Risk Factors for Hip Fracture in Older Men: The Osteoporotic Fractures in Men Study (MrOS)

Journal of Bone and Mineral Research

Volumn 31, Issue 10, 2016, Pages 1810-1819

  Cauley, Jane A ^a   Cawthon, Peggy M ^b,c   Peters, Katherine E ^b   Cummings, Steven R ^b,c   Ensrud, Kristine E ^d,e,f   Bauer, Douglas C ^c   Taylor, Brent C ^d,e,f   Shikany, James M ^g   Hoffman, Andrew R ^h   Lane, Nancy E ⁱ   Kado, Deborah M ^j   Stefanick, Marcia L ^h   Orwoll, Eric S ^k  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^h STANFORD UNIVERSITY   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BONE DENSITY; COMORBIDITY ASSESSMENT; CONTROLLED STUDY; DEPRESSION; EXERCISE; FEMALE; FOLLOW UP; FOOD FREQUENCY QUESTIONNAIRE; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; HYPERTHYROIDISM; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PUBLIC HEALTH; RISK ASSESSMENT; RISK FACTOR; ANGINA PECTORIS; CLINICAL TRIAL; COMPLICATION; HEART INFARCTION; MORTALITY; MULTICENTER STUDY; PARKINSON DISEASE; PROPORTIONAL HAZARDS MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANGINA PECTORIS; FOLLOW-UP STUDIES; HIP FRACTURES; HUMANS; HYPERTHYROIDISM; MALE; MYOCARDIAL INFARCTION; OSTEOPOROSIS; PARKINSON DISEASE; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84962875862     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2836     Document Type: Article

References (67)

1. Cauley JA. Public health impact of osteoporosis. J Gerontol A Biol Sci Med Sci. 2013; 68(10):1243–51.
2. Khosla S, Amin S, Orwoll E. Osteoporosis in men. Endocr Rev. 2008; 29(4):441–64.
3. Fransen M, Woodward M, Norton R, Robinson E, Butler M, Campbell AJ. Excess mortality or institutionalization after hip fracture: men are at greater risk than women. J Am Geriatr Soc. 2002; 50(4):685–90.
4. Wright NC, Saag KG, Curtis JR, et al. Recent trends in hip fracture rates by race/ethnicity among older US adults. J Bone Miner Res. 2012; 27(11):2325–32.
5. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1995; 332(12):767–73.
6. De Laet CE, Van Hout BA, Burger H, Weel AE, Hofman A, Pols HA. Hip fracture prediction in elderly men and women: validation in the Rotterdam study. J Bone Miner Res. 1998; 13(10):1587–93.
7. Johnell O, Kanis JA, Oden A, et al. Predictive value of BMD for hip and other fractures. J Bone Miner Res. 2005; 20(7):1185–94.
8. Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004; 34(1):195–202.
9. Cawthon PM, Fullman RL, Marshall L, et al. Physical performance and risk of hip fractures in older men. J Bone Miner Res. 2008; 23(7):1037–44.
10. Kauppi M, Stenholm S, Impivaara O, Maki J, Heliovaara M, Jula A. Fall-related risk factors and heel quantitative ultrasound in the assessment of hip fracture risk: a 10-year follow-up of a nationally representative adult population sample. Osteoporos Int. 2014; 25(6):1685–95.
11. Mussolino ME, Looker AC, Madans JH, Langlois JA, Orwoll ES. Risk factors for hip fracture in white men: the NHANES I Epidemiologic Follow-up Study. J Bone Miner Res. 1998; 13(6):918–24.
12. Kanis J, Johnell O, Gullberg B, et al. Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean Osteoporosis Study. Osteoporos Int. 1999; 9(1):45–54.
13. Schwartz AV, Kelsey JL, Sidney S, Grisso JA. Characteristics of falls and risk of hip fracture in elderly men. Osteoporos Int. 1998; 8(3):240–6.
14. Grisso JA, Kelsey JL, O'Brien LA, et al. Risk factors for hip fracture in men. Hip Fracture Study Group. Am J Epidemiol. 1997; 145(9):786–93.
15. Nguyen ND, Pongchaiyakul C, Center JR, Eisman JA, Nguyen TV. Identification of high-risk individuals for hip fracture: a 14-year prospective study. J Bone Miner Res. 2005; 20(11):1921–8.
16. Michaelsson K, Wolk A, Langenskiold S, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ. 2014; 349:g6015.
17. Feskanich D, Flint AJ, Willett WC. Physical activity and inactivity and risk of hip fractures in men. Am J Public Health. 2014; 104(4):e75–81.
18. Feskanich D, Owusu W, Hunter DJ, et al. Use of toenail fluoride levels as an indicator for the risk of hip and forearm fractures in women. Epidemiology. 1998; 9(4):412–6.
19. Benetou V, Orfanos P, Feskanich D, et al. Education, marital status, and risk of hip fractures in older men and women: the CHANCES project. Osteoporos Int. 2015; 26(6):1733–46.
20. Feskanich D, Bischoff-Ferrari HA, Frazier AL, Willett WC. Milk consumption during teenage years and risk of hip fractures in older adults. JAMA Pediatr. 2014; 168(1):54–60.
21. Orwoll E, Blank JB, Barrett-Connor E, et al. Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study—a large observational study of the determinants of fracture in older men. Contemp Clin Trials. 2005; 26(5):569–85.
22. Blank JB, Cawthon PM, Carrion-Petersen ML, et al. Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials. 2005; 26(5):557–68.
23. Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996; 34(3):220–33.
24. Boucher B, Cotterchio M, Kreiger N, Nadalin V, Block T, Block G. Validity and reliability of the Block98 food-frequency questionnaire in a sample of Canadian women. Public Health Nutr. 2006; 9(1):84–93.
25. Johnson BA, Herring AH, Ibrahim JG, Siega-Riz AM. Structured measurement error in nutritional epidemiology: applications in the Pregnancy, Infection, and Nutrition (PIN) Study. J Am Stat Assoc. 2007; 102(479):856–66.
26. Haines PS, Siega-Riz AM, Popkin BM. The Diet Quality Index revised: a measurement instrument for populations. J Am Diet Assoc. 1999; 99(6):697–704.
27. Washburn RA, Smith KW, Jette AM, Janney CA. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993; 46(2):153–62.
28. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P. Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol. 1994; 10(4):405–11.
29. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987; 48(8):314–8.
30. Cauley JA, Blackwell T, Zmuda JM, et al. Correlates of trabecular and cortical volumetric bone mineral density at the femoral neck and lumbar spine: the osteoporotic fractures in men study (MrOS). J Bone Miner Res. 2010; 25(9):1958–71.
31. Looker AC, Melton LJ 3rd, Borrud LG, Shepherd JA. Changes in femur neck bone density in US adults between 1988-1994 and 2005-2008: demographic patterns and possible determinants. Osteoporos Int. 2012; 23(2):771–80.
32. Sanders KM, Pasco JA, Ugoni AM, et al. The exclusion of high trauma fractures may underestimate the prevalence of bone fragility fractures in the community: the Geelong Osteoporosis Study. J Bone Miner Res. 1998; 13(8):1337–42.
33. Shtatland ES, Kleinman K, Cain EM. Model building in PROC PHREG with automatic variable selection and information criteria. Proceedings of the 30th Annual SAS Users Group International Conference. 2005 Apr 10–13. Paper 206-30. p. 1–10. http://www2.sas.com/proceedings/sugi30/toc.html.
34. Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999; 94:496–509.
35. Nguyen ND, Frost SA, Center JR, Eisman JA, Nguyen TV. Development of a nomogram for individualizing hip fracture risk in men and women. Osteoporos Int. 2007; 18(8):1109–17.
36. WHO Fracture RiskWorld Health Organization. FRAX® Assessment Tool. http://wwwshefacuk/FRAX/tooljsp.
37. Wu Q, Liu J, Gallegos-Orozco JF, Hentz JG. Depression, fracture risk, and bone loss: a meta-analysis of cohort studies. Osteoporos Int. 2010; 21(10):1627–35.
38. Wu Q, Qu W, Crowell MD, Hentz JG, Frey KA. Tricyclic antidepressant use and risk of fractures: a meta-analysis of cohort and case-control studies. J Bone Miner Res. 2013; 28(4):753–63.
39. Lewis CE, Ewing SK, Taylor BC, et al. Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007; 22(2):211–9.
40. Cauley JA, Fullman RL, Stone KL, et al. Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int. 2005; 16(12):1525–37.
41. Rabenda V, Nicolet D, Beaudart C, Bruyere O, Reginster JY. Relationship between use of antidepressants and risk of fractures: a meta-analysis. Osteoporos Int. 2013; 24(1):121–37.
42. American Geriatrics Society Beers Criteria Update Expert P. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012; 60(4):616–31.
43. de Rijk MC, Launer LJ, Berger K, et al. Prevalence of Parkinson's disease in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S21–3.
44. Tan L, Wang Y, Zhou L, et al. Parkinson's disease and risk of fracture: a meta-analysis of prospective cohort studies. PLoS One. 2014; 9(4):e94379.
45. Benzinger P, Rapp K, Maetzler W, et al. Risk for femoral fractures in Parkinson's disease patients with and without severe functional impairment. PLoS One. 2014; 9(5):e97073.
46. Harris-Hayes M, Willis AW, Klein SE, Czuppon S, Crowner B, Racette BA. Relative mortality in U.S. Medicare beneficiaries with Parkinson disease and hip and pelvic fractures. J Bone Joint Surg Am. 2014; 96(4):e27.
47. Huang YF, Cherng YG, Hsu SP, et al. Risk and adverse outcomes of fractures in patients with Parkinson's disease: two nationwide studies. Osteoporos Int. 2015; 26(6):1723–32.
48. Waring AC, Harrison S, Fink HA, et al. A prospective study of thyroid function, bone loss, and fractures in older men: the MrOS study. J Bone Miner Res. 2013; 28(3):472–9.
49. Leslie WD, Pahlavan PS, Tsang JF, Lix LM, Manitoba Bone Density Program. Prediction of hip and other osteoporotic fractures from hip geometry in a large clinical cohort. Osteoporos Int. 2009; 20(10):1767–74.
50. Klotzbuecher CM, Ross PD, Landsman PB, Abbott TA 3rd, Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res. 2000; 15(4):721–39.
51. Thompson B, Towler DA. Arterial calcification and bone physiology: role of the bone-vascular axis. Nat Rev Endocrinol. 2012; 8(9):529–43.
52. Sennerby U, Melhus H, Gedeborg R, et al. Cardiovascular diseases and risk of hip fracture. JAMA. 2009; 302(15):1666–73.
53. Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr. 2009; 90(6):1674–92.
54. Sennerby U, Farahmand B, Ahlbom A, Ljunghall S, Michaelsson K. Cardiovascular diseases and future risk of hip fracture in women. Osteoporos Int. 2007; 18(10):1355–62.
55. Beasley JM, LaCroix AZ, Larson JC, et al. Biomarker-calibrated protein intake and bone health in the Women's Health Initiative clinical trials and observational study. Am J Clin Nutr. 2014; 99(4):934–40.
56. Short KR, Vittone JL, Bigelow ML, Proctor DN, Nair KS. Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am J Physiol Endocrinol Metab. 2004; 286(1):E92–101.
57. US Department of Agriculture and US Department of Health and Human Services. Dietary Guidelines for Americans, 2010. 7th ed. Washington, DC: US Government Printing Office; December 2010. http://health.gov/dietaryguidelines/dga2010/dietaryguidelines2010.pdf.
58. Berry SD, Ngo L, Samelson EJ, Kiel DP. Competing risk of death: an important consideration in studies of older adults. J Am Geriatr Soc. 2010; 58(4):783–7.
59. Macleod AD, Taylor KS, Counsell CE. Mortality in Parkinson's disease: a systematic review and meta-analysis. Mov Disord. 2014; 29(13):1615–22.
60. Laulund AS, Nybo M, Brix TH, Abrahamsen B, Jorgensen HL, Hegedus L. Duration of thyroid dysfunction correlates with all-cause mortality. The OPENTHYRO Register Cohort. PLoS One. 2014; 9(10):e110437.
61. Critchley R, Khan SK, Yarnall AJ, Parker MJ, Deehan DJ. Occurrence, management and outcomes of hip fractures in patients with Parkinson's disease. Br Med Bull. 2015; 115:135–42.
62. Kanis JA, Johansson H, Oden A, et al. A family history of fracture and fracture risk: a meta-analysis. Bone. 2004; 35(5):1029–37.
63. Cauley JA, Harrison SL, Cawthon PM, et al. Objective measures of physical activity, fractures and falls: the Osteoporotic Fractures in Men study. J Am Geriatr Soc. 2013; 61(7):1080–8.
64. Sandhu SK, Nguyen ND, Center JR, Pocock NA, Eisman JA, Nguyen TV. Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int. 2010; 21(5):863–71.
65. Leslie WD, Lix LM, Johansson H, et al. Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res. 2010; 25(11):2350–8.
66. Collins GS, Mallett S, Altman DG. Predicting risk of osteoporotic and hip fracture in the United Kingdom: prospective independent and external validation of QFractureScores. BMJ. 2011; 342:d3651.
67. Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB. Incidence and mortality of hip fractures in the United States. JAMA. 2009; 302(14):1573–9.