Calculated free and bioavailable vitamin D metabolite concentrations in vitamin D-deficient hip fracture patients after supplementation with cholecalciferol and ergocalciferol

Bone

Volumn 56, Issue 2, 2013, Pages 271-275

  Glendenning, Paul ^a,b,c   Chew, Gerard T ^b   Inderjeeth, Charles A ^b,d   Taranto, Mario ^a   Fraser, William D ^e  

^a ROYAL PERTH HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d North Metropolitan Area Health Service   (Australia)

^e UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Calculated free vitamin D concentrations; Cholecalciferol; Ergocalciferol; Hip fracture; Vitamin D binding protein

Indexed keywords

ALBUMIN; BROMOCRESOL GREEN; CALCITRIOL; CALCIUM ION; COLECALCIFEROL; ERGOCALCIFEROL; PARATHYROID HORMONE; PLACEBO; VITAMIN D BINDING PROTEIN;

ADULT; ARTICLE; BLOOD ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIP FRACTURE; HUMAN; ION SELECTIVE ELECTRODE; MAJOR CLINICAL STUDY; NEPHELOMETRY; PATIENT COMPLIANCE; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME; VITAMIN D DEFICIENCY;

CALCULATED FREE VITAMIN D CONCENTRATIONS; CHOLECALCIFEROL; ERGOCALCIFEROL; HIP FRACTURE; VITAMIN D-BINDING PROTEIN;

AGED; AGED, 80 AND OVER; CHOLECALCIFEROL; ERGOCALCIFEROLS; FEMALE; HIP FRACTURES; HUMANS; MALE; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84880380294     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.06.012     Document Type: Article

References (31)

1. Lips P. Vitamin D, deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001, 22:477-501.
2. Glendenning P., Chew G.T., Seymour H.M., Gillett M.J., Goldswain P.R., Inderjeeth C.A., et al. Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone 2009, 45:870-875.
3. Romagnoli E., Mascia M.L., Cipriani C., Fassino V., Mazzei F., D'Erasmo E., et al. Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab 2008, 93:3015-3020.
4. Armas L.A., Hollis B.W., Heaney R.P. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab 2004, 89:5387-5391.
5. Trang H.M., Cole D.E., Rubin L.A., Pierratos A., Siu S., Vieth R. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 1998, 68:854-858.
6. Tripkovic L., Lambert H., Hart K., Smith C.P., Bucca G., Penson S., et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr 2012, 95:1357-1364.
7. Logan V.F., Gray A.R., Peddie M.C., Harper M.J., Houghton L.A. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr 2012, 1-7.
8. Tang E.K., Voo K.J., Nguyen M.N., Tuckey R.C. Metabolism of substrates incorporated into phospholipid vesicles by mouse 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1). J Steroid Biochem Mol Biol 2010, 119:171-179.
9. Bouillon R., Van Baelen H. Transport of vitamin D: significance of free and total concentrations of the vitamin D metabolites. Calcif Tissue Int 1981, 33:451-453.
10. Safadi F.F., Thornton P., Magiera H., Hollis B.W., Gentile M., Haddad J.G., et al. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest 1999, 103:239-251.
11. Al-oanzi Z.H., Tuck S.P., Raj N., Harrop J.S., Summers G.D., Cook D.B., et al. Assessment of vitamin D status in male osteoporosis. Clin Chem 2006, 52:248-254.
12. Bouillon R., Van Assche F.A., Van Baelen H., Heyns W., De Moor P. Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration. J Clin Invest 1981, 67:589-596.
13. Powe C.E., Ricciardi C., Berg A.H., Erdenesanaa D., Collerone G., Ankers E., et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res 2011, 26:1609-1616.
14. Glendenning P., Taranto M., Noble J.M., Musk A.A., Hammond C., Goldswain P.R., et al. Current assays overestimate 25-hydroxyvitamin D3 and underestimate 25-hydroxyvitamin D2 compared with HPLC: need for assay-specific decision limits and metabolite-specific assays. Ann Clin Biochem 2006, 43:23-30.
15. Boudville N., Inderjeeth C., Elder G.J., Glendenning P. Association between 25-hydroxyvitamin D, somatic muscle weakness and falls risk in end-stage renal failure. Clin Endocrinol 2010, 73:299-304.
16. Bikle D.D., Gee E., Halloran B., Kowalski M.A., Ryzen E., Haddad J.G. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 1986, 63:954-959.
17. Schlingmann K.P., Kaufmann M., Weber S., Irwin A., Goos C., John U., et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med 2011, 365:410-421.
18. Dauber A., Nguyen T.T., Sochett E., Cole D.E., Horst R., Abrams S.A., et al. Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia. J Clin Endocrinol Metab 2012, 97:E268-E274.
19. Horst R.L., Reinhardt T.A., Ramberg C.F., Koszewski N.J., Napoli J.L. 24-Hydroxylation of 1,25-dihydroxyergocalciferol. An unambiguous deactivation process. J Biol Chem 1986, 261:9250-9256.
20. Houghton L.A., Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr 2006, 84:694-697.
21. van Hoof H.J., Swinkels L.M., Ross H.A., Sweep C.G., Benraad T.J. Determination of non-protein-bound plasma 1,25-dihydroxyvitamin D by symmetric (rate) dialysis. Anal Biochem 1998, 258:176-183.
22. Vieth R. Simple method for determining specific binding capacity of vitamin D-binding protein and its use to calculate the concentration of "free" 1,25-dihydroxyvitamin D. Clin Chem 1994, 40:435-441.
23. Hartwell D., Hassager C., Christiansen C. Effect of vitamin D2 and vitamin D3 on the serum concentrations of 1,25(OH)2D2, and 1,25(OH)2D3 in normal subjects. Acta Endocrinol 1987, 115:378-384.
24. Biancuzzo R.M., Clarke N., Reitz R.E., Travison T.G., Holick M.F. Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation. J Clin Endocrinol Metab 2013, 98:973-979.
25. Turner C., Dalton N., Inaoui R., Fogelman I., Fraser W.D., Hampson G. Effect of a 300000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency. J Clin Endocrinol Metab 2013, 98:550-556.
26. Meier U., Gressner O., Lammert F., Gressner A.M. Gc-globulin: roles in response to injury. Clin Chem 2006, 52:1247-1253.
27. Lips P., Bouillon R., Jongen M.J., van Ginkel F.C., van der Vijgh W.J., Netelenbos J.C. The effect of trauma on serum concentrations of vitamin D metabolites in patients with hip fracture. Bone 1985, 6:63-67.
28. Fu L., Yun F., Oczak M., Wong B.Y., Vieth R., Cole D.E. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem 2009, 42:1174-1177.
29. Perna L., Felix J.F., Breitling L.P., Haug U., Raum E., Burwinkel B., et al. Genetic variations in the vitamin d binding protein and season-specific levels of vitamin d among older adults. Epidemiology 2013, 24:104-109.
30. Holmberg I., Berlin T., Ewerth S., Bjorkhem I. 25-Hydroxylase activity in subcellular fractions from human liver. Evidence for different rates of mitochondrial hydroxylation of vitamin D2 and D3. Scand J Clin Lab Invest 1986, 46:785-790.
31. Whyte M.P., Haddad J.G., Walters D.D., Stamp T.C. Vitamin D bioavailability: serum 25-hydroxyvitamin D levels in man after oral, subcutaneous, intramuscular, and intravenous vitamin D administration. J Clin Endocrinol Metab 1979, 48:906-911.