메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis

Author keywords

[No Author keywords available]

Indexed keywords

FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; G141 COMPOUND; PROTEIN KINASE INHIBITOR; SPIRO COMPOUND;

EID: 84962685860     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24042     Document Type: Article
Times cited : (36)

References (39)
  • 1
    • 79959341732 scopus 로고    scopus 로고
    • Osteoarthritis: An update with relevance for clinical practice
    • Bijlsma, J. W., Berenbaum, F. & Lafeber, F. P. Osteoarthritis: an update with relevance for clinical practice. Lancet 377, 2115-2126, doi: 10. 1016/S0140-6736(11)60243-2 (2011).
    • (2011) Lancet , vol.377 , pp. 2115-2126
    • Bijlsma, J.W.1    Berenbaum, F.2    Lafeber, F.P.3
  • 2
    • 84864459232 scopus 로고    scopus 로고
    • A Wnt/beta-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes
    • Ma, B., van Blitterswijk, C. A. & Karperien, M. A Wnt/beta-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes. Arthritis Rheum 64, 2589-2600, doi: 10. 1002/art. 34425 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 2589-2600
    • Ma, B.1    Van Blitterswijk, C.A.2    Karperien, M.3
  • 3
    • 84935036182 scopus 로고    scopus 로고
    • Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
    • Zhang, Y. et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann Rheum Dis 74, 1432-1440, doi: 10. 1136/annrheumdis-2013-204599 (2015).
    • (2015) Ann Rheum Dis , vol.74 , pp. 1432-1440
    • Zhang, Y.1
  • 4
    • 71549136203 scopus 로고    scopus 로고
    • Modulating hedgehog signaling can attenuate the severity of osteoarthritis
    • Lin, A. C. et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med 15, 1421-1425, doi: 10. 1038/ nm. 2055 (2009).
    • (2009) Nat Med , vol.15 , pp. 1421-1425
    • Lin, A.C.1
  • 5
    • 84874231192 scopus 로고    scopus 로고
    • Fibroblast growth factor control of cartilage homeostasis
    • Ellman, M. B. et al. Fibroblast growth factor control of cartilage homeostasis. J Cell Biochem 114, 735-742, doi: 10. 1002/jcb. 24418 (2013).
    • (2013) J Cell Biochem , vol.114 , pp. 735-742
    • Ellman, M.B.1
  • 6
    • 84870346835 scopus 로고    scopus 로고
    • Explaining the Fibroblast Growth Factor Paradox in Osteoarthritis: Lessons from Conditional Knockout Mice
    • Vincent, T. L. Explaining the Fibroblast Growth Factor Paradox in Osteoarthritis: Lessons From Conditional Knockout Mice. Arthritis Rheum 64, 3835-3838, doi: 10. 1002/Art. 34648 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 3835-3838
    • Vincent, T.L.1
  • 7
    • 33744763965 scopus 로고    scopus 로고
    • Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice
    • Valverde-Franco, G. et al. Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice. Hum Mol Genet 15, 1783-1792, doi: 10. 1093/Hmg/Ddl100 (2006).
    • (2006) Hum Mol Genet , vol.15 , pp. 1783-1792
    • Valverde-Franco, G.1
  • 8
    • 84870308824 scopus 로고    scopus 로고
    • Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice
    • Weng, T. et al. Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis Rheum 64, 3982-3992, doi: 10. 1002/art. 34645 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 3982-3992
    • Weng, T.1
  • 9
    • 80051485778 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes
    • Yan, D. et al. Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Res Ther 13, doi: 10. 1186/Ar3441 (2011).
    • (2011) Arthritis Res Ther , vol.13
    • Yan, D.1
  • 10
    • 84928323469 scopus 로고    scopus 로고
    • Discovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancer
    • Wu, J. et al. Discovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancer. BMC cancer 15, 276, doi: 10. 1186/s12885-015-1307-9 (2015).
    • (2015) BMC Cancer , vol.15 , pp. 276
    • Wu, J.1
  • 11
    • 84893710835 scopus 로고    scopus 로고
    • Discovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential on non-smallcell lung cancer
    • Wang, Y. et al. Discovery and identification of new non-ATP competitive FGFR1 inhibitors with therapeutic potential on non-smallcell lung cancer. Cancer Lett 344, 82-89, doi: 10. 1016/j. canlet. 2013. 10. 016 (2014).
    • (2014) Cancer Lett , vol.344 , pp. 82-89
    • Wang, Y.1
  • 12
    • 84863689150 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCdelta pathway in human articular chondrocytes
    • Yan, D., Chen, D. & Im, H. J. Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCdelta pathway in human articular chondrocytes. J Cell Biochem 113, 2856-2865, doi: 10. 1002/jcb. 24160 (2012).
    • (2012) J Cell Biochem , vol.113 , pp. 2856-2865
    • Yan, D.1    Chen, D.2    Im, H.J.3
  • 13
    • 1042278739 scopus 로고    scopus 로고
    • Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3
    • Sharif, M., Whitehouse, A., Sharman, P., Perry, M. & Adams, M. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum 50, 507-515, doi: 10. 1002/art. 20020 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 507-515
    • Sharif, M.1    Whitehouse, A.2    Sharman, P.3    Perry, M.4    Adams, M.5
  • 14
    • 84905577960 scopus 로고    scopus 로고
    • Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis
    • Weng, T. et al. Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis. Osteoarthritis Cartilage 22, 1197-1205, doi: 10. 1016/j. joca. 2014. 06. 031 (2014).
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. 1197-1205
    • Weng, T.1
  • 15
    • 20144378016 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis
    • Davidson, D. et al. Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem 280, 20509-20515, doi: 10. 1074/jbc. M410148200 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 20509-20515
    • Davidson, D.1
  • 16
    • 20944443514 scopus 로고    scopus 로고
    • Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis
    • Moore, E. E. et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage 13, 623-631, doi: 10. 1016/j. joca. 2005. 03. 003 (2005).
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 623-631
    • Moore, E.E.1
  • 17
    • 50849101663 scopus 로고    scopus 로고
    • Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
    • Uchii, M. et al. Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. Arthritis Res Ther 10, R90, doi: 10. 1186/ ar2474 (2008).
    • (2008) Arthritis Res Ther , vol.10 , pp. R90
    • Uchii, M.1
  • 18
    • 84962635374 scopus 로고    scopus 로고
    • The Chondroprotective Effect of Fgf9 in an Experiment Model of Osteoarthritis
    • Wang, S. X., Bendele, A. M. & Moore, E. M. The Chondroprotective Effect of Fgf9 in an Experiment Model of Osteoarthritis. Osteoarthritis Cartilage 20, S40-S41 (2012).
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. S40-S41
    • Wang, S.X.1    Bendele, A.M.2    Moore, E.M.3
  • 19
    • 29144507688 scopus 로고    scopus 로고
    • Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes
    • Loeser, R. F., Chubinskaya, S., Pacione, C. & Im, H. J. Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes. Arthritis Rheum 52, 3910-3917, doi: 10. 1002/ art. 21472 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 3910-3917
    • Loeser, R.F.1    Chubinskaya, S.2    Pacione, C.3    Im, H.J.4
  • 20
    • 80051485778 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes
    • Yan, D. et al. Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. Arthritis Res Ther 13, doi: 10. 1186/ar3441 (2011).
    • (2011) Arthritis Res Ther , vol.13
    • Yan, D.1
  • 21
    • 67650034636 scopus 로고    scopus 로고
    • Fibroblast Growth Factor 2 Is an Intrinsic Chondroprotective Agent That Suppresses ADAMTS-5 and Delays Cartilage Degradation in Murine Osteoarthritis
    • Chia, S. L. et al. Fibroblast Growth Factor 2 Is an Intrinsic Chondroprotective Agent That Suppresses ADAMTS-5 and Delays Cartilage Degradation in Murine Osteoarthritis. Arthritis Rheum 60, 2019-2027, doi: 10. 1002/Art. 24654 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 2019-2027
    • Chia, S.L.1
  • 22
    • 46149113433 scopus 로고    scopus 로고
    • Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis
    • Ellman, M. B., An, H. S., Muddasani, P. & Im, H. J. Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene 420, 82-89, doi: 10. 1016/j. gene. 2008. 04. 019 (2008).
    • (2008) Gene , vol.420 , pp. 82-89
    • Ellman, M.B.1    An, H.S.2    Muddasani, P.3    Im, H.J.4
  • 23
    • 35748961128 scopus 로고    scopus 로고
    • Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes
    • Muddasani, P., Norman, J. C., Ellman, M., van Wijnen, A. J. & Im, H.-J. Basic fibroblast growth factor activates the MAPK and NF kappa B pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem 282, 31409-31421, doi: 10. 1074/jbc. M706508200 (2007).
    • (2007) J Biol Chem , vol.282 , pp. 31409-31421
    • Muddasani, P.1    Norman, J.C.2    Ellman, M.3    Van Wijnen, A.J.4    Im, H.-J.5
  • 24
    • 0037975671 scopus 로고    scopus 로고
    • In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes
    • Pelletier, J. P. et al. In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthritis Rheum 48, 1582-1593, doi: 10. 1002/art. 11014 (2003).
    • (2003) Arthritis Rheum , vol.48 , pp. 1582-1593
    • Pelletier, J.P.1
  • 25
    • 33746674531 scopus 로고    scopus 로고
    • P38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes
    • Radons, J., Bosserhoff, A. K., Grassel, S., Falk, W. & Schubert, T. E. p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes. Int J Mol Med 17, 661-668 (2006).
    • (2006) Int J Mol Med , vol.17 , pp. 661-668
    • Radons, J.1    Bosserhoff, A.K.2    Grassel, S.3    Falk, W.4    Schubert, T.E.5
  • 26
    • 84857138403 scopus 로고    scopus 로고
    • Chondrocyte hypertrophy and osteoarthritis: Role in initiation and progression of cartilage degeneration?
    • van der Kraan, P. M. & van den Berg, W. B. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? Osteoarthritis Cartilage 20, 223-232, doi: 10. 1016/j. joca. 2011. 12. 003 (2012).
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 223-232
    • Van Der Kraan, P.M.1    Van Den Berg, W.B.2
  • 27
    • 84924287483 scopus 로고    scopus 로고
    • Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
    • Takayama, K. et al. Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis. Arthritis Res Ther 16, 482, doi: 10. 1186/s13075-014-0482-4 (2014).
    • (2014) Arthritis Res Ther , vol.16 , pp. 482
    • Takayama, K.1
  • 28
    • 84887439643 scopus 로고    scopus 로고
    • Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes
    • Lawson, K. A. et al. Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes. J Biol Chem 288, 32119-32125, doi: 10. 1074/jbc. M113. 473827 (2013).
    • (2013) J Biol Chem , vol.288 , pp. 32119-32125
    • Lawson, K.A.1
  • 29
    • 33745041925 scopus 로고    scopus 로고
    • Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis
    • DLima, D., Hermida, J., Hashimoto, S., Colwell, C. & Lotz, M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 54, 1814-1821, doi: 10. 1002/art. 21874 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 1814-1821
    • Dlima, D.1    Hermida, J.2    Hashimoto, S.3    Colwell, C.4    Lotz, M.5
  • 30
    • 0037097976 scopus 로고    scopus 로고
    • FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    • Ornitz, D. M. & Marie, P. J. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 16, 1446-1465 (2002).
    • (2002) Genes Dev , vol.16 , pp. 1446-1465
    • Ornitz, D.M.1    Marie, P.J.2
  • 31
    • 0032557555 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia
    • Legeai-Mallet, L., Benoist-Lasselin, C., Delezoide, A. L., Munnich, A. & Bonaventure, J. Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia. J Biol Chem 273, 13007-13014 (1998).
    • (1998) J Biol Chem , vol.273 , pp. 13007-13014
    • Legeai-Mallet, L.1    Benoist-Lasselin, C.2    Delezoide, A.L.3    Munnich, A.4    Bonaventure, J.5
  • 32
    • 0034960254 scopus 로고    scopus 로고
    • STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    • Sahni, M., Raz, R., Coffin, J. D., Levy, D. & Basilico, C. STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128, 2119-2129 (2001).
    • (2001) Development , vol.128 , pp. 2119-2129
    • Sahni, M.1    Raz, R.2    Coffin, J.D.3    Levy, D.4    Basilico, C.5
  • 33
    • 84962774652 scopus 로고    scopus 로고
    • Sprifermin (Rhfgf18) Has an Anabolic Effect on Human Osteoarthritic Chondrocytes Involving Fgfr3 and Erk1/2 but Not P38 Alpha and Jnks
    • Gigout, A., Lindemann, S. & Guehring, H. Sprifermin (Rhfgf18) Has an Anabolic Effect on Human Osteoarthritic Chondrocytes Involving Fgfr3 and Erk1/2 but Not P38 Alpha and Jnks. Osteoarthritis Cartilage 22, S164-S164 (2014).
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. S164-S164
    • Gigout, A.1    Lindemann, S.2    Guehring, H.3
  • 34
    • 38949090015 scopus 로고    scopus 로고
    • Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin
    • Liang, G. et al. Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin. Bioorg Med Chem Lett 18, 1525-1529 (2008).
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 1525-1529
    • Liang, G.1
  • 35
    • 84861016275 scopus 로고    scopus 로고
    • Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family
    • Li, X. et al. Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family. J Cell Biochem 113, 2532-2542, doi: 10. 1002/jcb. 24129 (2012).
    • (2012) J Cell Biochem , vol.113 , pp. 2532-2542
    • Li, X.1
  • 36
    • 79952405776 scopus 로고    scopus 로고
    • Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
    • Stanton, H. et al. Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nat Protoc 6, 388-404, doi: 10. 1038/ nprot. 2010. 179 (2011).
    • (2011) Nat Protoc , vol.6 , pp. 388-404
    • Stanton, H.1
  • 37
    • 84899712233 scopus 로고    scopus 로고
    • Lithium protects against cartilage degradation in osteoarthritis
    • Minashima, T., Zhang, Y., Lee, Y. & Kirsch, T. Lithium protects against cartilage degradation in osteoarthritis. Arthritis Rheum 66, 1228-1236, doi: 10. 1002/art. 38373 (2014).
    • (2014) Arthritis Rheum , vol.66 , pp. 1228-1236
    • Minashima, T.1    Zhang, Y.2    Lee, Y.3    Kirsch, T.4
  • 38
    • 34548566958 scopus 로고    scopus 로고
    • The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
    • Glasson, S. S., Blanchet, T. J. & Morris, E. A. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 15, 1061-1069, doi: 10. 1016/j. joca. 2007. 03. 006 (2007).
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 1061-1069
    • Glasson, S.S.1    Blanchet, T.J.2    Morris, E.A.3
  • 39
    • 77956924858 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - Recommendations for histological assessments of osteoarthritis in the mouse
    • Glasson, S. S., Chambers, M. G., Van Den Berg, W. B. & Little, C. B. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 18 Suppl 3, S17-23, doi: 10. 1016/j. joca. 2010. 05. 025 (2010).
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. S17-23
    • Glasson, S.S.1    Chambers, M.G.2    Van Den Berg, W.B.3    Little, C.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.