Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition

Thyroid

Volumn 26, Issue 3, 2016, Pages 347-355

  Samuels, Mary H ^a   Kolobova, Irina ^a   Smeraglio, Anne ^b   Peters, Dawn ^c   Purnell, Jonathan Q ^a   Schuff, Kathryn G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; LIOTHYRONINE; THYROTROPIN; ANTITHYROID AGENT; BIOLOGICAL MARKER; THYROXINE;

ACCELEROMETER; ADULT; ARTICLE; BODY COMPOSITION; CALORIC INTAKE; CALORIMETRY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FREE LIOTHYRONINE INDEX; HORMONE SUBSTITUTION; HUMAN; LIOTHYRONINE BLOOD LEVEL; LIPID OXIDATION; MAJOR CLINICAL STUDY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RESTING ENERGY EXPENDITURE; THYROID FUNCTION TEST; THYROTROPIN BLOOD LEVEL; ADVERSE EFFECTS; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; DRUG EFFECTS; ENERGY METABOLISM; HYPOTHYROIDISM; INDIRECT CALORIMETRY; MIDDLE AGED; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; QUESTIONNAIRE; TREATMENT OUTCOME; YOUNG ADULT;

ABSORPTIOMETRY, PHOTON; ADULT; ANTITHYROID AGENTS; BIOMARKERS; BODY COMPOSITION; CALORIMETRY, INDIRECT; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; ENERGY INTAKE; ENERGY METABOLISM; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; MIDDLE AGED; OXIDATION-REDUCTION; SURVEYS AND QUESTIONNAIRES; THYROTROPIN; THYROXINE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84962566590     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2015.0345     Document Type: Article

References (49)

1. Biondi B, Cooper DS. (2010). Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer. Thyroid 20: 135-146
2. Mullur R, Liu YY, Brent GA. (2014). Thyroid hormone regulation of metabolism. Physiol Rev 94: 355-382
3. Johannsen DL, Galgani JE, Johannsen NM, Zhang Z, Covington JD, Ravussin E. (2012). Effect of short-Term thyroxine administration on energy metabolism and mitochondrial efficiency in humans. PLoS One 7: e40837
4. Barbe P, Larrouy D, Boulanger C, Chevillotte E, Viguerie N, Thalamas C, Oliva Trastoy M, Roques M, Vidal H, Langin D. (2001). Triiodothyronine-mediated up-regulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes. FASEB J 15: 13-15
5. Bracco D, Morin O, Liang H, Jéquier E, Burger AG, Schutz Y. (1996). Changes in sleeping and basal energy expenditure and substrate oxidation induced by short term thyroxin administration in man. Obes Res 4: 213-219
6. Lovejoy JC, Smith SR, Bray GA, DeLany JP, Rood JC, Gouvier D, Windhauser M, Ryan DH, Macchiavelli R, Tulley R 1997A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men. J Clin Endocrinol Metab 82: 765-770
7. Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI. (2001). Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest 108: 733-737
8. Heemstra KA, Smit JW, Eustatia-Rutten CF, Heijboer AC, Frölich M, Romijn JA, Corssmit EP. (2006). Glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of euthyroidism, a randomised controlled trial. Clin Endocrinol (Oxf) 65: 737-744
9. Vigário Pdos S, Chachamovitz DS, Cordeiro MF, Teixeira Pde F, de Castro CL, de Oliveira FP, Vaisman M. (2011). Effects of physical activity on body composition and fatigue perception in patients on thyrotropin-suppressive therapy for differentiated thyroid carcinoma. Thyroid 21: 695-700
10. Polotsky HN, Brokhin M, Omry G, Polotsky AJ, Tuttle RM. (2012). Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors. Clin Endocrinol (Oxf) 76: 582-585
11. Dubois S, Abraham P, Rohmer V, Rodien P, Audran M, Dumas JF, Ritz P. (2008). Thyroxine therapy in euthyroid patients does not affect body composition or muscular function. Thyroid 18: 13-19
12. Wolf M, Weigert A, Kreymann G. (1996). Body composition and energy expenditure in thyroidectomized patients during short-Term hypothyroidism and thyrotropin-suppressive thyroxine therapy. Eur J Endocrinol 134: 168-173
13. Compher C, Frankenfield D, Keim N, Roth-Yousey L. (2006). Evidence Analysis Working Group. Best practice methods to apply to measurement of resting metabolic rate in adults: a systematic review. J Am Diet Assoc 106: 881-903
14. Frayn KN. (1983). Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol Respir Environ Exercise Physiol 55: 628-634
15. Reed GW, Hill JO. (1996). Measuring the thermic effect of food. Am J Clin Nutr 63: 164-169
16. Feskanich D, Sielaff B, Chong K, Bartsch G. (1989). Computerized collection and analysis of dietary intake information. Comput Methods Programs Biomed 30: 47-57
17. Kvetny J. (2005). Subclinical hyperthyroidism in patients with nodular goiter represents a hypermetabolic state. Exp Clin Endocrinol Diabetes 113: 122-126
18. van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW. (2005). Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90: 6403-6409
19. Greenlund LJ, Nair KS, Brennan MD. (2008). Changes in body composition in women following treatment of overt and subclinical hyperthyroidism. Endocr Pract 14: 973-978
20. Jonklaas J, Davidson B, Bhagat S, Soldin SJ. (2008). Triiodothyronine levels in athyreotic individuals during levothyroxine therapy. JAMA 299: 769-777
21. Astrup A, Buemann B, Christensen NJ, Madsen J, Gluud C, Bennett P, Svenstrup B. (1992). The contribution of body composition, substrates, and hormones to the variability in energy expenditure and substrate utilization in premenopausal women. J Clin Endocrinol Metab 74: 279-286
22. Svendsen OL, Hassager C, Christiansen C. (1993). Impact of regional and total body composition and hormones on resting energy expenditure in overweight postmenopausal women. Metabolism 42: 1588-1591
23. Toubro S, Sørensen TI, Rønn B, Christensen NJ, Astrup A. (1996). Twenty-four-hour energy expenditure: the role of body composition, thyroid status, sympathetic activity, and family membership. J Clin Endocrinol Metab 81: 2670-2674
24. Kvetny J. (2003). The significance of clinical euthyroidism on reference range for thyroid hormones. Eur J Intern Med 14: 315-320
25. al-Adsani H, Hoffer LJ, Silva JE. (1997). Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J Clin Endocrinol Metab 82: 1118-1125
26. Boeving A, Paz-Filho G, Radominski RB, Graf H, Amaral de Carvalho G. (2011). Low-normal or high-normal thyrotropin target levels during treatment of hypothyroidism: a prospective, comparative study. Thyroid 21: 355-360
27. Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM. (2014). Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association task force on thyroid hormone replacement. Thyroid 24: 1670-1751
28. Ito M, Miyauchi A, Morita S, Kudo T, Nishihara E, Kihara M, Takamura Y, Ito Y, Kobayashi K, Miya A, Kubota S, Amino N. (2012). TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy. Eur J Endocrinol 167: 373-378
29. Hoang TD, Olsen CH, Mai VQ, Clyde PW, Shakir MK. (2013). Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab 98: 1982-1990
30. Celi FS, Zemskova M, Linderman JD, Smith S, Drinkard B, Sachdev V, Skarulis MC, Kozlosky M, Csako G, Costello R, Pucino F. (2011). Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab 96: 3466-3474
31. Appelhof BC, Fliers E, Wekking EM, Schene AH, Huyser J, Tijssen JG, Endert E, van Weert HC, Wiersinga WM. (2005). Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. J Clin Endocrinol Metab 90: 2666-2674
32. Bunevicius R, Jakuboniene N, Jurkevicius R, Cernicat J, Lasas L, Prange AJ Jr. (2002). Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves? disease. Endocrine 18: 129-133
33. Clyde PW, Harari AE, Getka EJ, Shakir KM. (2003). Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. JAMA 290: 2952-2958
34. Escobar-Morreale HF, Botella-Carretero JI, Gómez-Bueno M, Galán JM, Barrios V, Sancho J. (2005). Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-Thyroxine plus liothyronine with L-Thyroxine alone. Ann Intern Med 142: 412-424
35. Nygaard B, Jensen EW, Kvetny J, Jarløv A, Faber J. (2009). Effect of combination therapy with thyroxine (T4) and 3, 5, 3¢-Triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study. Eur J Endocrinol 161: 895-902
36. Rodriguez T, Lavis VR, Meininger JC, Kapadia AS, Stafford LF. (2005). Substitution of liothyronine at a 1: 5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. Endocr Pract 11: 223-233
37. Saravanan P, Simmons DJ, Greenwood R, Peters TJ, Dayan CM. (2005). Partial substitution of thyroxine (T4) with triiodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial. J Clin Endocrinol Metab 90: 805-812
38. Valizadeh M, Seyyed-Majidi MR, Hajibeigloo H, Momtazi S, Musavinasab N, Hayatbakhsh MR. (2009). Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: a randomized controlled trial. Endocr Res 34: 80-89
39. Walsh JP, Shiels L, Lim EM, Bhagat CI, Ward LC, Stuckey BG, Dhaliwal SS, Chew GT, Bhagat MC, Cussons AJ. (2003). Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J Clin Endocrinol Metab 88: 4543-4550
40. Garin MC, Arnold AM, Lee JS, Tracy RP, Cappola AR. (2014). Subclinical hypothyroidism, weight change, and body composition in the elderly: the Cardiovascular Health Study. J Clin Endocrinol Metab 99: 1220-1226
41. Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, Jørgensen T. (2005). Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 90: 4019-4024
42. Nyrnes A, Jorde R, Sundsfjord J. (2006). Serum TSH is positively associated with BMI. Int J Obes (Lond) 30: 100-105
43. Svare A, Nilsen TI, Bjøro T, Asvold BO, Langhammer A. (2011). Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway. Clin Endocrinol (Oxf) 74: 769-775
44. Fox CS, Pencina MJ, D'Agostino RB, Murabito JM, Seely EW, Pearce EN, Vasan RS. (2008). Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med 168: 587-592
45. Soriguer F, Valdes S, Morcillo S, Esteva I, Almaraz MC, de Adana MS, Tapia MJ, Dominguez M, Gutierrez-Repiso C, Rubio-Martin E, Garrido-Sanchez L, Perez V, Garriga MJ, Rojo-Martinez G, Garcia-Fuentes E. (2011). Thyroid hormone levels predict the change in body weight: a prospective study. Eur J Clin Invest 41: 1202-1209
46. Agnihothri RV, Courville AB, Linderman JD, Smith S, Brychta R, Remaley A, Chen KY, Simchowitz L, Celi FS. (2014). Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion. Thyroid 24: 19-26
47. Langdahl BL, Loft AG, Eriksen EF, Mosekilde L, Charles P. (1996). Bone mass, bone turnover and body composition in former hypothyroid patients receiving replacement therapy. Eur J Endocrinol 134: 702-709
48. Weinreb JT, Yang Y, Braunstein GD. (2011). Do patients gain weight after thyroidectomy for thyroid cancer? Thyroid 21: 1339-1342
49. Jonklaas J, Nsouli-Maktabi H. (2011). Weight changes in euthyroid patients undergoing thyroidectomy. Thyroid 21: 1343-1351