Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

Oncotarget

Volumn 7, Issue 11, 2016, Pages 12975-12996

  Booth, Laurence ^a   Shuch, Brian ^b,c   Albers, Thomas ^g   Roberts, Jane L ^a   Tavallai, Mehrad ^a   Proniuk, Stefan ^e   Zukiwski, Alexander ^e   Wang, Dasheng ^d   Chen, Ching Shih ^d   Bottaro, Don ^c   Ecroyd, Heath ^f   Lebedyeva, Iryna O ^g   Dent, Paul ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e Arno Therapeutics   (United States)

^f UNIVERSITY OF WOLLONGONG   (Australia)

^g AUGUSTA UNIVERSITY   (United States)

Author keywords

ATPase; Chaperones; OSU 03012; Pazopanib; Sorafenib

Indexed keywords

2 AMINO N [4 [5 (2 PHENANTHRENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]PHENYL]ACETAMIDE; ACTIVATING TRANSCRIPTION FACTOR 4; ADENOSINE TRIPHOSPHATASE; BAG2 PROTEIN; BECLIN 1; CHAPERONE; FLICE INHIBITORY PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GRP75 PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 75; HEAT SHOCK PROTEIN 90; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PAZOPANIB; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN MCL 1; SILDENAFIL; THIOREDOXIN; ULK 1 PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SORAFENIB; SULFONAMIDE;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL VIABILITY; CELLULAR DISTRIBUTION; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION; TUMOR CELL; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR DOCKING SIMULATION; NIACINAMIDE; PHENYLUREA COMPOUNDS; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; SULFONAMIDES;

EID: 84962840558     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7349     Document Type: Article

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