Islet transplantation for type 1 diabetes, 2015: What have we learned from alloislet and autoislet successes?

Diabetes Care

Volumn 38, Issue 6, 2015, Pages 1030-1035

  Robertson, R Paul ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; ANTIDIABETIC AGENT; INSULIN;

ALLOTRANSPLANTATION; ARTICLE; AUTOTRANSPLANTATION; CHRONIC PANCREATITIS; CLINICAL EFFECTIVENESS; GRAFT REJECTION; HISTORY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; ISOLATION PROCEDURE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PANCREAS RESECTION; QUALITY OF LIFE; ADVERSE EFFECTS; DIABETES MELLITUS, TYPE 1; PANCREATITIS, CHRONIC; PHYSIOLOGY; PROCEDURES; TRANSPLANTATION; TREATMENT OUTCOME;

DIABETES MELLITUS, TYPE 1; GLUCAGON-SECRETING CELLS; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOSUPPRESSIVE AGENTS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; PANCREATECTOMY; PANCREATITIS, CHRONIC; TISSUE AND ORGAN PROCUREMENT; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84962447619     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-0079     Document Type: Article

References (40)

1. Sutherland DE, Matas AJ, Najarian JS. Pancreatic islet cell transplantation. Surg Clin North Am 1978;58:365-382.
2. Najarian JS, Sutherland DE, Baumgartner D, et al. Total or near total pancreatectomy and islet autotransplantation for treatment of chronic pancreatitis. Ann Surg 1980;192:526- 542.
3. Williams P. Notes on diabetes treated with extract and by grafts of sheep's pancreas. BMJ 1894;12:1303-1304.
4. Largiader F, Kolb E, Binswanger U. A longterm functioning human pancreatic islet allotransplant. Transplantation 1980;29:76-77.
5. Scharp DW, Lacy PE, Santiago JV, et al. Insulin independence after islet transplantation into type I diabetic patient. Diabetes 1990;39: 515-518.
6. Tzakis AG, Ricordi C, Alejandro R, et al. Pancreatic islet transplantation after upper abdominal exenteration and liver replacement. Lancet 1990;336:402-405.
7. Warnock GL, Kneteman NM, Ryan E, Seelis RE, Rabinovitch A, Rajotte RV. Normoglycaemia after transplantation of freshly isolated and cryopreserved pancreatic islets in type 1 (insulindependent) diabetes mellitus. Diabetologia 1991;34:55-58.
8. Scharp DW, Lacy PE, Santiago JV, et al. Results of our first nine intraportal islet allografts in type 1, insulin-dependent diabetic patients. Transplantation 1991;51:76-85.
9. Warnock GL, Kneteman NM, Ryan EA, Rabinovitch A, Rajotte RV. Long-term followup after transplantation of insulin-producing pancreatic islets into patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992;35:89-95.
10. Gores PF, Najarian JS, Stephanian E, Lloveras JJ, Kelley SL, Sutherland DE. Insulin independence in type I diabetes after transplantation of unpurified islets from single donor with 15- deoxyspergualin. Lancet 1993;341:19-21.
11. Soon-Shiong P, Heintz RE, Merideth N, et al. Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet 1994;343:950-951.
12. Carroll PB, Rilo HL, Alejandro R, et al. Longterm (. 3-year) insulin independence in a patient with pancreatic islet cell transplantation following upper abdominal exenteration and liver replacement for fibrolamellar hepatocellular carcinoma. Transplantation 1995;59:875-879.
13. Luzi L, Hering BJ, Socci C, et al. Metabolic effects of successful intraportal islet transplantation in insulin-dependent diabetes mellitus. J Clin Invest 1996;97:2611-2618.
14. Alejandro R, Lehmann R, Ricordi C, et al. Long-term function (6 years) of islet allografts in type 1 diabetes. Diabetes 1997;46:1983-1989.
15. Secchi A, Socci C, Maffi P, et al. Islet transplantation in IDDM patients. Diabetologia 1997; 40:225-231.
16. Keymeulen B, Ling Z, Gorus FK, et al. Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 1998;41:452-459.
17. Oberholzer J, Triponez F, Mage R, et al. Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations. Transplantation 2000;69:1115-1123.
18. Wahoff DC, Papalois BE, Najarian JS, et al. Autologous islet transplantation to prevent diabetes after pancreatic resection. Ann Surg 1995;222:562-575; discussion 575-579.
19. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343:230-238.
20. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005;54:2060-2069.
21. Hering BJ, Kandaswamy R, Ansite JD, et al. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 2005;293:830-835.
22. Bellin MD, Kandaswamy R, Parkey J, et al. Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes. Am J Transplant 2008;8:2463-2470.
23. CITR Research Group. 2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR). Cell Transplant 2009;18:753-767.
24. Barton FB, Rickels MR, Alejandro R, et al. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care 2012;35: 1436-1445.
25. Rickels MR, Liu C, Shlansky-Goldberg RD, et al. Improvement in b-cell secretory capacity after human islet transplantation according to the CIT07 protocol. Diabetes 2013;62:2890- 2897.
26. Sutherland DE, Radosevich DM, Bellin MD, et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J Am Coll Surg 2012;214:409-424.
27. Clayton HA, Davies JE, Pollard CA, White SA, Musto PP, Dennison AR. Pancreatectomy with islet autotransplantation for the treatment of severe chronic pancreatitis: The first 40 patients at the leicester general hospital. Transplantation 2003;76:92-98.
28. Robertson RP. Islet transplantation as a treatment for diabetes - A work in progress. N Engl J Med 2004;350:694-705.
29. Shapiro AM, Gallant HL, Hao EG, et al. The portal immunosuppressive storm: relevance to islet transplantation? Ther Drug Monit 2005;27: 35-37.
30. Desai NM, Goss JA, Deng S, et al. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity? Transplantation 2003;76:1623-1625.
31. Teuscher AU, Kendall DM, Smets YF, Leone JP, Sutherland DE, Robertson RP. Successful islet autotransplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass. Diabetes 1998;47: 324-330.
32. Robertson RP, Bogachus LD, Oseid E, et al. Assessment of b-cell mass and a- And b-cell survival and function by arginine stimulation in human autologous islet recipients. Diabetes 2015;64:565-572.
33. Pyzdrowski KL, Kendall DM, Halter JB, Nakhleh RE, Sutherland DE, Robertson RP. Preserved insulin secretion and insulin independence in recipients of islet autografts. N Engl J Med 1992;327:220-226.
34. Kendall DM, Teuscher AU, Robertson RP. Defective glucagon secretion during sustained hypoglycemia following successful islet allo- And autotransplantation in humans. Diabetes 1997; 46:23-27.
35. Gupta V, Wahoff DC, Rooney DP, et al. The defective glucagon response from transplanted intrahepatic pancreatic islets during hypoglycemia is transplantation site-determined. Diabetes 1997;46:28-33.
36. Zhou H, Zhang T, Bogdani M, et al. Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia. Diabetes 2008;57:1567- 1574.
37. Paty BW, Ryan EA, Shapiro AM, Lakey JR, Robertson RP. Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 2002;51:3428-3434.
38. Rickels MR, Schutta MH, Mueller R, et al. Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes. Diabetes 2005;54:3205-3211.
39. Rickels MR, Fuller C, Dalton-Bakes C, et al. Restoration of glucose counterregulation by islet transplantation in long-standing type 1 diabetes. Diabetes 2015;64:1713-1718.
40. Bellin MD, Parazzoli S, Oseid E, et al. Defective glucagon secretion during hypoglycemia after intrahepatic but not nonhepatic islet autotransplantation. Am J Transplant 2014;14:1880- 1886.