Effect of short-term thyroxine administration on energy metabolism and mitochondrial efficiency in humans

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Johannsen, Darcy L ^a   Galgani, Jose E ^a,b   Johannsen, Neil M ^a   Zhang, Zhengyu ^a   Covington, Jeffrey D ^a   Ravussin, Eric ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; LEVOTHYROXINE SODIUM; LIOTHYRONINE; THYROTROPIN; THYROXINE; UNCOUPLING PROTEIN 3;

ACUTE DRUG ADMINISTRATION; ADULT; ARTICLE; BODY COMPOSITION; CALORIMETRY; CELLULAR PARAMETERS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENERGY EXPENDITURE; ENERGY METABOLISM; ENZYME METABOLISM; EXERCISE; HORMONAL THERAPY; HORMONE BINDING; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; MALE; METABOLIC RATE; MITOCHONDRIAL COUPLING; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NORMAL HUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; REST; RESTING METABOLIC RATE; THYROID BINDING CAPACITY;

ADULT; BASAL METABOLISM; ENERGY METABOLISM; EXERCISE; HUMANS; MALE; MITOCHONDRIA; THYROXINE; TIME FACTORS;

EID: 84864392492     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040837     Document Type: Article

References (33)

1. Leonard JL, Koehrle L, (1996) Intracellular pathways of iodothyronine metabolism. In: Braverman LE, Utiger RD, editors. pp. 125-161 editors. Werner and Ingbar's the thyroid: a fundamental and clinical text. Philadelphia: Lippincott-Raven.
2. Dimitriadis G, Baker B, Marsh H, Mandarino L, Rizza R, et al. (1985) Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans. Am J Physiol 248: E593-601.
3. Lovejoy JC, Smith SR, Bray GA, DeLany JP, Rood JC, et al. (1997) A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men. J Clin Endocrinol Metab 82: 765-770.
4. Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, et al. (2001) Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest 108: 733-737.
5. Izmail-Beigi F, Edelman IS, (1970) Mechanism of thyroid calorigenesis: role of active sodium transport. Proc Natl Acad Sci U S A 67: 1071-1078.
6. Newsholme EA, Crabtree B, (1976) Substrate cycles in metabolic regulation and in heat generation. Biochem Soc Symp pp. 61-109.
7. Shulman GI, Ladenson PW, Wolfe MH, Ridgway EC, Wolfe RR, (1985) Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man. J Clin Invest 76: 757-764.
8. Gustafsson R, Tata JR, Lindberg O, Ernster L, (1965) The relationship between the structure and activity of rat skeletal muscle mitochondria after thyroidectomy and thyroid hormone treatment. J Cell Biol 26: 555-578.
9. Wiersinga WM, (2001) Thyroid hormone replacement therapy. Horm Res 56: 74-81.
10. Smith RN, Taylor SA, Massey JC, (1970) Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism. Br Med J 4: 145-148.
11. Bunevicius R, Kazanavicius G, Zalinkevicius R, Prange AJ Jr, (1999) Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 340: 424-429.
12. Kaptein EM, Beale E, Chan LS, (2009) Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. J Clin Endocrinol Metab 94: 3663-3675.
13. al-Adsani H, Hoffer LJ, Silva JE, (1997) Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. The Journal of clinical endocrinology and metabolism 82: 1118-1125.
14. Harper ME, Seifert EL, (2008) Thyroid hormone effects on mitochondrial energetics. Thyroid: official journal of the American Thyroid Association 18: 145-156.
15. Ladenson PW, Goldenheim PD, Cooper DS, Miller MA, Ridgway EC, (1982) Early peripheral responses to intravenous L-thyroxine in primary hypothyroidism. The American journal of medicine 73: 467-474.
16. Piolino V, Acheson KJ, Muller MJ, Jeanpretre N, Burger AG, et al. (1990) Thermogenic effect of thyroid hormones: interactions with epinephrine and insulin. The American journal of physiology 259: E305-311.
17. Bracco D, Morin O, Liang H, Jequier E, Burger AG, et al. (1996) Changes in sleeping and basal energy expenditure and substrate oxidation induced by short term thyroxin administration in man. Obes Res 4: 213-219.
18. Dubois S, Abraham P, Rohmer V, Rodien P, Audran M, et al. (2008) Thyroxine therapy in euthyroid patients does not affect body composition or muscular function. Thyroid: official journal of the American Thyroid Association 18: 13-19.
19. Clement K, Viguerie N, Diehn M, Alizadeh A, Barbe P, et al. (2002) In vivo regulation of human skeletal muscle gene expression by thyroid hormone. Genome research 12: 281-291.
20. Dubois S, Abraham P, Rohmer V, Rodien P, Audran M, et al. (2008) Thyroxine therapy in euthyroid patients does not affect body composition or muscular function. Thyroid 18: 13-19.
21. Ladenson PW, Goldenheim PD, Cooper DS, Miller MA, Ridgway EC, (1982) Early peripheral responses to intravenous L-thyroxine in primary hypothyroidism. Am J Med 73: 467-474.
22. Mogensen M, Sahlin K, Fernstrom M, Glintborg D, Vind BF, et al. (2007) Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes 56: 1592-1599.
23. Nannipieri M, Cecchetti F, Anselmino M, Camastra S, Niccolini P, et al. (2009) Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss. International journal of obesity 33: 1001-1006.
24. Knudsen N, Laurberg P, Rasmussen LB, Bulow I, Perrild H, et al. (2005) Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. The Journal of clinical endocrinology and metabolism 90: 4019-4024.
25. Redman LM, Heilbronn LK, Martin CK, de Jonge L, Williamson DA, et al. (2009) Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS One 4: e4377.
26. Jubrias SA, Esselman PC, Price LB, Cress ME, Conley KE, (2001) Large energetic adaptations of elderly muscle to resistance and endurance training. J Appl Physiol 90: 1663-1670.
27. Amara CE, Marcinek DJ, Shankland EG, Schenkman KA, Arakaki LS, et al. (2008) Mitochondrial function in vivo: spectroscopy provides window on cellular energetics. Methods 46: 312-318.
28. Amara CE, Shankland EG, Jubrias SA, Marcinek DJ, Kushmerick MJ, et al. (2007) Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proc Natl Acad Sci U S A 104: 1057-1062.
29. Conley KE, Blei ML, Richards TL, Kushmerick MJ, Jubrias SA, (1997) Activation of glycolysis in human muscle in vivo. Am J Physiol 273: C306-315.
30. Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, et al. (2001) Java-based graphical user interface for the MRUI quantitation package. Magma 12: 141-152.
31. Bergstrom J, (1975) Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35: 609-616.
32. Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, et al. (2010) Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle. Diabetes 59: 2444-2452.
33. Gaesser GA, Brooks GA, (1975) Muscular efficiency during steady-rate exercise: effects of speed and work rate. J Appl Physiol 38: 1132-1139.