The influence of perioperative dexmedetomidine on patients undergoing cardiac surgery: A meta-analysis

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Geng, Jun ^a   Qian, Ju ^a   Cheng, Hao ^a,b   Ji, Fuhai ^a   Liu, Hong ^b  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE;

ANESTHESIA INDUCTION; ARTICLE; ATRIAL FIBRILLATION; BRADYCARDIA; DATA ANALYSIS; HEART SURGERY; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOTENSION; LENGTH OF STAY; META ANALYSIS; OUTCOME ASSESSMENT; POSTOPERATIVE DELIRIUM; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; QUALITY CONTROL; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SENSITIVITY ANALYSIS; TREATMENT RESPONSE; PERIOPERATIVE PERIOD; THORAX SURGERY;

DEXMEDETOMIDINE; HUMANS; PERIOPERATIVE CARE; THORACIC SURGICAL PROCEDURES;

EID: 84962791878     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0152829     Document Type: Article

References (52)

1. Mangano DT. Assessment of the patient with cardiac disease: an anesthesiologist's paradigm. Anesthesiology. 1999;91:1521-1526. doi: 10.1097/00000542-199911000-00046 PMID: 10551605
2. Coriat P, Beaussier M. Fast-tracking after coronary artery bypass graft surgery. Anesth Analg. 2001;92:1081-1083. doi: 10.1097/00000539-200105000-00001 PMID: 11323325
3. Hoy SM, Keating GM. Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation. Drugs. 2011;71:1481-1501. doi: 10. 2165/11207190-000000000-00000 PMID: 21812509
4. Lin YY, He B, Chen J, Wang ZN. Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? a meta-analysis. Crit Care. 2012;16:R169. doi: 10.1186/cc11646 PMID: 23016926
5. Asmussen S, Maybauer DM, Fraser JF, Jennings K, George S, Maybauer MO. A meta-analysis of analgesic and sedative effects of dexmedetomidine in burn patients. Burns. 2013;39:625-631. doi: 10. 1016/j.burns.2013.01.008 PMID: 23465796
6. Patel VJ, Ahmed SS, Nitu ME, Rigby MR. Vasovagal syncope and severe bradycardia following intranasal dexmedetomidine for pediatric procedural sedation. Paediatr Anaesth. 2014;24:446-448. doi: 10.1111/pan. 12368 PMID: 24571687
7. Tachibana K, Hashimoto T, Kato R, Uchida Y, Ito R, Takita K, et al. Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood. Paediatr Anaesth. 2012;22:713-719. doi: 10.1111/j.1460-9592.2012.03810.x PMID: 22309594
8. Jalonen J, Hynynen M, Kuitunen A, Heikkilä H, Perttilä J, Salmenperä M, et al. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology. 1997;86:331-345. PMID: 9054252
9. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, et al. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. Anesthesiology. 1995;82:620-633. doi: 10.1097/00000542-199503000-00003 PMID: 7879930
10. Wijeysundera DN, Naik JS, Scott Beattie W. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications. Am J Med. 2003;114:742-752. doi: 10.1016/s0002-9343 (03) 00165-7 PMID: 12829201
11. Biccard BM, Goga S, de Beurs J. Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials. Anaesthesia. 2008;63:4-14. doi: 10.1111/j.1365-2044. 2007.05306.x PMID: 18086064
12. Ji F, Li Z, Nguyen H, Young N, Shi P, Fleming N, et al. Perioperative dexmedetomidine improves outcomes of cardiac surgery. Circulation. 2013;127:1576-1584. doi: 10.1161/CIRCULATIONAHA.112. 000936 PMID: 23513068
13. Leino K, Hynynen M, Jalonen J, Salmenpera M, Scheinin H, Aantaa R, et al. Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study. BMC Anesthesiol. 2011;11:9. doi: 10.1186/1471-2253-11-9 PMID: 21605394
14. Cui J, Zhao H, Wang C, Sun JJ, Lu K, Ma D. Dexmedetomidine attenuates oxidative stress induced lung alveolar epithelial cell apoptosis in vitro. Oxid Med Cell Longev. 2015;2015:358396. doi: 10. 1155/2015/358396 PMID: 25838866
15. Wang ZX, Huang CY, Hua YP, Huang WQ, Deng LH, Liu KX. Dexmedetomidine reduces intestinal and hepatic injury after hepatectomy with inflow occlusion under general anaesthesia: a randomized controlled trial. Br J Anaesth. 2014;112:1055-1064. doi: 10.1093/bja/aeu132 PMID: 24771805
16. Szumita PM, Baroletti SA, Anger KE, Wechsler ME. Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine. Am J Health Syst Pharm. 2007;64:37-44. doi: 10.2146/ajhp050508 PMID: 17189578
17. Kamibayashi T, Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology. 2000;93:1345-1349. PMID: 11046225
18. Corbett SM, Rebuck JA, Greene CM, Callas PW, Neale BW, Healey MA, et al. Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Crit Care Med. 2005;33:940-945. doi: 10.1097/01.ccm.0000162565.18193.e5 PMID: 15891317
19. Dasta JF, Kane-Gill SL, Durtschi AJ. Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data. Ann Pharmacother. 2004;38:1130-1135. doi: 10.1345/aph.1D615 PMID: 15173557
20. Ingersoll-Weng E, Manecke GR Jr, Thistlethwaite PA. Dexmedetomidine and cardiac arrest. Anesthesiology. 2004;100:738-739. doi: 10.1097/00000542-200403000-00040 PMID: 15108994
21. Sichrovsky TC, Mittal S, Steinberg JS. Dexmedetomidine sedation leading to refractory cardiogenic shock. Anesth Analg. 2008;106:1784-1786. doi: 10.1213/ane.0b013e318172fafc PMID: 18499610
22. Ickeringill M, Shehabi Y, Adamson H, Ruettimann U. Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: hemodynamic effects and efficacy. Anaesth Intensive Care. 2004;32:741-745. PMID: 15648981
23. Shehabi Y, Grant P, Wolfenden H, Hammond N, Bass F, Campbell M, et al. Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial. Anesthesiology. 2009;111:1075-1084. doi: 10.1097/ALN.0b013e3181b6a783 PMID: 19786862
24. Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, Reitz BA. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009;50:206-217. doi: 10. 1176/appi.psy.50.3.206 PMID: 19567759
25. Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009;301:489-499. doi: 10. 1001/jama.2009.56 PMID: 19188334
26. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298:2644-2653. doi: 10.1001/jama.298.22.2644 PMID: 18073360
27. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi: 10.1136/bmj. d5928 PMID: 22008217
28. Sun L, Guo R, Sun L. Dexmedetomidine for preventing sevoflurane-related emergence agitation in children: a meta-analysis of randomized controlled trials. Acta Anaesthesiol Scand. 2014;58:642-650. doi: 10.1111/aas.12292 PMID: 24588393
29. Higgins JPT, Altman DG. Cochrane handbook for systematic reviews of interventions. Oxford: Wiley. 2008.
30. Balkanay OO, Goksedef D, Omeroglu SN, Ipek G. The dose-related effects of dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting: a randomized, triple-blind, placebo-controlled study. Interact Cardiovasc Thorac Surg. 2015;20:209-214. doi: 10.1093/icvts/ivu367 PMID: 25392341
31. Herr DL, Sum-Ping ST, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidinebased versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth. 2003;17:576-584. doi: 10.1016/s1053-0770 (03) 00200-3 PMID: 14579210
32. Ren J, Zhang H, Huang L, Liu Y, Liu F, Dong Z. Protective effect of dexmedetomidine in coronary artery bypass grafting surgery. Exp Ther Med. 2013;6:497-502. doi: 10.3892/etm.2013.1183 PMID: 24137215
33. Karaman Y, Abud B, Tekgul ZT, Cakmak M, Yildiz M, Gonullu M. Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fast-track recovery room setting. J Anesth. 2015;29:522-528. doi: 10.1007/s00540-015-1975-2 PMID: 25617159
34. Park JB, Bang SH, Chee HK, Kim JS, Lee SA, Shin JK. Efficacy and safety of dexmedetomidine for postoperative delirium in adult cardiac surgery on cardiopulmonary bypass. Korean J Thorac Cardiovasc Surg. 2014;47:249-254. doi: 10.5090/kjtcs.2014.47.3.249 PMID: 25207222
35. Tosun Z, Baktir M, Kahraman HC, Baskol G, Guler G, Boyaci A. Does dexmedetomidine provide cardioprotection in coronary artery bypass grafting with cardiopulmonary bypass? A pilot study. J Cardiothorac Vasc Anesth. 2013;27:710-715. doi: 10.1053/j.jvca.2012.12.013 PMID: 23725681
36. Abd Aziz N, Chue MC, Yong CY, Hassan Y, Awaisu A, Hassan J, et al. Efficacy and safety of dexmedetomidine versus morphine in post-operative cardiac surgery patients. Int J Clin Pharm. 2011;33:150-154. doi: 10.1007/s11096-011-9480-7 PMID: 21744187
37. Khalil MA, Abdel Azeem MS. The impact of dexmedetomidine infusion in sparing morphine consumption in off-pump coronary artery bypass grafting. Semin Cardiothorac Vasc Anesth. 2013;17:66-71. doi: 10.1177/1089253212463969 PMID: 23108415
38. Polderman KH, Smit E. Dealing with the delirium dilemma. Crit Care. 2005;9:335-336. doi: 10.1186/cc3755 PMID: 16137377
39. Inouye SK. Delirium in older persons. N Engl J Med. 2006;354:1157-1166. doi: 10.1056/NEJMra052321 PMID: 16540616
40. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291:1753-1762. doi: 10.1001/jama.291.14.1753 PMID: 15082703
41. Milbrandt EB, Deppen S, Harrison PL, Shintani AK, Speroff T, Stiles RA, et al. Costs associated with delirium in mechanically ventilated patients. Critical Care Medicine. 2004;32:955-962. doi: 10.1097/01.ccm.0000119429.16055.92 PMID: 15071384
42. Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg. 2000;90:699-705. doi: 10.1097/00000539-200003000-00035 PMID: 10702460
43. Martin E, Ramsay G, Mantz J, Sum-Ping ST. The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med. 2003;18:29-41. doi: 10.1177/0885066602239122 PMID: 15189665
44. Maze M, Scarfini C, Cavaliere F. New agents for sedation in the intensive care unit. Crit Care Clin. 2001;17:881-897. doi: 10.1016/S0749-0704 (05) 70185-8 PMID: 11762266
45. Videira RL, Ferreira RM. Dexmedetomidine and asystole. Anesthesiology. 2004;101:1479-1480. doi: 10.1097/00000542-200412000-00037 PMID: 15564965
46. Mariscalco G, Klersy C, Zanobini M, Banach M, Ferrarese S, Borsani P, et al. Atrial fibrillation after isolated coronary surgery affects late survival. Circulation. 2008;118:1612-1618. doi: 10.1161/CIRCULATIONAHA.108.777789 PMID: 18824644
47. Amar D, Burt ME, Bains MS, Leung DH. Symptomatic tachydys-rhythmias after esophagectomy: incidence and outcome measures. Ann Thorac Surg. 1996;61:1506-1509. doi: 10.1016/0003-4975 (96) 00111-7 PMID: 8633967
48. Amar D, Roistacher N, Burt M, Reinsel RA, Ginsberg RJ, Wilson RS. Clinical and echocardiographic correlates of symptomatic tachydysrhythmias after noncardiac thoracic surgery. Chest. 1995;108:349-354. doi: 10.1378/chest.108.2.349 PMID: 7634865
49. Harpole DH, Liptay MJ, De Camp MM Jr, Mentzer SJ, Swanson SJ, Sugarbaker DJ. Prospective analysis of pneumonectomy: risk factors for major morbidity and cardiac dysrhythmias. Ann Thorac Surg. 1996;61:977-982. doi: 10.1016/0003-4975 (95) 01174-9 PMID: 8619729
50. Polanczyk CA, Goldman L, Marcantonio ER, Orav EJ, Lee TH. Supraventricular arrhythmia in patients having noncardiac surgery: clinical correlates and effect on length of stay. Ann Intern Med. 1998;129:279-285. doi: 10.7326/0003-4819-129-4-199808150-00003 PMID: 9729180
51. Taylor GJ, Malik SA, Colliver JA, Dove JT, Moses HW, Mikell FL, et al. Usefulness of atrial fibrillation as a predictor of stroke after isolated coronary artery bypass grafting. Am J Cardiol. 1987;60:905-907. doi: 10.1016/0002-9149 (87) 91045-9 PMID: 3661408
52. Ai D, Xu G, Feng L, Yu J, Banchs J, Vaporciyan AA, et al. Dexmedetomidine does not reduce atrial fibrillation after lung cancer surgery. J Cardiothorac Vasc Anesth. 2015;29:396-401. doi: 10.1053/j. jvca.2014.05.013 PMID: 25440618