GPR40 receptor activation leads to CREB phosphorylation and improves cognitive performance in an Alzheimer's disease mouse model

Neurobiology of Learning and Memory

Volumn 131, Issue , 2016, Pages 46-55

  Khan, Muhammad Zahid ^a   Zhuang, Xuxu ^a   He, Ling ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Behavioral tests; CAMP response element binding protein; GPR40 receptor; Neurotropic factors; Spatial learning and memory

Indexed keywords

AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DONEPEZIL; G PROTEIN COUPLED RECEPTOR 40; GW 9508; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CREBBP PROTEIN, MOUSE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; GPR40 PROTEIN, MOUSE; GW9508; METHYLAMINE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PROPIONIC ACID DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; ATTENTION; BRAIN LEVEL; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; DRUG TARGETING; HIPPOCAMPAL NEURONAL CULTURE; HOLE BOARD DISCRIMINATION TEST; LATENT PERIOD; LEARNING AND MEMORY TEST; LOW DRUG DOSE; MALE; MOLECULAR DYNAMICS; MORRIS WATER MAZE TEST; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OUTCOME ASSESSMENT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REFERENCE MEMORY; SPATIAL LEARNING; SPATIAL MEMORY; STEP THROUGH PASSIVE TEST; WESTERN BLOTTING; WORKING MEMORY; AGONISTS; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED; COGNITIVE DEFECT; DISEASE MODEL; DRUG EFFECTS; HIPPOCAMPUS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BEHAVIOR, ANIMAL; COGNITIVE DYSFUNCTION; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; METHYLAMINES; MICE; MICE, INBRED ICR; NERVE GROWTH FACTORS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PROPIONATES; RECEPTORS, G-PROTEIN-COUPLED; SPATIAL LEARNING; SPATIAL MEMORY;

EID: 84962574533     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2016.03.006     Document Type: Article

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