Metabolic effects of successful intraportal islet transplantation in insulin-dependent diabetes mellitus

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2611-2618

  Luzi, Livio ^a   Hering, Bernhard J ^b   Socci, Carlo ^c   Raptis, George ^b   Battezzati, Alberto ^c   Terruzzi, Ileana ^c   Falqui, Luca ^c   Brandhorst, Heide ^b   Brandhorst, Daniel ^b   Regalia, Enrico ^d   Brambilla, Eugenia ^a   Secchi, Antonio ^c   Perseghin, Gianluca ^c   Maffi, Paola ^c   Bianchi, Elda ^c   Mazzaferro, Vincenzo ^d   Gennari, Leandro ^d   Di Carlo, Valerio ^c   Federlin, Konrad ^b   Pozza, Guido ^c   Bretzel, Reinhard G ^b   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY OF MILAN   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

glucose metabolism; hepatic glucose production; immunosuppressive therapy; insulin resistance; islet secretion

Indexed keywords

AZATHIOPRINE; C PEPTIDE; CYCLOSPORIN A; FATTY ACID; GLUCAGON; GLUCOSE; INSULIN; LACTIC ACID; PREDNISONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; KIDNEY GRAFT; LIVER METABOLISM; MALE; METABOLIC CLEARANCE RATE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL;

EID: 8944251633     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118710     Document Type: Article

References (27)

1. Luzi, L., E. Barrett, L.C. Group, E. Ferrannini, and R.A. De Fronzo. 1988. Metabolic effect of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis. Diabetes. 37:1470-1477.
2. Yki-Järvinen, H., and V. Koivisto. 1984. Continuous subcutaneous insulin infusion therapy decreases insulin resistance in Type 1 diabetes. J. Clin. Endocrinol. & Metab. 58:659-666.
3. May, R.C., A.S. Clark, A. Goheer, and W.E. Mitch. 1985. Specific defects in insulin-mediated glucose metabolism in acute uremia. Kidney Int. 28:490-497.
4. The Diabetes Control and Complications Trial Group. 1993. The effect of intensive treatment of diabetes in the development and progression of long-term complications of IDDM. N. Engl. J. Med. 329:977-986.
5. Sutherland, D.E.R., R.W.G. Gruessner, and R.F. Gores. 1994. Pancreas and islet transplantation: an update. Transplant. Rev. 8:185-206.
6. Secchi, A., J.M. Dubernard, E. La Rocca, M. Melandri, N. Lefrancois, X. Martin, J.L. Touraine, J. Traeger, and G. Pozza. 1991. Endocrine-metabolic effects of whole vs segmental pancreas allotransplantation in diabetic patients: a two years follow up. Transplantation (Baltimore). 51:625-629.
7. Groth, G.C., H. Collste, G. Lundgren, H. Wilczek, G. Klintmalm, O. Ringden, R. Gunnarsson, and J. Östman. 1982. Successful outcome of segmentai human pancreatic transplantation with enteric exocrine diversion after modification in technique. Lancet., ii:522-524.
8. Katz, H., M. Homan, J. Velosa, R.P. Robertson, and R. Rizza. 1991. Effects of pancreas transplantation on post-prandial glucose metabolism. N. Engl. J. Med. 325:1278-1284.
9. Elahi, D., B.A. Clark, M. McAlcon-Dyke, G. Wong, R. Brouri, M. Shapiro, K.L. Minaker, T.L. Flanagan, T. Purett, R. Gingerich, J. Hanks, and D.K. Andersen. 1991. Islet cell responses to glucose in human transplanted pancreas. Am. J. Physiol. 261:E800-E808.
10. Luzi, L., A. Secchi, F. Facchini, A. Battezzati, C. Staudacher, D. Spotti, R. Castoldi, G. Ferrari, V. Di Carlo, and G. Pozza. 1990. Reduction of insulin resistance by combined kidney-pancreas transplantation in type 1 (insulin-dependent) diabetic patients. Diabetologia. 33:549-556.
11. Cottrell, D.A., M.L. Henry, T.M. D'Orisio, R.J. Tesi, R.M. Ferguson, and K. Osei. 1991. Hypoglycemia after successful pancreas transplantation in Type I diabetic patients. Diabetes Care. 14:1111-1113.
12. Battezzati, A., L. Luzi, G. Perseghin, E. Bianchi, D. Spotti, A. Secchi, S. Vergani, V. Di Carlo, and G. Pozza. 1994. Persistence of counterregulatory abnormalities in insulin dependent diabetes mellitus after pancreas transplantation. Eur. J. Clin. Invest. 24:751-758.
13. Robertson, R.P. 1992. Pancreatic and islet transplantation for diabetes: cures or curiosities? N. Engl. J. Med. 327:1861-1869.
14. Luzi, L., and R.A. De Fronzo. 1989. Effect of the loss of first phase of insulin secretion on hepatic glucose production and tissue glucose disposal in humans. Am. J. Physiol. 257:E241-E246.
15. Wielko, J., and W.R. Sherman. 1976. Boroacetylation of carbohydrates. Correlations between structures and mass spectral behavior in monoacetylexoses cyclic boronic esters. J. Am. Chem. Soc. 98:7631-7637.
16. Glantz, S.A., and B.K. Slinker. 1990. Primer of Applied Regression of Analysis of Variance. McGraw Hill, Inc. New York. 1-777.
17. Luzi, L., A. Battezzati, G. Perseghin, E. Bianchi, S. Vergani, A. Secchi, E. La Rocca, C. Staudacher, D. Spotti, G. Ferrari et al. 1992. Lack of feed-back inhibition of insulin secretion in denervated human pancreas. Diabetes. 41: 1632-1639.
18. Scopsi, L., S. Andreola, C. Socci, F. Bertuzzi, V. Di Carlo, G. Pozza, F. Rilke, L. Gennari, G. Colella, E. Regalia, and V. Mazzaferro. 1994. Immunocytochemical detection and characterization of intrahepatic human pancreatic islets after combined liver-islet allotransplantation. Cell Transplant. 3:499-508.
19. Luzi, L., A. Secchi, and G. Pozza. 1992. Metabolic assessment of post-transplantation islet function in humans. Methodological considerations and possible pitfalls: a lesson from pancreas transplantation. In Pancreatic Islet Cell Transplantation. R. Ricordin, editor. Landes Co. 361-382.
20. Havel, P.J., and J.G. Taborsky 1989. The contribution of autonomie nervous system to changes of glucagon and insulin secretion during hypoglycemic stress. Endocrine Rev. 10:332-350.
21. Nielsen, J.H., T. Mandrup-Poulsen, and J. Nerup. 1986. Direct effects of cyclosporin A on human pancreatic β-cell. Diabetes. 35:1049-1052.
22. Laube, F., and H.J. Hahn. 1985. Effects of cyclosporin A on insulin secretion in vitro. Horm. Metab. Res. 17:43-44.
23. Korsgren, O., L. Jansson, A. Andersson, and F. Sundler. 1993. Reinnervation of transplanted pancreatic islet. A comparison among islet implanted into the kidney, spleen and liver. Transplantation (Baltimore). 56:1138-1143.
24. Menger, M.D., S. Jaeger, P. Walter, G. Feifel, F. Hammersen, and K. Messmer. 1989. Angiogenesis and hemodynamics of microvasculature of transplanted islet of Langerhans. Diabetes. 38:S1.
25. Hosker, J.P., M.A. Burnett, D.R. Matthews, and R.C. Turner. 1993. Prednisone enhances β-cell function independently of ambient glycemic levels in Type II diabetes. Metabolism. 42:1116-1120.
26. Mitrakou, A., D. Kelley, M. Mokan, T. Veneman, T. Pangburn, J. Reilly, and J. Gerich. 1992. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N. Engl. J. Med. 326:22-29.
27. Perseghin, G., H. Hilden, E. Bianchi, I. Terruzzi, A. Battezzati, and L. Luzi, 1993. Normal sensitivity of FFA metabolism despite resistance of glucose metabolism to insulin after pancreas transplantation. Diabetes. 43(S2): 138a.