Free 25(OH)D and calcium absorption, PTH, and markers of bone turnover

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 11, 2015, Pages 4140-4145

  Aloia, John ^a   Dhaliwal, Ruban ^a   Mikhail, Mageda ^a   Shieh, Albert ^a   Stolberg, Alexandra ^a   Ragolia, Louis ^a   Fazzari, Melissa ^a   Abrams, Steven A ^a  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; COLECALCIFEROL; PARATHYROID HORMONE; PEPTIDE DERIVATIVE; PLACEBO; PROCOLLAGEN; PROCOLLAGEN TYPE 1 N TERMINAL PROPEPTIDE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; COLLAGEN TYPE 1; HYDROXYCOLECALCIFEROL; VITAMIN;

25 HYDROXYVITAMIN D BLOOD LEVEL; ADULT; AMBULATORY CARE; ARTICLE; BONE TURNOVER; CALCIUM ABSORPTION; CARBOXY TERMINAL TELOPEPTIDE BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MEDICAL RESEARCH; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TEACHING HOSPITAL; VITAMIN BLOOD LEVEL; AGED; BLOOD; BONE; BONE REMODELING; FEMALE; MALE; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; AGED; BIOMARKERS; BONE AND BONES; BONE REMODELING; CALCIUM; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYDROXYCHOLECALCIFEROLS; MALE; MIDDLE AGED; PARATHYROID HORMONE; VITAMINS; YOUNG ADULT;

EID: 84958550528     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2548     Document Type: Article

References (16)

1. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986;63(4):954-959.
2. Chun RF, Peercy BE, Orwoll ES, Nielson CM, Adams JS, Hewison M. Vitamin D and DBP: the free hormone hypothesis revisited. J Steroid Biochem Mol Biol. 2014;144:132-137.
3. PoweCE, EvansMK,Wenger J, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369(21):1991-2000.
4. Aloia JF. African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox. Am J Clin Nutr. 2008;88(2):545S-550S.
5. Ponda MP, McGee D, Breslow JL. Vitamin D-binding protein levels do not influence the effect of vitaminDrepletion on serum PTH and calcium: data from a randomized, controlled trial. J Clin Endocrinol Metab. 2014;99(7):2494-2499.
6. Aloia JF, Dhaliwal R, Shieh A, et al. Vitamin D supplementation increases calcium absorption without a threshold effect. Am J Clin Nutr. 2014;99(3):624-631.
7. Abrams SA. Using stable isotopes to assess mineral absorption and utilization by children. Am J Clin Nutr. 1999;70(6):955-964.
8. Griffin IJ, Abrams SA. Methodological considerations in measuring human calcium absorption: relevance to study the effects of inulintype fructans. Br J Nutr. 2005;93(suppl 1):S105-S110.
9. Abrams SA, Griffin IJ, Hawthorne KM, Gunn SK, Gundberg CM, Carpenter TO. Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. J Clin Endocrinol Metab. 2005;90(10):5576-5581.
10. Abrams SA, Copeland KC, Gunn SK, Stuff JE, Clarke LL, Ellis KJ. Calcium absorption and kinetics are similar in 7-and 8-year-old Mexican-American and Caucasian girls despite hormonal differences. J Nutr. 1999;129(3):666-671.
11. Abrams SA, Copeland KC,GunnSK, GundbergCM,KleinKO,Ellis KJ. Calcium absorption, bone mass accumulation, and kinetics increase during early pubertal development in girls. J Clin Endocrinol Metab. 2000;85(5):1805-1809.
12. Schwartz JB, Lai J, Lizaola B, et al. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014;99(5):1631-1637.
13. Schwartz JB, Lai J, Lizaola B, et al. Variability in free 25(OH) vitamin D levels in clinical populations. J Steroid Biochem Mol Biol. 2014;144:156-158.
14. Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitaminDlevels. J Clin Invest. 1986;78(3): 748-752.
15. Bikle DD, Gee E, Halloran B, Haddad JG. Free 1,25-dihydroxyvitaminDlevels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest. 1984;74(6):1966-1971.
16. Manson, J.E. and S.S. Bassuk. VitaminDresearch and clinical practice: at a crossroads. JAMA. 2015;313(13):1311-1312.