Pancreatic β-cell adaptive plasticity in obesity increases insulin production but adversely affects secretory function

Diabetes

Volumn 65, Issue 2, 2016, Pages 438-450

  Alarcon, Cristina ^a   Boland, Brandon B ^a   Uchizono, Yuji ^a   Moore, Patrick C ^a   Peterson, Bryan ^a   Rajan, Suryalekha ^a   Rhodes, Olivia S ^a   Noske, Andrew B ^b   Haataja, Leena ^c   Arvan, Peter ^c   Marsh, Bradly J ^b   Austin, Jotham ^d   Rhodes, Christopher J ^a  

^a University of Chicago ^*  (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; MESSENGER RNA; PREPROINSULIN; PROINSULIN; PROTEIN; GLUCOSE BLOOD LEVEL; VESICULAR TRANSPORT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; CELL HETEROGENEITY; CELL PLASTICITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GOLGI COMPLEX; IN VITRO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; MITOCHONDRIAL VOLUME; MOUSE; MULTIVESICULAR BODY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; ROUGH ENDOPLASMIC RETICULUM; TRANS GOLGI NETWORK; ANIMAL; BIOSYNTHESIS; COMPLICATION; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; GLUCOSE BLOOD LEVEL; METABOLISM; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; BLOOD GLUCOSE; CELL PLASTICITY; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; INSULIN-SECRETING CELLS; MICE; OBESITY; PROINSULIN; VESICULAR TRANSPORT PROTEINS;

EID: 84962463488     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0792     Document Type: Article

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