: The Cogan Lecture
    • Dunaief JL. Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture. Invest Ophthalmol Vis Sci. 2006;47:4660-4664.
    • (2006) Invest Ophthalmol Vis Sci. , vol.47 , pp. 4660-4664
    • Dunaief, J.L.1
  • 18
    • 79955038329 scopus 로고    scopus 로고
    • Implications of altered iron homeostasis for age-related macular degeneration
    • Blasiak J, Szaflik J, Szaflik JP. Implications of altered iron homeostasis for age-related macular degeneration. Front Biosci. 2011;16:1551-1559.
    • (2011) Front Biosci. , vol.16 , pp. 1551-1559
    • Blasiak, J.1    Szaflik, J.2    Szaflik, J.P.3
  • 19
    • 79952112946 scopus 로고    scopus 로고
    • Iron overload in diabetic retinopathy: A cause or a consequence of impaired mechanisms?
    • 2010. pii: 714108
    • Ciudin A, Hernandez C, Simo R. Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms? Exp Diabetes Res. 2010;2010. pii: 714108.
    • (2010) Exp Diabetes Res.
    • Ciudin, A.1    Hernandez, C.2    Simo, R.3
  • 24
    • 43749096100 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration: Potential therapies
    • Chappelow AV, Kaiser PK. Neovascular age-related macular degeneration: potential therapies. Drugs. 2008;68:1029-1036.
    • (2008) Drugs. , vol.68 , pp. 1029-1036
    • Chappelow, A.V.1    Kaiser, P.K.2
  • 25
    • 84863727273 scopus 로고    scopus 로고
    • Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/ retinal pigment epithelium/Bruch's membrane/choriocapillaris complex
    • Bhutto I, Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/ retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol Aspects Med. 2012;33:295-317.
    • (2012) Mol Aspects Med. , vol.33 , pp. 295-317
    • Bhutto, I.1    Lutty, G.2
  • 26
    • 0031019612 scopus 로고    scopus 로고
    • Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGEinfused rats
    • Stitt AW, Li YM, Gardiner TA, Bucala R, Archer DB, Vlassara H. Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGEinfused rats. Am J Pathol. 1997;150:523-531.
    • (1997) Am J Pathol. , vol.150 , pp. 523-531
    • Stitt, A.W.1    Li, Y.M.2    Gardiner, T.A.3    Bucala, R.4    Archer, D.B.5    Vlassara, H.6
  • 27
    • 84873371829 scopus 로고    scopus 로고
    • Alterations of retinal vasculature in cystathionine-β-synthase mutant mice, a model of hyperhomocysteinemia
    • Tawfik A, Al-Shabrawey M, Roon P, et al. Alterations of retinal vasculature in cystathionine-β-synthase mutant mice, a model of hyperhomocysteinemia. Invest Ophthalmol Vis Sci. 2013; 54:939-949.
    • (2013) Invest Ophthalmol Vis Sci. , vol.54 , pp. 939-949
    • Tawfik, A.1    Al-Shabrawey, M.2    Roon, P.3
  • 28
    • 77953253715 scopus 로고    scopus 로고
    • Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/ beta-catenin signaling pathway and uPAR expression
    • Yang J, Duh EJ, Caldwell RB, Behzadian MA. Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/ beta-catenin signaling pathway and uPAR expression. Invest Ophthalmol Vis Sci. 2010;51:3273-3280.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 3273-3280
    • Yang, J.1    Duh, E.J.2    Caldwell, R.B.3    Behzadian, M.A.4
  • 29
    • 0346251249 scopus 로고    scopus 로고
    • Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies
    • Fonsatti E, Sigalotti L, Arslan P, Altomonte M, Maio M. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies. Curr Cancer Drug Targets. 2003;3:427-432.
    • (2003) Curr Cancer Drug Targets. , vol.3 , pp. 427-432
    • Fonsatti, E.1    Sigalotti, L.2    Arslan, P.3    Altomonte, M.4    Maio, M.5
  • 31
    • 0028136393 scopus 로고
    • Collagen type IV gene expression in human optic nerve heads with primary open angle glaucoma
    • Hernandez MR, Ye H, Roy S. Collagen type IV gene expression in human optic nerve heads with primary open angle glaucoma. Exp Eye Res. 1994;59:41-51.
    • (1994) Exp Eye Res. , vol.59 , pp. 41-51
    • Hernandez, M.R.1    Ye, H.2    Roy, S.3
  • 32
    • 79958000149 scopus 로고    scopus 로고
    • Immunohistochemical analysis of TIMP-2 and collagen types I and IV in experimental spinal cord ischemia-reperfusion injury in rats
    • Anik I, Kokturk S, Genc H, et al. Immunohistochemical analysis of TIMP-2 and collagen types I and IV in experimental spinal cord ischemia-reperfusion injury in rats. Spinal Cord Med. 2011;34:257-264.
    • (2011) Spinal Cord Med. , vol.34 , pp. 257-264
    • Anik, I.1    Kokturk, S.2    Genc, H.3
  • 33
    • 84872021668 scopus 로고    scopus 로고
    • Vascular endothelial growth factor a in intraocular vascular disease
    • Miller JW, Le Couter J, Strauss EC, Ferrara N. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology. 2013;120:106-114.
    • (2013) Ophthalmology. , vol.120 , pp. 106-114
    • Miller, J.W.1    Le Couter, J.2    Strauss, E.C.3    Ferrara, N.4
  • 34
    • 0344736812 scopus 로고    scopus 로고
    • Up-regulation of glial fibrillary acidic protein in response to retinal injury: Its potential role in glial remodeling and a comparison to vimentin expression
    • Lewis GP, Fisher SK. Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int Rev Cytol. 2003;230:263-290.
    • (2003) Int Rev Cytol. , vol.230 , pp. 263-290
    • Lewis, G.P.1    Fisher, S.K.2
  • 35
    • 33947308813 scopus 로고    scopus 로고
    • Vascular permeability in ocular disease and the role of tight junctions
    • Erickson KK, Sundstrom JM, Antonetti DA. Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis. 2007;10:103-117.
    • (2007) Angiogenesis. , vol.10 , pp. 103-117
    • Erickson, K.K.1    Sundstrom, J.M.2    Antonetti, D.A.3
  • 36
    • 84892657750 scopus 로고    scopus 로고
    • The liver: Conductor of systemic iron regulation
    • Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron regulation. Blood. 2014;123:168-176.
    • (2014) Blood. , vol.123 , pp. 168-176
    • Meynard, D.1    Babitt, J.L.2    Lin, H.Y.3
  • 37
    • 41649120714 scopus 로고    scopus 로고
    • Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe
    • Gnana-Prakasam JP, Martin PM, Mysona BA, Roon P, Smith SB, Ganapathy V. Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. Biochem J. 2008;411:79-88.
    • (2008) Biochem J. , vol.411 , pp. 79-88
    • Gnana-Prakasam, J.P.1    Martin, P.M.2    Mysona, B.A.3    Roon, P.4    Smith, S.B.5    Ganapathy, V.6
  • 39
    • 70649085074 scopus 로고    scopus 로고
    • HIF prolyl 4-hydroxylases and their potential as drug targets
    • Myllyharju J. HIF prolyl 4-hydroxylases and their potential as drug targets. Curr Pharm Des. 2009;15:3878-3885.
    • (2009) Curr Pharm Des. , vol.15 , pp. 3878-3885
    • Myllyharju, J.1
  • 40
    • 19044392200 scopus 로고    scopus 로고
    • Ascorbate depletion: A critical step in nickel carcinogenesis?
    • Salnikow K, Kasprzak KS. Ascorbate depletion: a critical step in nickel carcinogenesis? Environ Health Perspect. 2005;113: 577-584.
    • (2005) Environ Health Perspect. , vol.113 , pp. 577-584
    • Salnikow, K.1    Kasprzak, K.S.2
  • 41
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
    • Kim TH, Hur EG, Kang SJ, et al. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res. 2011;71:2260-2275.
    • (2011) Cancer Res. , vol.71 , pp. 2260-2275
    • Kim, T.H.1    Hur, E.G.2    Kang, S.J.3
  • 42
    • 84896330751 scopus 로고    scopus 로고
    • Heme oxygenase-1 is required for angiogenic function of bone marrow-derived progenitor cells: Role in therapeutic revascularization
    • Grochot-Przeczek A, Kotlinowski J, Kozakowska M, et al. Heme oxygenase-1 is required for angiogenic function of bone marrow-derived progenitor cells: role in therapeutic revascularization. Antioxid Redox Signal. 2014;20:1677-1692.
    • (2014) Antioxid Redox Signal. , vol.20 , pp. 1677-1692
    • Grochot-Przeczek, A.1    Kotlinowski, J.2    Kozakowska, M.3
  • 43
    • 38049132217 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesis
    • Dulak J, Deshane J, Jozkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: focus on angiogenesis. Circulation. 2008;117:231-241.
    • (2008) Circulation. , vol.117 , pp. 231-241
    • Dulak, J.1    Deshane, J.2    Jozkowicz, A.3    Agarwal, A.4
  • 44
    • 27144544180 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5
    • McCrae KR, Donate F, Merkulov S, Sun D, Qi X, Shaw DE. Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5. Curr Cancer Drug Targets. 2005;5:519-528.
    • (2005) Curr Cancer Drug Targets. , vol.5 , pp. 519-528
    • McCrae, K.R.1    Donate, F.2    Merkulov, S.3    Sun, D.4    Qi, X.5    Shaw, D.E.6
  • 46
    • 53549118277 scopus 로고    scopus 로고
    • The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
    • Sapieha P, Sirinyan M, Hamel D, et al. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med. 2008;14:1067-1076.
    • (2008) Nat Med. , vol.14 , pp. 1067-1076
    • Sapieha, P.1    Sirinyan, M.2    Hamel, D.3
  • 49
    • 84880805871 scopus 로고    scopus 로고
    • Matriptase-2, a regulatory protease of iron homeostasis: Possible substrates, cleavage sites, and inhibitors
    • Stirnberg M, Gutschow M. Matriptase-2, a regulatory protease of iron homeostasis: possible substrates, cleavage sites, and inhibitors. Curr Pharm Des. 2013;19:1052-1061.
    • (2013) Curr Pharm Des. , vol.19 , pp. 1052-1061
    • Stirnberg, M.1    Gutschow, M.2
  • 50
    • 4644293303 scopus 로고    scopus 로고
    • Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
    • Hahn P, Qian Y, Dentchev T, et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2004;101:13850-13855.
    • (2004) Invest Ophthalmol Vis Sci. , vol.101 , pp. 13850-13855
    • Hahn, P.1    Qian, Y.2    Dentchev, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.