Effects of Vitamin D binDing protein phenotypes and Vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D

European Journal of Endocrinology

Volumn 174, Issue 4, 2016, Pages 445-452

  Sollid, Stina T ^a,b   Hutchinson, Moira Y S ^a,c   Berg, Vivian ^b   Fuskevåg, Ole M ^b   Figenschau, Yngve ^a,b   Thorsby, Per M ^d   Jorde, Rolf ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c NORDLAND HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

COLECALCIFEROL; VITAMIN D BINDING PROTEIN; 25-HYDROXYVITAMIN D; PROTEIN BINDING; VITAMIN D;

ADULT; AGE; AGED; ARTICLE; BIOAVAILABILITY; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; FEMALE; GENDER; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMMUNOPHENOTYPING; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; DIETARY SUPPLEMENT; GENETIC ASSOCIATION STUDY; GENETICS; METABOLISM; MIDDLE AGED; VITAMIN D DEFICIENCY;

AGED; DIETARY SUPPLEMENTS; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDIABETIC STATE; PROTEIN BINDING; VITAMIN D; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN;

EID: 84962491849     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-15-1089     Document Type: Article

References (36)

1. Chun RF. New perspectives on the vitamin D binDing protein. Cell Biochemistry and Function 2012 30 445-456. (doi:10.1002/cbf.2835)
2. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E & Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binDing protein. Journal of Clinical Endocrinology and Metabolism 1986 63 954-959. (doi:10.1210/ jcem-63-4-954)
3. Chun RF, Peercy BE, Orwoll ES, Nielson CM, Adams JS & Hewison M. Vitamin D and DBP: the free hormone hypothesis revisited. Journal of Steroid Biochemistry and Molecular Biology 2014 144 132-137. (doi:10.1016/j.jsbmb.2013.09.012)
4. Speeckaert M, Huang G, Delanghe JR & Taes YE. Biological and clinical aspects of the vitamin D binDing protein (Gc-globulin) and its polymorphism. Clinica Chimica Acta 2006 372 33-42. (doi:10.1016/ j.cca.2006.03.011)
5. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA & Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver International 2015 35 2294-2300. (doi:10.1111/liv.12819)
6. Bouillon R, Van Assche FA, Van Baelen H, Heyns W & De Moor P. Influence of the vitamin D-binDing protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration. Journal of Clinical Investigation 1981 67 589-596. (doi:10.1172/JCI110072)
7. Moller UK, Streym S, Jensen LT, Mosekilde L, Schoenmakers I, Nigdikar S & Rejnmark L. Increased plasma concentrations of vitamin D metabolites and vitamin D binDing protein in women using hormonal contraceptives: a cross-sectional study. Nutrients 2013 5 3470-3480. (doi:10.3390/nu5093470)
8. Braun A, Bichlmaier R & Cleve H. Molecular analysis of the gene for the human vitamin-D-binDing protein (group-specific component): allelic differences of the common genetic GC types. Human Genetics 1992 89 401-406. (doi:10.1007/BF00194311)
9. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA et al. Vitamin D-binDing protein and vitamin D status of black Americans and white Americans. New England Journal of Medicine 2013 369 1991-2000. (doi:10.1056/ NEJMoa1306357)
10. O'Connor MY, Thoreson CK, Ramsey NL, Ricks M & Sumner AE. The uncertain significance of low vitamin D levels in African descent populations: a review of the bone and cardiometabolic literature. Progress in Cardiovascular Diseases 2013 56 261-269. (doi:10.1016/ j.pcad.2013.10.015)
11. Aloia J,MikhailM, Dhaliwal R, Shieh A, Usera G, Stolberg A, Ragolia L & Islam S. Free 25(OH)D and the vitamin D paradox in African Americans. Journal of Clinical Endocrinology and Metabolism 2015 100 3356-3363. (doi:10.1210/JC.2015-2066)
12. Glendenning P, Chew GT, Inderjeeth CA, Taranto M & Fraser WD. Calculated free and bioavailable vitamin D metabolite concentrations in vitamin D-deficient hip fracture patients after supplementation with cholecalciferol and ergocalciferol. Bone 2013 56 271-275. (doi:10.1016/ j.bone.2013.06.012)
13. Ponda MP, McGee D & Breslow JL. Vitamin D-binDing protein levels do not influence the effect of vitaminDrepletion on serumPTHand calcium: data from a randomized, controlled trial. Journal of Clinical Endocrinology and Metabolism 2014 99 2494-2499. (doi:10.1210/jc.2014-1181)
14. Sollid ST, Hutchinson MY, Fuskevag OM, Figenschau Y, Joakimsen RM, Schirmer H, Njolstad I, Svartberg J, Kamycheva E & Jorde R. No effect of high-dose vitamin D supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes. Diabetes Care 2014 37 2123-2131. (doi:10.2337/dc14-0218)
15. Hutchinson MS, Grimnes G, Joakimsen RM, Figenschau Y & Jorde R. Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromso study. European Journal of Endocrinology/European Federation of Endocrine Societies 2010 162 935-942. (doi:10.1530/EJE-09-1041)
16. Maunsell Z, Wright DJ & Rainbow SJ. Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3. Clinical Chemistry 2005 51 1683-1690. (doi:10.1373/clinchem.2005. 052936)
17. Kauppinen-Makelin R, Tahtela R, Loyttyniemi E, Karkkainen J & Valimaki MJ. A high prevalence of hypovitaminosis D in Finnish medical in-and outpatients. Journal of Internal Medicine 2001 249 559-563. (doi:10.1046/j.1365-2796.2001.00847.x)
18. Vermeulen A, Verdonck L & Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism 1999 84 3666-3672. (doi:10.1210/jcem.84.10.6079)
19. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R & Bhan I. Vitamin D-binDing protein modifies the vitamin D-bone mineral density relationship. Journal of Bone and Mineral Research 2011 26 1609-1616. (doi:10.1002/ jbmr.387)
20. Lauridsen AL, Vestergaard P, Hermann AP, Brot C, Heickendorff L, Mosekilde L & Nexo E. Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binDing protein): a cross-sectional study on 595 early postmenopausal women. Calcified Tissue International 2005 77 15-22. (doi:10.1007/s00223-004-0227-5)
21. Lauridsen AL, Vestergaard P & Nexo E. Mean serum concentration of vitamin D-binDing protein (Gc globulin) is related to the Gc phenotype in women. Clinical Chemistry 2001 47 753-756. (doi:10.1007/s00223-004-0227-5)
22. Johnsen MS, Grimnes G, Figenschau Y, Torjesen PA, Almas B & Jorde R. Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D. Scandinavian Journal of Clinical and Laboratory Investigation 2014 74 177-183. (doi:10.3109/00365513.2013.869701)
23. Taes YE, Goemaere S, Huang G, Van Pottelbergh I, De Bacquer D, Verhasselt B, Van den Broeke C, Delanghe JR & Kaufman JM. Vitamin D binDing protein, bone status and body composition in communitydwelling elderly men. Bone 2006 38 701-707. (doi:10.1016/j.bone. 2005.10.006)
24. Powe CE, Karumanchi SA & Thadhani R. Vitamin D-binDing protein and vitamin D in blacks and whites. New England Journal of Medicine 2014 370 880-881. (doi:10.1056/NEJMc1315850)
25. Bolland MJ, Grey AB, Ames RW, Horne AM, Mason BH, Wattie DJ, Gamble GD, Bouillon R & Reid IR. Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binDing protein. Clinical Endocrinology 2007 67 259-264. (doi:10.1111/ j.1365-2265.2007.02873.x)
26. Karlsson T, Osmancevic A, Jansson N, Hulthen L, Holmang A & Larsson I. Increased vitamin D-binDing protein and decreased free 25(OH)D in obese women of reproductive age. European Journal of Nutrition 2014 53 259-267. (doi:10.1007/s00394-013-0524-8)
27. Winters SJ, Chennubhatla R, Wang C & Miller JJ. Influence of obesity on vitamin D-binDing protein and 25-hydroxy vitamin D levels in African American and white women. Metabolism: Clinical and Experimental 2009 58 438-442. (doi:10.1016/j.metabol.2008.10.017)
28. Jorde R, Figenschau Y, Emaus N, Hutchinson M & Grimnes G. Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension. Hypertension 2010 55 792-798. (doi:10.1161/HYPERTENSIONAHA.109.143990)
29. Sollid ST, Hutchinson MY, Fuskevag OM, Joakimsen RM & Jorde R. Large individual differences in serum25-hydroxyvitaminD response to vitamin D supplementation: effects of genetic factors, body mass index, and baseline concentration. Results from a randomized controlled trial. Hormone and Metabolic Research, 2015. In press. (doi:10.1055/s-0034-1398617)
30. Arnaud J & Constans J. Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Human Genetics 1993 92 183-188. (doi:10.1007/BF00219689)
31. Seamans KM & Cashman KD. Existing and potentially novel functional markers of vitamin D status: a systematic review. American Journal of Clinical Nutrition 2009 89 1997s-2008s. (doi:10.3945/ajcn.2009.27230D)
32. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N & Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. Journal of Clinical Endocrinology and Metabolism 2014 99 1631-1637. (doi:10.1210/jc.2013-3874)
33. Aloia J, Dhaliwal R, MikhailM, Shieh A, Stolberg A, Ragolia L, FazzariM & Abrams SA. Free 25(OH)D and calcium absorption, PTH and markers of bone turnover. Journal of Clinical Endocrinology and Metabolism 2015 100 4140-4145. (doi:10.1210/jc.2015-2548)
34. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI & Willnow TE. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999 96 507-515. (doi:10.1016/S0092-8674(00)80655-8)
35. Sonderman JS, Munro HM, Blot WJ & Signorello LB. Reproducibility of serum 25-hydroxyvitamin d and vitamin D-binDing protein levels over time in a prospective cohort study of black and white adults. American Journal of Epidemiology 2012 176 615-621. (doi:10.1093/aje/kws141)
36. Ekins R. The free hormone hypothesis and measurement of free hormones. Clinical Chemistry 1992 38 1289-1293.