Intrahepatic glucose flux as a mechanism for defective intrahepatic islet α-cell response to hypoglycemia

Diabetes

Volumn 57, Issue 6, 2008, Pages 1567-1574

  Zhou, Huarong ^a   Zhang, Tao ^a   Bogdani, Marika ^a   Oseid, Elizabeth ^a   Parazzoli, Susan ^a   Vantyghem, Marie Christine ^b   Harmon, Jamie ^a   Slucca, Michela ^a   Robertson, R Paul ^a,c  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLYCOGEN; STREPTOZOCIN; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL THERAPY; CELL TRANSPLANTATION; CONTROL GROUP; CONTROLLED STUDY; GLYCOGEN LIVER LEVEL; GLYCOGENOLYSIS; GRAFT RECIPIENT; HYPOGLYCEMIA; KIDNEY CAPSULE; LEWIS RAT; LIVER SINUSOID; LIVER TRANSPLANTATION; MALE; NONHUMAN; OMENTUM; PANCREAS ISLET ALPHA CELL; PERITONEAL CAVITY; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; ANIMAL; BLOOD; EXPERIMENTAL DIABETES MELLITUS; ISOGRAFT; LIVER; METABOLISM; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PHYSIOLOGY; SECRETION; TRANSPLANTATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; HYPOGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; LIVER; MALE; RATS; RATS, INBRED LEW; TRANSPLANTATION, ISOGENEIC;

EID: 48249088124     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0137     Document Type: Article

References (16)

1. Pyzdrowski KL, Kendall DM, Halter JB, Nakhleh RE, Sutherland DE, Robertson RP: Preserved insulin secretion and insulin independence in recipients of islet autografts. N Engl J Med 327:220-226, 1992
2. Kendall DM, Teuscher AU, Robertson RP: Defective glucagon secretion during sustained hypoglycemia following successful islet allo- and auto- transplantation in humans. Diabetes 46:23-27, 1997
3. Gupta V, Wahoff DC, Rooney DP, Poitout V, Sutherland DE, Kendall DM, Robertson RP: The defective glucagon response from transplanted intra- hepatic pancreatic islets during hypoglycemia is transplantation site- determined. Diabetes: 46:28-33, 1997
4. Paty BW, Ryan EA, Shapiro AM, Lakey JR, Robertson RP: Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51:3428-3434, 2000
5. Rickels MR, Schutta MH, Mueller R, Markmann JF, Barker CF, Naji A, Teff KL: Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes. Diabetes 54:3205-3211, 2005
6. Ansara MF, Saudek F, Newton M, Raynor AC, Cryer PE, Scharp DW: Pancreatic islet transplantation prevents defective glucose counter- regulation in diabetic dogs. Transplant Proc 26:664-665, 1994
7. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR: International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355:1318-1330, 2006
8. Vantyghem MC, Hazzan M, Tourvieille S, Provost F, Perimenis P, Declerck N, Sergent G, Kerr-Conte J, Noel C, Pattou F: Selection of diabetic patients for islet transplantation: a single-center experience. Diabete Metab 30:417-423, 2004
9. Andersson A, Korsgren O, Jansson L: Intraportally transplanted pancreatic islets revascularized from hepatic arterial system. Diabetes 38 (Suppl. 1):92-195, 1989
10. Lau J, Jansson L, Carlsson PO: Islets transplanted intraportally into the liver are stimulated to insulin and glucagon release exclusively through the hepatic artery. Am J Transplant 6:967-975, 2006
11. Shibata A, Ludvigsen CW Jr, Naber SP, McDaniel ML, Lacy PE: Standardization of a digestion-filtration method for isolation of pancreatic islets. Diabetes 25:667-672, 1976
12. Lo S, Russell JC, Taylor AW: Determination of glycogen in small tissue samples. J Appl Physiol 28:234-236, 1970
13. Hope KM, Tran PO, Zhou H, Oseid E, Leroy E, Robertson RP: Regulation of α-cell function by the β-Cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis. Diabetes 53:1488-1495, 2004
14. Zhou H, Tran PO, Yang S, Zhang T, LeRoy E, Oseid E, Robertson RP: Regulation of α-cell function by the β-Cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. Diabetes 53:1482-1487, 2004
15. Lau J, Mattsson G, Carlsson C, Nyqvist D, Kohler M, Berggren PO, Jansson L, Carlsson PO: Implantation site-dependent dysfunction of transplanted pancreatic islets. Diabetes 56:1544-1550, 2007
16. Gustavson SM, Rajotte RV, Hunkeler D, Lakey JRT, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cheerinton AD: Islet auto-islet transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha-cell response to mild non-insulin induced hypoglycemia. Am J Transplant 5:2368-2377, 2004