Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data

Annals of Pharmacotherapy

Volumn 38, Issue 7-8, 2004, Pages 1130-1135

  Dasta, Joseph F ^a   Kane Gill, Sandra L ^b   Durtschi, Amy J ^a,c,d  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c ABBOTT LABORATORIES   (United States)

^d Dex Registry Study Group

Author keywords

Adverse reactions; Dexmedetomidine; Drug safety

Indexed keywords

DEXMEDETOMIDINE;

ADVERSE DRUG REACTION; ARTIFICIAL VENTILATION; BRADYCARDIA; CLINICAL PRACTICE; DEMOGRAPHY; DOSE RESPONSE; DRUG INFUSION; DRUG LABELING; DRUG SAFETY; DRUG UTILIZATION; EXTUBATION; HEART ATRIUM FIBRILLATION; HUMAN; HYPERTENSION; HYPOTENSION; HYPOXIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MAXIMUM PERMISSIBLE DOSE; PRESCRIPTION; PRIORITY JOURNAL; PUBLICATION; REVIEW; SEDATION;

DEXMEDETOMIDINE; HUMANS; HYPNOTICS AND SEDATIVES; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES; PRESCRIPTIONS, DRUG; RETROSPECTIVE STUDIES;

EID: 3042645548     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1D615     Document Type: Review

References (18)

1. Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs 2000;59:263-8.
2. Coursin DB, Maccioli GA. Dexmedetomidine. Curr Opin Crit Care 2001;7:221-6.
3. Lasser KE, Allen PD, Woolhandler SJ, Himmelstein DU, Wolfe SM, Bor DH. Timing of new black box warnings and withdrawals for prescription medications. JAMA 2002;287:2215-20.
4. World Health Organization. International drug monitoring: the role of the hospital. Technical report series no. 425. Geneva: World Health Organization, 1966.
5. Hartwig SC, Denger SD, Schneider PJ. Severity-indexed, incident report-based medication error-reporting program. Am J Hosp Pharm 1991;48:2611-6.
6. Herr DL, Sum-Ping STJ, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth 2003;17:576-84.
7. Venn RM, Bradswaw CJ, Spencer R, Brealey D, Caudwell E, Nauhton C, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999;54:1136-42.
8. Triltsch AE, Welte M, von Homeyer P, Grobe J, Genahr A, Moshirzadeh M, et al. Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled Phase II study. Crit Care Med 2002;30:1007-14.
9. Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 2000;4:302-8.
10. Angela A, Cassell C, Gargia-Rodriquez CR, El-Moalem HE, Sum-Ping ST. Effects of dexmedetomidine on respiration (abstract). Anesthesiology 2000;93:A483.
11. Venn RM, Newman PJ, Grounds RM. A Phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intens Care Med 2003;29:201-7.
12. Riker RR, Ramsay MA, Prielipp RC, Jorden V. Dexmedetomidine provides effective long-term sedation for intubated ICU patients when compared with midazolam: a randomized open-label pilot study (abstract). Chest 2001;120:272.
13. Multz AS. Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal. Anesth Analg 2003;96:1054-5.
14. Jorden VS. Characterization and management of dexmedetomidine-related hypotension following CABG (abstract). Crit Care Med 2002;30:A157.
15. Product labeling. Precedex (dexmedetomidine). Abbott Park, IL: Abbott Laboratories, February 2001.
16. Jorden VSB, Tung A. Dexmedetomidine: clinical update. Semin Anesth Periop Med Pain 2002;21:265-74.
17. Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth 2001;87:684-90.
18. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30:119-41.