Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes

ChemMedChem

Volumn 11, Issue 9, 2016, Pages 953-957

  Gui, Lin ^a,c   Zhang, Xiaoyi ^a,c   Li, Kelin ^b   Frankowski, Kevin J ^b   Li, Shan ^a,c   Wong, Daniel E ^a   Moen, Derek R ^a   Porubsky, Patrick R ^b   Lin, Henry J ^a   Schoenen, Frank J ^b   Chou, Tsui Fen ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

ATPase; cancer; p97; structure activity relationships; ubiquitin proteasome system

Indexed keywords

2 (2 AMINO 1H BENZO[D]IMIDAZOL 1 YL) N BENZYL 8 METHOXYQUINAZOLIN 4 AMINE; 2 (2H BENZO(B)[1,4]OXAZIN 4(3H) YL) N BENZYL 5,6,7,8 TETRAHYDROQUINAZOLIN 4 AMINE; ADENOSINE TRIPHOSPHATASE; PROTEIN INHIBITOR; PROTEIN P37; PROTEIN P97; UNCLASSIFIED DRUG; CDC48 PROTEIN; CELL CYCLE PROTEIN; ENZYME INHIBITOR; NPLOC4 PROTEIN, HUMAN; NUCLEAR PROTEIN; P37 PROTEIN, HUMAN; PROTEIN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UFD1L PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; IC50; METABOLISM; MUTATION; PRECLINICAL STUDY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; BINDING SITES; CELL CYCLE PROTEINS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEINS;

EID: 84962798388     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201600036     Document Type: Article

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